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    Vpreb1b V-set pre-B cell surrogate light chain 1B [ Mus musculus (house mouse) ]

    Gene ID: 22363, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Vpreb1bprovided by MGI
    Official Full Name
    V-set pre-B cell surrogate light chain 1Bprovided by MGI
    Primary source
    MGI:MGI:98937
    See related
    Ensembl:ENSMUSG00000059280 AllianceGenome:MGI:98937
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    CD179b; VpreB1; Vpreb2; Vpreb-2
    Summary
    Acts upstream of or within several processes, including B cell homeostasis; B cell proliferation; and regulation of cell size. Predicted to be part of immunoglobulin complex. Is expressed in bone marrow; liver; and spleen. Orthologous to human VPREB1 (V-set pre-B cell surrogate light chain 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in liver E18 (RPKM 2.4), thymus adult (RPKM 0.3) and 4 other tissues See more
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    Genomic context

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    See Vpreb1b in Genome Data Viewer
    Location:
    16 A3; 16 11.14 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (17797314..17799138)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (17979445..17981274)

    Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_40267 Neighboring gene solute carrier family 25 (mitochondrial carrier, citrate transporter), member 1 Neighboring gene predicted gene, 41427 Neighboring gene STARR-seq mESC enhancer starr_40270 Neighboring gene STARR-seq mESC enhancer starr_40272 Neighboring gene STARR-seq mESC enhancer starr_40274 Neighboring gene predicted gene, 49580 Neighboring gene DiGeorge syndrome critical region gene 6

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Interaction of murine precursor B cell receptor with stroma cells is controlled by the unique tail of lambda 5 and stroma cell-associated heparan sulfate. Bradl H, et al. J Immunol, 2003 Sep 1. PMID 12928380
    2. Restriction fragment analysis of V preB and lambda 5 within the genus Mus. D'Hoostelaere LA, et al. Eur J Immunol, 1989 Jan. PMID 2563973
    3. Loss of precursor B cell expansion but not allelic exclusion in VpreB1/VpreB2 double-deficient mice. Mundt C, et al. J Exp Med, 2001 Feb 19. PMID 11181696, Free PMC Article
    4. The pre-B-cell receptor induces silencing of VpreB and lambda5 transcription. Parker MJ, et al. EMBO J, 2005 Nov 16. PMID 16281060, Free PMC Article
    5. Only VpreB1, but not VpreB2, is expressed at levels which allow normal development of B cells. Mundt C, et al. Int Immunol, 2006 Jan. PMID 16361315

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Data show no autoantibody production was detectable in surrogate light chain (SLC) components VpreB/CD179a and lambda5/CD179b transgenic mice.
      Title: Surrogate light chain expression beyond the pre-B cell stage promotes tolerance in a dose-dependent fashion.
    2. VpreB probes the fitness of newly generated VH domains of IgH chains for later pairing with IgL chains, and its non-Ig part fixes the preBCRs on the surface.
      Title: The non-Ig parts of the VpreB and λ5 proteins of the surrogate light chain play opposite roles in the surface representation of the precursor B cell receptor.
    3. Data demonstrate that the pre-B-cell receptor is essential for monoallelic silencing of VpreB and lambda5 at the large pre-BII-cell stage.
      Title: The pre-B-cell receptor induces silencing of VpreB and lambda5 transcription.
    4. Efficient binding of a soluble murine pre-B cell receptor to stroma cells requires the non-immunoglobulin-like unique tail of lambda 5.
      Title: Interaction of murine precursor B cell receptor with stroma cells is controlled by the unique tail of lambda 5 and stroma cell-associated heparan sulfate.
    5. Mice triply deficient for VpreB2 show B cell developmental defects but functional allelic exclusion of the IgH locus.
      Title: VpreB1/VpreB2/lambda 5 triple-deficient mice show impaired B cell development but functional allelic exclusion of the IgH locus.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (3)  1 citation

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    acts_upstream_of_or_within B cell homeostasis IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within B cell proliferation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within cell morphogenesis IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within regulation of cell size IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of immunoglobulin complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    immunoglobulin omega chain
    Names
    Lambda 5
    pre-B lymphocyte gene 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_016983.1 → NP_058679.1  immunoglobulin omega chain precursor

      See identical proteins and their annotated locations for NP_058679.1

      Status: VALIDATED

      Source sequence(s)
      X05563
      Consensus CDS
      CCDS28015.1
      UniProtKB/Swiss-Prot
      P13373
      UniProtKB/TrEMBL
      Q0VEN0
      Related
      ENSMUSP00000074835.4, ENSMUST00000075371.5
      Conserved Domains (2) summary
      smart00410
      Location:26 → 125
      IG_like; Immunoglobulin like
      cl11960
      Location:29 → 118
      Ig; Immunoglobulin domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000082.7 Reference GRCm39 C57BL/6J

      Range
      17797314..17799138
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017316944.3 → XP_017172433.1  immunoglobulin omega chain isoform X1

      UniProtKB/TrEMBL
      Q0VEN0
      Conserved Domains (1) summary
      cl11960
      Location:58 → 147
      Ig; Immunoglobulin domain

    2. XM_017316945.2 → XP_017172434.1  immunoglobulin omega chain isoform X1

      UniProtKB/TrEMBL
      Q0VEN0
      Conserved Domains (1) summary
      cl11960
      Location:58 → 147
      Ig; Immunoglobulin domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P13373.1 GenPept UniProtKB/Swiss-Prot:P13373

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