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    daxx death-domain associated protein [ Danio rerio (zebrafish) ]

    Gene ID: 561006, updated on 9-Dec-2024

    Summary

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    Official Symbol
    daxxprovided by ZNC
    Official Full Name
    death-domain associated proteinprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-010110-3
    See related
    Ensembl:ENSDARG00000000729 AllianceGenome:ZFIN:ZDB-GENE-010110-3
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    wu:fd15c03; si:dz179b20.7
    Summary
    Enables transcription corepressor activity. Acts upstream of or within negative regulation of DNA-templated transcription. Located in nucleus. Is expressed in several structures, including eye; gill; heart; liver; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in appendiceal neoplasm; islet cell tumor; oral squamous cell carcinoma; ovary epithelial cancer; and pancreatic endocrine carcinoma. Orthologous to human DAXX (death domain associated protein). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See daxx in Genome Data Viewer
    Location:
    chromosome: 19
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 19 NC_007130.7 (7014451..7033667, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 19 NC_007130.6 (7095790..7114740, complement)

    Chromosome 19 - NC_007130.7Genomic Context describing neighboring genes Neighboring gene kinesin family member C1 Neighboring gene zinc finger and BTB domain containing 22b Neighboring gene TAP binding protein (tapasin), tandem duplicate 1 Neighboring gene major histocompatibility complex class I UKA

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Molecular cloning and expression analysis of an apoptosis-associated gene Daxx from zebrafish, Danio rerio. Qi L, et al. Fish Shellfish Immunol, 2015 Jul. PMID 25862973
    2. Characterization of the MHC class I region of the Japanese pufferfish (Fugu rubripes). Clark MS, et al. Immunogenetics, 2001. PMID 11220619
    3. Structure, linkage mapping and expression of the heart-type fatty acid-binding protein gene (fabp3 ) from zebrafish (Danio rerio). Liu RZ, et al. Eur J Biochem, 2003 Aug. PMID 12869198
    4. Identification of seven genes in the major histocompatibility complex class I region of the zebrafish. Sültmann H, et al. Scand J Immunol, 2000 Jun. PMID 10849368
    5. A contig map of the Mhc class I genomic region in the zebrafish reveals ancient synteny. Michalová V, et al. J Immunol, 2000 May 15. PMID 10799891

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables histone binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transcription corepressor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within chromatin organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within negative regulation of DNA-templated transcription ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in PML body ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in chromosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in chromosome, centromeric region IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    death domain-associated protein 6
    Names
    death-associated protein 6
    fas-binding

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001044949.1 → NP_001038414.1  death domain-associated protein 6

      See identical proteins and their annotated locations for NP_001038414.1

      Status: PROVISIONAL

      Source sequence(s)
      BX927188
      UniProtKB/TrEMBL
      A0A8M2B6B4, Q1LUU4
      Related
      ENSDARP00000105452.1, ENSDART00000123443.3
      Conserved Domains (2) summary
      cd13150
      Location:195 → 400
      DAXX_histone_binding; Histone binding domain of the death-domain associated protein (DAXX)
      pfam03344
      Location:53 → 151
      Daxx; Daxx N-terminal Rassf1C-interacting domain

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007130.7 Reference GRCz11 Primary Assembly

      Range
      7014451..7033667 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017352251.3 → XP_017207740.1  death domain-associated protein 6 isoform X2

      UniProtKB/TrEMBL
      A0A8M6YWD7

    2. XM_005159438.5 → XP_005159495.2  death domain-associated protein 6 isoform X1

      UniProtKB/TrEMBL
      A0A8M2B6F2
      Conserved Domains (2) summary
      cd13150
      Location:242 → 447
      DAXX_histone_binding; Histone binding domain of the death-domain associated protein (DAXX)
      pfam03344
      Location:100 → 198
      Daxx; Daxx N-terminal Rassf1C-interacting domain

    3. XM_068215153.1 → XP_068071254.1  death domain-associated protein 6 isoform X4

      Related
      ENSDARP00000108588.2, ENSDART00000122815.4

    4. XM_005159440.5 → XP_005159497.1  death domain-associated protein 6 isoform X3

      See identical proteins and their annotated locations for XP_005159497.1

      UniProtKB/TrEMBL
      A0A8M2B6B4, Q1LUU4
      Conserved Domains (2) summary
      cd13150
      Location:195 → 400
      DAXX_histone_binding; Histone binding domain of the death-domain associated protein (DAXX)
      pfam03344
      Location:53 → 151
      Daxx; Daxx N-terminal Rassf1C-interacting domain
    Nucleotide Protein Strain
    Heading Accession and Version

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