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    cep128 centrosomal protein 128 [ Danio rerio (zebrafish) ]

    Gene ID: 100037385, updated on 9-Dec-2024

    Summary

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    Official Symbol
    cep128provided by ZNC
    Official Full Name
    centrosomal protein 128provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-070410-34
    See related
    Ensembl:ENSDARG00000103771 AllianceGenome:ZFIN:ZDB-GENE-070410-34
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    zgc:162199
    Summary
    Acts upstream of or within heart development; liver development; and pancreas development. Orthologous to human CEP128 (centrosomal protein 128). [provided by Alliance of Genome Resources, Dec 2024]
    Annotation information
    Annotation category: partial on reference assembly
    Orthologs
    all
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    Genomic context

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    See cep128 in Genome Data Viewer
    Location:
    chromosome: 20
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 20 NC_007131.7 (5985637..6037014)
    105 previous assembly GRCz10 (GCF_000002035.5) 20 NC_007131.6 (5941369..5995115)

    Chromosome 20 - NC_007131.7Genomic Context describing neighboring genes Neighboring gene SNW domain containing 1 Neighboring gene neurexin 3b Neighboring gene uncharacterized LOC137488611 Neighboring gene centrosomal protein of 128 kDa Neighboring gene thyroid stimulating hormone receptor Neighboring gene pumilio RNA-binding family member 2 Neighboring gene transthyretin (prealbumin, amyloidosis type I)

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. CEP128 Localizes to the Subdistal Appendages of the Mother Centriole and Regulates TGF-β/BMP Signaling at the Primary Cilium. Mönnich M, et al. Cell Rep, 2018 Mar 6. PMID 29514088
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article
    4. Gene evolution and gene expression after whole genome duplication in fish: the PhyloFish database. Pasquier J, et al. BMC Genomics, 2016 May 18. PMID 27189481, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. CEP128 loss affects TGF-beta1-induced phosphorylation of multiple proteins that regulate cilium-associated vesicle trafficking.
      Title: CEP128 Localizes to the Subdistal Appendages of the Mother Centriole and Regulates TGF-β/BMP Signaling at the Primary Cilium.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within heart development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within liver development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within pancreas development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  
    is_active_in centriole IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in spindle pole IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    centrosomal protein of 128 kDa

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001089536.1 → NP_001083005.1  centrosomal protein of 128 kDa

      See identical proteins and their annotated locations for NP_001083005.1

      Status: PROVISIONAL

      Source sequence(s)
      BC139544
      UniProtKB/TrEMBL
      A4QNW2
      Related
      ENSDARP00000135795.2, ENSDART00000165489.2
      Conserved Domains (2) summary
      TIGR02168
      Location:422 → 710
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      TIGR02169
      Location:633 → 910
      SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007131.7 Reference GRCz11 Primary Assembly

      Range
      5985637..6037014
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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