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    AXL AXL receptor tyrosine kinase [ Theropithecus gelada (gelada) ]

    Gene ID: 112612153, updated on 11-Apr-2024

    Summary

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    Gene symbol
    AXL
    Gene description
    AXL receptor tyrosine kinase
    See related
    Ensembl:ENSTGEG00000022986
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Theropithecus gelada
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Theropithecus
    Orthologs
    human mouse all
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    Genomic context

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    See AXL in Genome Data Viewer
    Location:
    chromosome: 19
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    100 current Tgel_1.0 (GCF_003255815.1) 19 NC_037687.1 (38776485..38821936, complement)

    Chromosome 19 - NC_037687.1Genomic Context describing neighboring genes Neighboring gene coiled-coil domain containing 97 Neighboring gene heterogeneous nuclear ribonucleoprotein U like 1 Neighboring gene transfer RNA lysine (anticodon UUU) Neighboring gene cytochrome P450 2S1 Neighboring gene cytochrome P450 2A13-like Neighboring gene cytochrome P450 2F5-like

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037687.1 Chromosome 19 Reference Tgel_1.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables protein binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables transmembrane receptor protein tyrosine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cell migration IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in cell surface receptor protein tyrosine kinase signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in multicellular organism development IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in natural killer cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in negative regulation of apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in nervous system development IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in phagocytosis IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in platelet activation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of receptor complex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    tyrosine-protein kinase receptor UFO

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Theropithecus gelada Annotation Release 100 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Tgel_1.0 Primary Assembly

    Genomic

    1. NC_037687.1 Reference Tgel_1.0 Primary Assembly

      Range
      38776485..38821936 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_025366287.1 → XP_025222072.1  tyrosine-protein kinase receptor UFO isoform X1

      Conserved Domains (5) summary
      cd05749
      Location:141 → 222
      Ig2_Axl_Tyro3_like; Second immunoglobulin (Ig)-like domain of Axl/Tyro3 family receptor tyrosine kinases (RTKs)
      cd00063
      Location:225 → 328
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd05075
      Location:552 → 828
      PTKc_Axl; Catalytic domain of the Protein Tyrosine Kinase, Axl
      pfam00041
      Location:335 → 418
      fn3; Fibronectin type III domain
      cd00096
      Location:53 → 119
      Ig; Immunoglobulin domain

    2. XM_025366289.1 → XP_025222074.1  tyrosine-protein kinase receptor UFO isoform X3

      UniProtKB/TrEMBL
      A0A8D2K748
      Related
      ENSTGEP00000028557.1, ENSTGET00000034032.1
      Conserved Domains (5) summary
      cd05749
      Location:141 → 222
      Ig2_Axl_Tyro3_like; Second immunoglobulin (Ig)-like domain of Axl/Tyro3 family receptor tyrosine kinases (RTKs)
      cd00063
      Location:225 → 328
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd05075
      Location:526 → 802
      PTKc_Axl; Catalytic domain of the Protein Tyrosine Kinase, Axl
      pfam00041
      Location:335 → 418
      fn3; Fibronectin type III domain
      cd00096
      Location:53 → 119
      Ig; Immunoglobulin domain

    3. XM_025366288.1 → XP_025222073.1  tyrosine-protein kinase receptor UFO isoform X2

      UniProtKB/TrEMBL
      A0A8D2G1D2
      Related
      ENSTGEP00000028549.1, ENSTGET00000034023.1
      Conserved Domains (5) summary
      cd05749
      Location:141 → 222
      Ig2_Axl_Tyro3_like; Second immunoglobulin (Ig)-like domain of Axl/Tyro3 family receptor tyrosine kinases (RTKs)
      cd00063
      Location:225 → 328
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd05075
      Location:535 → 811
      PTKc_Axl; Catalytic domain of the Protein Tyrosine Kinase, Axl
      pfam00041
      Location:335 → 418
      fn3; Fibronectin type III domain
      cd00096
      Location:53 → 119
      Ig; Immunoglobulin domain

    4. XM_025366290.1 → XP_025222075.1  tyrosine-protein kinase receptor UFO isoform X4

      Conserved Domains (3) summary
      cd00063
      Location:26 → 66
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd05075
      Location:273 → 549
      PTKc_Axl; Catalytic domain of the Protein Tyrosine Kinase, Axl
      pfam00041
      Location:73 → 156
      fn3; Fibronectin type III domain
    Nucleotide Protein
    Heading Accession and Version

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