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    CBP20 CAP-binding protein 20 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 834443, updated on 18-Sep-2024

    Summary

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    Official Symbol
    CBP20
    Official Full Name
    CAP-binding protein 20
    Primary source
    TAIR:AT5G44200
    Locus tag
    AT5G44200
    See related
    Araport:AT5G44200
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ATCBP20; CAP-binding protein 20; MLN1.12; MLN1_12
    Summary
    Encodes a nuclear cap-binding protein that forms a heterodimeric complex with ABH1 (ATCBP80) and is likely to participate in RNA metabolism. Its mRNA is ubiquitously expressed.Loss of function mutations suggest a role in processing of pri-miRNA and mRNA splicing.
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    Genomic context

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    See CBP20 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    9
    Sequence:
    Chromosome: 5; NC_003076.8 (17801737..17804203, complement)

    Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene Homeodomain-like transcriptional regulator Neighboring gene GOLDEN2-like 2 Neighboring gene erf domain protein 9 Neighboring gene F-box family protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003076.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. New phenotypes of the drought-tolerant cbp20 Arabidopsis thaliana mutant have changed epidermal morphology. Jäger K, et al. Plant Biol (Stuttg), 2011 Jan. PMID 21143728
    2. Cloning and characterization of two subunits of Arabidopsis thaliana nuclear cap-binding complex. Kmieciak M, et al. Gene, 2002 Jan 23. PMID 11867224
    3. Quantitative proteomics analysis reveals that the nuclear cap-binding complex proteins arabidopsis CBP20 and CBP80 modulate the salt stress response. Kong X, et al. J Proteome Res, 2014 May 2. PMID 24689873
    4. Involvement of the nuclear cap-binding protein complex in alternative splicing in Arabidopsis thaliana. Raczynska KD, et al. Nucleic Acids Res, 2010 Jan. PMID 19864257, Free PMC Article
    5. Selective recruitment of proteins to 5' cap complexes during the growth cycle in Arabidopsis. Bush MS, et al. Plant J, 2009 Aug. PMID 19453450

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. we proposed that ethylene regulated phosphorylation of CBP20 is involved in the root growth and one pathway is through the regulation of miR319b and its target MYB33 in roots
      Title: Phosphorylation of CBP20 Links MicroRNA to Root Growth in the Ethylene Response.
    2. Data suggest that CBP20 and CBP80 (ABH1) have synergistic roles during the salt stress response.
      Title: Quantitative proteomics analysis reveals that the nuclear cap-binding complex proteins arabidopsis CBP20 and CBP80 modulate the salt stress response.
    3. SERRATE, CAP BINDING PROTEIN20 (CBP20), and CBP80 are regulators of lincRNA expression and biogenesis. RT-PCR experiments confirmed these three proteins are also needed for splicing of a small group of intron-containing lincRNAs.
      Title: Genome-wide analysis uncovers regulation of long intergenic noncoding RNAs in Arabidopsis.
    4. Some hitherto undescribed changes were found in the tissue structure and epidermal morphology of cbp20 mutant
      Title: New phenotypes of the drought-tolerant cbp20 Arabidopsis thaliana mutant have changed epidermal morphology.
    5. The cbp80(abh1) and cbp20/80 mutants had many more changes in alternative splicing in common than did cbp20 and cbp20/80 suggesting that CBP80 plays a more significant role in alternative splicing than CBP20.
      Title: Involvement of the nuclear cap-binding protein complex in alternative splicing in Arabidopsis thaliana.
    6. The N-terminal part of AtCBP20 is crucial for the formation of a complex with AtCBP80.
      Title: The Arabidopsis CBP20 targets the cap-binding complex to the nucleus, and is stabilized by CBP80.
    7. CBP20 and CBP80 function in miRNA biogenesis by binding to pri-miRNA transcripts, and are stabilized by ABA by a post-translational mechanism.
      Title: Two cap-binding proteins CBP20 and CBP80 are involved in processing primary MicroRNAs.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_001085236.2
    NM_123787.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables RNA cap binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within RNA metabolic process TAS
    Traceable Author Statement
    more info
    		 PubMed 
    acts_upstream_of_or_within RNA splicing, via endonucleolytic cleavage and ligation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within defense response to virus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mRNA cis splicing, via spliceosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within primary miRNA processing IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    CAP-binding protein 20
    NP_001078705.1
    • CAP-binding protein 20 (CBP20); FUNCTIONS IN: RNA binding, RNA cap binding; INVOLVED IN: RNA metabolic process, RNA splicing, via endonucleolytic cleavage and ligation, primary microRNA processing; LOCATED IN: mRNA cap binding complex; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: RNA recognition motif, RNP-1 (InterPro:IPR000504), Nucleotide-binding, alpha-beta plait (InterPro:IPR012677); BEST Arabidopsis thaliana protein match is: RNA-binding (RRM/RBD/RNP motifs) family protein (TAIR:AT3G46020.1); Has 9575 Blast hits to 9549 proteins in 2190 species: Archae - 96; Bacteria - 7682; Metazoa - 239; Fungi - 361; Plants - 280; Viruses - 2; Other Eukaryotes - 915 (source: NCBI BLink).
    NP_199233.1
    • CAP-binding protein 20 (CBP20); FUNCTIONS IN: RNA binding, RNA cap binding; INVOLVED IN: RNA metabolic process, RNA splicing, via endonucleolytic cleavage and ligation, primary microRNA processing; LOCATED IN: mRNA cap binding complex; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: RNA recognition motif, RNP-1 (InterPro:IPR000504), Nucleotide-binding, alpha-beta plait (InterPro:IPR012677); BEST Arabidopsis thaliana protein match is: RNA-binding (RRM/RBD/RNP motifs) family protein (TAIR:AT3G46020.1); Has 1672 Blast hits to 1670 proteins in 70 species: Archae - 0; Bacteria - 6; Metazoa - 7; Fungi - 2; Plants - 1623; Viruses - 0; Other Eukaryotes - 34 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003076.8 Reference assembly

      Range
      17801737..17804203 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001085236.2 → NP_001078705.1  CAP-binding protein 20 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001078705.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9XFD1
      UniProtKB/TrEMBL
      A0A178UGA0
      Conserved Domains (2) summary
      COG0724
      Location:33 → 118
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      cd12240
      Location:36 → 113
      RRM_NCBP2; RNA recognition motif found in nuclear cap-binding protein subunit 2 (CBP20) and similar proteins

    2. NM_123787.4 → NP_199233.1  CAP-binding protein 20 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_199233.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9XFD1
      UniProtKB/TrEMBL
      A0A178UGA0
      Conserved Domains (2) summary
      COG0724
      Location:33 → 118
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      cd12240
      Location:36 → 113
      RRM_NCBP2; RNA recognition motif found in nuclear cap-binding protein subunit 2 (CBP20) and similar proteins
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9XFD1.1

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