mars1.S methionyl-tRNA synthetase 1 S homeolog [Xenopus laevis (African clawed frog)] - Gene

Summary

Official Symbol: mars1.S
Official Full Name: methionyl-tRNA synthetase 1 S homeolog
Primary source: Xenbase:XB-GENE-17340220
Locus tag: XELAEV_18015931mg
See related: EnsemblRapid:ENSXLAG00005033209 AllianceGenome:Xenbase:XB-GENE-17340220
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Xenopus laevis
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as: mars; mars1; mtrns
Summary: Predicted to enable methionine-tRNA ligase activity. Predicted to act upstream of or within methionyl-tRNA aminoacylation. Predicted to be located in cytosol and nucleolus. Predicted to be part of aminoacyl-tRNA synthetase multienzyme complex. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease axonal type 2U; hereditary spastic paraplegia 70; and trichothiodystrophy. Orthologous to human MARS1 (methionyl-tRNA synthetase 1). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

Location:: chromosome: 2S

Exon count:: 22

Annotation release	Status	Assembly	Chr	Location
101	current	Xenopus_laevis_v10.1 (GCF_017654675.1)	2S	NC_054374.1 (132259079..132286718)
100	previous assembly	Xenopus_laevis_v2 (GCF_001663975.1)	2S	NC_030727.1 (123245810..123273325)

Chromosome 2S - NC_054374.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by Xenbase

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables aminoacyl-tRNA ligase activity	IEA Inferred from Electronic Annotation more info
enables catalytic activity	IEA Inferred from Electronic Annotation more info
enables methionine-tRNA ligase activity	IEA Inferred from Electronic Annotation more info
enables methionine-tRNA ligase activity	ISS Inferred from Sequence or Structural Similarity more info
enables tRNA binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within methionyl-tRNA aminoacylation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within methionyl-tRNA aminoacylation	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within tRNA aminoacylation for protein translation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within translation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of aminoacyl-tRNA synthetase multienzyme complex	IEA Inferred from Electronic Annotation more info
part_of aminoacyl-tRNA synthetase multienzyme complex	ISS Inferred from Sequence or Structural Similarity more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in nucleolus	IEA Inferred from Electronic Annotation more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: methionine--tRNA ligase, cytoplasmic

Names: metRS; methionyl-tRNA synthetase, cytoplasmic

NP_001079984.1

EC 6.1.1.10

XP_041438913.1

EC 6.1.1.10

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001086515.1 → NP_001079984.1 methionine--tRNA ligase, cytoplasmic

See identical proteins and their annotated locations for NP_001079984.1

Status: PROVISIONAL

Source sequence(s)

BC057757

UniProtKB/Swiss-Prot

Q6PF21

UniProtKB/TrEMBL

A0A974DKK1

Related

ENSXLAP00005099544.1, ENSXLAT00005101452.1

Conserved Domains (7) summary

cd07957
Location:640 → 769

Anticodon_Ia_Met; Anticodon-binding domain of methionyl tRNA synthetases

cd00814
Location:263 → 631

MetRS_core; catalytic core domain of methioninyl-tRNA synthetases

cd10307
Location:75 → 177

GST_C_MetRS_N; Glutathione S-transferase C-terminal-like, alpha helical domain of Methionyl-tRNA synthetase from higher eukaryotes

COG0625
Location:1 → 177

GstA; Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]

PRK12268
Location:262 → 816

PRK12268; methionyl-tRNA synthetase; Reviewed

cd00939
Location:848 → 877

MetRS_RNA; MetRS_RNA binding domain. This short RNA-binding domain is found at the C-terminus of MetRS in several higher eukaryote aminoacyl-tRNA synthetases (aaRSs). It is repeated in Drosophila MetRS. This domain consists of a helix-turn-helix structure, which is ...

cl00388
Location:2 → 67

Thioredoxin_like; Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold

RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Xenopus_laevis_v10.1 Primary Assembly

Genomic

NC_054374.1 Reference Xenopus_laevis_v10.1 Primary Assembly

Range

132259079..132286718

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_041582979.1 → XP_041438913.1 methionine--tRNA ligase, cytoplasmic isoform X1

UniProtKB/TrEMBL

A0A8J1MBE2, A0A974DKK1

Related

ENSXLAP00005099357.1, ENSXLAT00005101242.1

Conserved Domains (4) summary

cd10307
Location:75 → 177

GST_C_MetRS_N; Glutathione S-transferase C-terminal-like, alpha helical domain of Methionyl-tRNA synthetase from higher eukaryotes

smart00991
Location:859 → 913

WHEP-TRS; A conserved domain of 46 amino acids, called WHEP-TRS has been shown.to exist in a number of higher eukaryote aminoacyl-transfer RNA synthetases

PLN02610
Location:251 → 882

PLN02610; probable methionyl-tRNA synthetase

cl00388
Location:2 → 67

Thioredoxin_like; Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold