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    Anxa9 annexin A9 [ Mus musculus (house mouse) ]

    Gene ID: 71790, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Anxa9provided by MGI
    Official Full Name
    annexin A9provided by MGI
    Primary source
    MGI:MGI:1923711
    See related
    Ensembl:ENSMUSG00000015702 AllianceGenome:MGI:1923711
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    1110003P15Rik; 2310069F17Rik
    Summary
    Predicted to enable acetylcholine receptor activity; calcium-dependent phospholipid binding activity; and phosphatidylserine binding activity. Predicted to be involved in cell-cell adhesion. Located in collagen-containing extracellular matrix. Is expressed in several structures, including ganglia; trigeminal nerve; urinary system; vertebral axis musculature; and vibrissa. Orthologous to human ANXA9 (annexin A9). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in genital fat pad adult (RPKM 7.5), stomach adult (RPKM 4.5) and 26 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Anxa9 in Genome Data Viewer
    Location:
    3 F2.1; 3 40.74 cM
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (95203404..95222491, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (95296093..95315180, complement)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene predicted gene 128 Neighboring gene BCL2/adenovirus E1B 19kD interacting protein like Neighboring gene prune exopolyphosphatase Neighboring gene STARR-positive B cell enhancer ABC_E2672 Neighboring gene MINDY lysine 48 deubiquitinase 1 Neighboring gene STARR-positive B cell enhancer ABC_E9560 Neighboring gene predicted gene, 53243 Neighboring gene ceramide synthase 2 Neighboring gene SET domain, bifurcated 1 Neighboring gene STARR-seq mESC enhancer starr_08380 Neighboring gene STARR-positive B cell enhancer mm9_chr3:95161130-95161430 Neighboring gene predicted gene, 37500 Neighboring gene cortexin domain containing 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Structural and functional characterisation of the mouse annexin A9 promoter. Chlystun M, et al. Biochim Biophys Acta, 2004 Dec 6. PMID 15590064
    2. Annexin A9 is a periplakin interacting partner in membrane-targeted cytoskeletal linker protein complexes. Boczonadi V, et al. FEBS Lett, 2012 Sep 21. PMID 22841549
    3. The matrisome: in silico definition and in vivo characterization by proteomics of normal and tumor extracellular matrices. Naba A, et al. Mol Cell Proteomics, 2012 Apr. PMID 22159717, Free PMC Article
    4. Targeting a complex transcriptome: the construction of the mouse full-length cDNA encyclopedia. Carninci P, et al. Genome Res, 2003 Jun. PMID 12819125, Free PMC Article
    5. Mouse screen reveals multiple new genes underlying mouse and human hearing loss. Ingham NJ, et al. PLoS Biol, 2019 Apr. PMID 30973865, Free PMC Article

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (2) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables acetylcholine receptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables acetylcholine receptor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables calcium-dependent phospholipid binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables calcium-dependent phospholipid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphatidylserine binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phosphatidylserine binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables phosphatidylserine binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables phospholipid binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables phospholipid binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell-cell adhesion ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cell-cell adhesion ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in synaptic transmission, cholinergic IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cell surface ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cell surface ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in collagen-containing extracellular matrix HDA PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in synapse IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in vesicle membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    annexin A9
    Names
    annexin XXXI
    annexin-31
    annexin-9

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001085383.1 → NP_001078852.1  annexin A9 isoform a

      See identical proteins and their annotated locations for NP_001078852.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1), as well as variants 2 and 3, encodes the longer isoform (a).
      Source sequence(s)
      BC062140, BY781208
      Consensus CDS
      CCDS50989.1
      UniProtKB/Swiss-Prot
      Q9CQS1, Q9JHQ0
      Related
      ENSMUSP00000102801.2, ENSMUST00000107183.8
      Conserved Domains (2) summary
      pfam00191
      Location:46 → 110
      Annexin
      cl02574
      Location:222 → 264
      Annexin

    2. NM_001379545.1 → NP_001366474.1  annexin A9 isoform a

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) represents the longest transcript and encodes the longer isoform (a). Variants 1-3 all encode the same isoform (a).
      Source sequence(s)
      AC140190
      UniProtKB/Swiss-Prot
      Q9CQS1, Q9JHQ0
      Conserved Domains (2) summary
      pfam00191
      Location:46 → 110
      Annexin
      cl02574
      Location:222 → 264
      Annexin

    3. NM_001379546.1 → NP_001366475.1  annexin A9 isoform b

      Status: VALIDATED

      Source sequence(s)
      AC140190
      Conserved Domains (2) summary
      pfam00191
      Location:236 → 301
      Annexin
      cl02574
      Location:184 → 226
      Annexin

    4. NM_023628.3 → NP_076117.2  annexin A9 isoform a

      See identical proteins and their annotated locations for NP_076117.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2), as well as variants 1 and 3, encodes the longer isoform (a).
      Source sequence(s)
      AC140190
      Consensus CDS
      CCDS50989.1
      UniProtKB/Swiss-Prot
      Q9CQS1, Q9JHQ0
      Related
      ENSMUSP00000015846.3, ENSMUST00000015846.9
      Conserved Domains (2) summary
      pfam00191
      Location:46 → 110
      Annexin
      cl02574
      Location:222 → 264
      Annexin

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      95203404..95222491 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036163335.1 → XP_036019228.1  annexin A9 isoform X1

      Conserved Domains (2) summary
      pfam00191
      Location:236 → 301
      Annexin
      cl02574
      Location:184 → 226
      Annexin

    RNA

    1. XR_375584.4 RNA Sequence

    2. XR_004941397.1 RNA Sequence

    3. XR_004941398.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9JHQ0.2 GenPept UniProtKB/Swiss-Prot:Q9JHQ0

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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