smad7.L SMAD family member 7 L homeolog [Xenopus laevis (African clawed frog)] - Gene

Summary

Official Symbol: smad7.L
Official Full Name: SMAD family member 7 L homeolog
Primary source: Xenbase:XB-GENE-865569
Locus tag: XELAEV_18008457mg
See related: EnsemblRapid:ENSXLAG00005001500 AllianceGenome:Xenbase:XB-GENE-865569
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Xenopus laevis
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as: madh7; smad7; smad8; Smad10; xsmad7
Summary: Predicted to enable I-SMAD binding activity; metal ion binding activity; and transcription regulator inhibitor activity. Predicted to act upstream of or within several processes, including cell differentiation; cell surface receptor protein serine/threonine kinase signaling pathway; and regulation of transcription by RNA polymerase II. Predicted to be located in cytoplasm and nucleus. Predicted to be part of heteromeric SMAD protein complex. Is expressed in cardiovascular system; nervous system; and visual system. Human ortholog(s) of this gene implicated in colorectal cancer and pancreatic adenocarcinoma. Orthologous to human SMAD7 (SMAD family member 7). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

Location:: chromosome: 1L

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
101	current	Xenopus_laevis_v10.1 (GCF_017654675.1)	1L	NC_054371.1 (223297757..223322174, complement)
100	previous assembly	Xenopus_laevis_v2 (GCF_001663975.1)	1L	NC_030724.1 (210106248..210130876, complement)

Chromosome 1L - NC_054371.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The fibronectin type III (FN) domain and the intracellular domain of Tril are required to trigger Smad7 degradation in Xenopus embryos.
Title: Fibronectin type III and intracellular domains of Toll-like receptor 4 interactor with leucine-rich repeats (Tril) are required for developmental signaling.
Tril is a novel component of a Bmp-Gata2 positive-feedback loop that plays an essential role in hematopoietic specification, by targeting Smad7 for degradation.
Title: Tril targets Smad7 for degradation to allow hematopoietic specification in Xenopus embryos.
Smad7 has a role in Xenopus mesodermal and neural induction
Title: Unexpected activities of Smad7 in Xenopus mesodermal and neural induction.
cTid1 can bind to other members of the Smad family and that highest binding activity occurs with the negative regulatory Smad7, through the conserved MH2 domain
Title: Tid1 is a Smad-binding protein that can modulate Smad7 activity in developing embryos.

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General gene information

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Gene Ontology Provided by Xenbase

Function	Evidence Code	Pubs
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
part_of transcription regulator complex	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: SMAD family member 7 L homeolog

Names: MAD, mothers against decapentaplegic homolog 7

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001087548.1 → NP_001081017.1 SMAD family member 7 L homeolog

See identical proteins and their annotated locations for NP_001081017.1

Status: PROVISIONAL

Source sequence(s)

BC059286

UniProtKB/TrEMBL

A0A974E3I1, O57459, O57522

Related

ENSXLAP00005004588.1, ENSXLAT00005004654.1

Conserved Domains (2) summary

cd10494
Location:36 → 163

MH1_SMAD_7; N-terminal Mad Homology 1 (MH1) domain in SMAD7

cd10500
Location:210 → 380

MH2_SMAD_7; C-terminal Mad Homology 2 (MH2) domain in SMAD7

RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Xenopus_laevis_v10.1 Primary Assembly

Genomic

NC_054371.1 Reference Xenopus_laevis_v10.1 Primary Assembly

Range

223297757..223322174 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)