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    aspn asporin (LRR class 1) [ Danio rerio (zebrafish) ]

    Gene ID: 65228, updated on 9-Dec-2024

    Summary

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    Official Symbol
    aspnprovided by ZNC
    Official Full Name
    asporin (LRR class 1)provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-041105-7
    See related
    Ensembl:ENSDARG00000002192 AllianceGenome:ZFIN:ZDB-GENE-041105-7
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    bgl3; aspnl; wu:fk08c11; zgc:109936
    Summary
    Predicted to be located in extracellular region. Predicted to be active in extracellular space. Is expressed in axial vasculature; chondrocranium; and pharyngeal arch. Human ortholog(s) of this gene implicated in ankylosing spondylitis; degenerative disc disease; and osteoarthritis. Orthologous to human ASPN (asporin). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See aspn in Genome Data Viewer
    Location:
    chromosome: 22
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 22 NC_007133.7 (10479965..10487511, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 22 NC_007133.6 (10450283..10457829, complement)

    Chromosome 22 - NC_007133.7Genomic Context describing neighboring genes Neighboring gene centromere protein P Neighboring gene osteoglycin, paralog a Neighboring gene osteomodulin Neighboring gene extracellular matrix protein 2, female organ and adipocyte specific Neighboring gene inositol 1,3,4,5,6-pentakisphosphate 2-kinase

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Biglycan-like extracellular matrix genes of agnathans and teleosts. Shintani S, et al. J Mol Evol, 2000 Oct. PMID 11040287
    2. Toxicity responses of different organs of zebrafish (Danio rerio) to silver nanoparticles with different particle sizes and surface coatings. Liu H, et al. Environ Pollut, 2019 Mar. PMID 30579210
    3. A switch in pdgfrb(+) cell-derived ECM composition prevents inhibitory scarring and promotes axon regeneration in the zebrafish spinal cord. Tsata V, et al. Dev Cell, 2021 Feb 22. PMID 33412105
    4. Screen for genes differentially expressed during regeneration of the zebrafish caudal fin. Padhi BK, et al. Dev Dyn, 2004 Nov. PMID 15376328
    5. Embryonic temperature affects muscle fibre recruitment in adult zebrafish: genome-wide changes in gene and microRNA expression associated with the transition from hyperplastic to hypertrophic growth phenotypes. Johnston IA, et al. J Exp Biol, 2009 Jun. PMID 19482995

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Component Evidence Code Pubs
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    asporin
    Names
    biglycan-like protein 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_131713.2 → NP_571788.2  asporin precursor

      Status: VALIDATED

      Source sequence(s)
      BC078368, EE689153, EE697401
      UniProtKB/TrEMBL
      A0A8M1P6K1, Q1LXA7
      Related
      ENSDARP00000064797.5, ENSDART00000064798.6
      Conserved Domains (4) summary
      smart00013
      Location:64 → 94
      LRRNT; Leucine rich repeat N-terminal domain
      cd00116
      Location:133 → 323
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00033
      Location:74 → 93
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:97 → 152
      LRR_8; Leucine rich repeat

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007133.7 Reference GRCz11 Primary Assembly

      Range
      10479965..10487511 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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