Tsc22d3 TSC22 domain family, member 3 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Tsc22d3provided by RGD
Official Full Name: TSC22 domain family, member 3provided by RGD
Primary source: RGD:621654
See related: EnsemblRapid:ENSRNOG00000056135 AllianceGenome:RGD:621654
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Gilz; Dsipi
Summary: Involved in body fluid secretion. Predicted to be located in nucleus. Orthologous to human TSC22D3 (TSC22 domain family member 3). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Muscle (RPKM 469.6), Adrenal (RPKM 399.8) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: Xq32

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	X	NC_086039.1 (109006410..109066389, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	X	NC_051356.1 (104217898..104277886, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	X	NC_005120.4 (111884285..111944693, complement)

Chromosome X - NC_086039.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Glucocorticoid-induced leucine zipper protects noise-induced apoptosis in cochlear cells by inhibiting endoplasmic reticulum stress in rats.
Title: Glucocorticoid-induced leucine zipper protects noise-induced apoptosis in cochlear cells by inhibiting endoplasmic reticulum stress in rats.
Overexpression of GILZ by OE-GILZ-rLV transduction protected the retina from light-induced cellular damage by activating antiapoptotic pathways.
Title: Glucocorticoid-Induced Leucine Zipper Protects the Retina From Light-Induced Retinal Degeneration by Inducing Bcl-xL in Rats.
GILZ may be sensitive to the elevated expression of GC in septic muscle, promoting the expression and activation of GR involved in GC/GR-mediated proteolysis in septic skeletal muscle.
Title: Roles of GILZ in protein metabolism of L6 muscle cells exposed to serum from septic rats.
Our data demonstrate GILZ induction in cardiomyocytes both in vivo and in vitro by glucocorticoids, pointing to H9c2(2-1) cells as a valid model for studying the biological function of GILZ in cardiomyocytes.
Title: Expression of glucocorticoid-induced leucine zipper (GILZ) in cardiomyocytes.
the delta sleep-inducing peptide effect on c-Fos gene expression might be mediated by NMDA-receptors.
Title: Dizocilpine and cycloheximide prevent inhibition of c-Fos gene expression by delta sleep-inducing peptide in the paraventricular nucleus of the hypothalamus in rats with different resistance to emotional stress.
GILZ has an important role not only in adjusting adaptive responses to hypoxia by negatively regulating the activation of macrophages and the expression of proinflammatory cytokines
Title: Upregulations of glucocorticoid-induced leucine zipper by hypoxia and glucocorticoid inhibit proinflammatory cytokines under hypoxic conditions in macrophages.
In PC12 cells, dexamethasone treatment leads to a progressive increase of GILZ mRNA expression levels via a glucocorticoid receptor-dependent mechanism.
Title: Chromatin immunoprecipitation scanning identifies glucocorticoid receptor binding regions in the proximal promoter of a ubiquitously expressed glucocorticoid target gene in brain.
multiple GILZ isoforms are expressed in most cells and tissues and that these play distinct roles in regulating proliferation and ion transport.
Title: Differential activities of glucocorticoid-induced leucine zipper protein isoforms.
a role in blocking excitatory effects of glutamate on rat brain neurons
Title: Delta sleep-inducing peptide blocks excitatory effects of glutamate on rat brain neurons.
Induction of GILZ mRNA may play a permissive role in the enhancement of the early and/or late responses; these effects may be necessary for a full response but do not by themselves promote early changes in urinary Na(+) and K(+) excretion.
Title: Mineralocorticoid effects in the kidney: correlation between alphaENaC, GILZ, and Sgk-1 mRNA expression and urinary excretion of Na+ and K+.

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General gene information

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Gene Ontology Provided by RGD

Process	Evidence Code	Pubs
involved_in body fluid secretion	IEP Inferred from Expression Pattern more info	PubMed
involved_in negative regulation of activation-induced cell death of T cells	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of activation-induced cell death of T cells	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of activation-induced cell death of T cells	ISO Inferred from Sequence Orthology more info
involved_in regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
involved_in response to osmotic stress	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within response to osmotic stress	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: TSC22 domain family protein 3

Names: TSC22 domain family 3; delta sleep inducing peptide, immunoreactor; glucocorticoid-induced leucine zipper protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001400982.1 → NP_001387911.1 TSC22 domain family protein 3 isoform 1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000021

UniProtKB/TrEMBL

A0A8I5ZQF5

Conserved Domains (1) summary

cd21940
Location:122 → 199

ZIP_TSC22D3; leucine zipper domain found in TSC22 domain family protein 3
NM_001400983.1 → NP_001387912.1 TSC22 domain family protein 3 isoform 1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000021

UniProtKB/TrEMBL

A0A8I5ZQF5

Conserved Domains (1) summary

cd21940
Location:122 → 199

ZIP_TSC22D3; leucine zipper domain found in TSC22 domain family protein 3
NM_031345.2 → NP_112635.1 TSC22 domain family protein 3 isoform 2

See identical proteins and their annotated locations for NP_112635.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000021

UniProtKB/Swiss-Prot

Q9EQZ1

UniProtKB/TrEMBL

A6HLR6

Related

ENSRNOP00000072713.1, ENSRNOT00000085118.3

Conserved Domains (1) summary

pfam01166
Location:58 → 114

TSC22; TSC-22/dip/bun family

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086039.1 Reference GRCr8

Range

109006410..109066389 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_008773447.4 → XP_008771669.1 TSC22 domain family protein 3 isoform X1

See identical proteins and their annotated locations for XP_008771669.1

UniProtKB/TrEMBL

A0A8I5ZQF5

Conserved Domains (1) summary

cd21940
Location:122 → 199

ZIP_TSC22D3; leucine zipper domain found in TSC22 domain family protein 3
XM_006234249.5 → XP_006234311.1 TSC22 domain family protein 3 isoform X1

See identical proteins and their annotated locations for XP_006234311.1

UniProtKB/TrEMBL

A0A8I5ZQF5

Conserved Domains (1) summary

cd21940
Location:122 → 199

ZIP_TSC22D3; leucine zipper domain found in TSC22 domain family protein 3
XM_063280331.1 → XP_063136401.1 TSC22 domain family protein 3 isoform X2