paics.L phosphoribosylaminoimidazole carboxylase and phosphoribosylaminoimidazolesuccinocarboxamide synthase L homeolog [Xenopus laevis (African clawed frog)] - Gene

Summary

Official Symbol: paics.L
Official Full Name: phosphoribosylaminoimidazole carboxylase and phosphoribosylaminoimidazolesuccinocarboxamide synthase L homeolog
Primary source: Xenbase:XB-GENE-17334793
See related: EnsemblRapid:ENSXLAG00005006406 AllianceGenome:Xenbase:XB-GENE-17334793
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Xenopus laevis
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as: ade2; airc; pais; paics; paics.1; paics.1.L
Summary: Predicted to enable ATP binding activity; phosphoribosylaminoimidazole carboxylase activity; and phosphoribosylaminoimidazolesuccinocarboxamide synthase activity. Predicted to act upstream of or within 'de novo' IMP biosynthetic process. Human ortholog(s) of this gene implicated in schizophrenia. Orthologous to human PAICS (phosphoribosylaminoimidazole carboxylase and phosphoribosylaminoimidazolesuccinocarboxamide synthase). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

Location:: chromosome: 1L

Exon count:: 17

Annotation release	Status	Assembly	Chr	Location
101	current	Xenopus_laevis_v10.1 (GCF_017654675.1)	1L	NC_054371.1 (42649796..42676953)
100	previous assembly	Xenopus_laevis_v2 (GCF_001663975.1)	1L	NC_030724.1 (33422589..33432609)

Chromosome 1L - NC_054371.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by Xenbase

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables carboxy-lyase activity	IEA Inferred from Electronic Annotation more info
enables ligase activity	IEA Inferred from Electronic Annotation more info
enables phosphoribosylaminoimidazole carboxylase activity	IEA Inferred from Electronic Annotation more info
enables phosphoribosylaminoimidazolesuccinocarboxamide synthase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within 'de novo' IMP biosynthetic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within purine nucleotide biosynthetic process	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: multifunctional protein ADE2-like

Names: phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoribosylaminoimidazole succinocarboxamide synthetase; phosphoribosylaminoimidazole carboxylase; phosphoribosylaminoimidazolesuccinocarboxamide synthase L homeolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001086694.1 → NP_001080163.1 multifunctional protein ADE2-like

See identical proteins and their annotated locations for NP_001080163.1

Status: PROVISIONAL

Source sequence(s)

BC041276

UniProtKB/TrEMBL

Q8AVT1

Related

ENSXLAP00005019124.1, ENSXLAT00005019459.1

Conserved Domains (2) summary

cd01416
Location:7 → 258

SAICAR_synt_Ade5; Ade5_like 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase

TIGR01162
Location:268 → 421

purE; phosphoribosylaminoimidazole carboxylase, PurE protein

RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Xenopus_laevis_v10.1 Primary Assembly

Genomic

NC_054371.1 Reference Xenopus_laevis_v10.1 Primary Assembly

Range

42649796..42676953

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_041562014.1 → XP_041417948.1 multifunctional protein ADE2-like isoform X1

UniProtKB/TrEMBL

A0A1L8HTT3, A0A974DX35

Conserved Domains (3) summary

cd01416
Location:565 → 816

SAICAR_synt_Ade5; Ade5_like 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase

TIGR01162
Location:826 → 979

purE; phosphoribosylaminoimidazole carboxylase, PurE protein

pfam13837
Location:6 → 90

Myb_DNA-bind_4; Myb/SANT-like DNA-binding domain
XM_041562028.1 → XP_041417962.1 multifunctional protein ADE2-like isoform X2

UniProtKB/TrEMBL

A0A8J1KKW5

Conserved Domains (3) summary

cd01416
Location:564 → 815

SAICAR_synt_Ade5; Ade5_like 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase

TIGR01162
Location:825 → 978

purE; phosphoribosylaminoimidazole carboxylase, PurE protein

cl23759
Location:9 → 74

GT1; myb-like, SANT family
XM_018266896.2 → XP_018122385.1 multifunctional protein ADE2-like isoform X3

UniProtKB/TrEMBL

A0A8J0VJA3