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    TPST2 tyrosylprotein sulfotransferase 2 [ Homo sapiens (human) ]

    Gene ID: 8459, updated on 27-Nov-2024

    Summary

    Official Symbol
    TPST2provided by HGNC
    Official Full Name
    tyrosylprotein sulfotransferase 2provided by HGNC
    Primary source
    HGNC:HGNC:12021
    See related
    Ensembl:ENSG00000128294 MIM:603126; AllianceGenome:HGNC:12021
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    TPST-2; TANGO13B
    Summary
    The protein encoded by this gene catalyzes the O-sulfation of tyrosine residues within acidic regions of proteins. The encoded protein is a type II integral membrane protein found in the Golgi body. Alternative splicing produces multiple transcript variants encoding distinct isoforms. [provided by RefSeq, May 2018]
    Expression
    Ubiquitous expression in pancreas (RPKM 24.6), placenta (RPKM 15.2) and 24 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See TPST2 in Genome Data Viewer
    Location:
    22q12.1
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 22 NC_000022.11 (26521996..26590132, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 22 NC_060946.1 (26984404..27052464, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 22 NC_000022.10 (26917962..26986096, complement)

    Chromosome 22 - NC_000022.11Genomic Context describing neighboring genes Neighboring gene MED14-independent group 3 enhancer GRCh37_chr22:26889254-26890453 Neighboring gene SRR1 domain containing Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13570 Neighboring gene tuftelin interacting protein 11 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr22:26902046-26903245 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18792 Neighboring gene H3K27ac hESC enhancer GRCh37_chr22:26908724-26909261 Neighboring gene TFIP11 divergent transcript Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:26937311-26937812 Neighboring gene Sharpr-MPRA regulatory region 3066 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:26951753-26952722 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:26959537-26960060 Neighboring gene microRNA 548j Neighboring gene hESC enhancers GRCh37_chr22:26963727-26964250 and GRCh37_chr22:26964251-26964774 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:26964775-26965298 Neighboring gene high mobility group box 1 pseudogene 10 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18793 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancers GRCh37_chr22:26975739-26976656 and GRCh37_chr22:26976657-26977573 Neighboring gene H3K27ac hESC enhancer GRCh37_chr22:26985294-26985794 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13573 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18794 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18795 Neighboring gene crystallin beta A4 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:27003362-27004004 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18796 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13574 Neighboring gene crystallin beta B1 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr22:27009656-27010334 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:27013045-27013722 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:27014401-27015076 Neighboring gene CRISPRi-validated cis-regulatory element chr22.1058 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:27037805-27038669 Neighboring gene Sharpr-MPRA regulatory region 8650 Neighboring gene Sharpr-MPRA regulatory region 12592 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:27041123-27041688 Neighboring gene iron-sulfur cluster assembly 2 pseudogene 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env HIV-1 gp120 is sulfated at positions Y173 and Y177 in the V2 domain by tyrosyl sulfotransferase 2 (TPST2), leading to modulate gp120 epitope exposure and neutralization sensitivity PubMed
    env Sulfation of CCR5 by tyrosylprotein sulfotranferase-2 is crucial for mediating interaction with HIV-1 gp120. The pattern and the rate of sulfation for CCR5 depend on the number of amino acids N-terminal of Tyr-3 PubMed
    env The chemokine receptor CCR5 is posttranslationally modified by sulfation of its N-terminal tyrosines; sulfated tyrosines contribute to the binding of CCR5 to MIP-1 alpha, MIP-1 beta, and HIV-1 gp120/CD4 complexes and to the ability of HIV-1 to enter cells PubMed

    Go to the HIV-1, Human Interaction Database

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General protein information

    Preferred Names
    protein-tyrosine sulfotransferase 2
    Names
    transport and golgi organization 13 homolog B
    tyrosylprotein phosphotransferase 2
    NP_001008566.1
    NP_001349851.1
    NP_001349852.1
    NP_003586.3
    XP_024308062.1
    XP_047297505.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001008566.3NP_001008566.1  protein-tyrosine sulfotransferase 2 isoform 1

      See identical proteins and their annotated locations for NP_001008566.1

      Status: REVIEWED

      Source sequence(s)
      Z95115
      Consensus CDS
      CCDS13839.1
      UniProtKB/Swiss-Prot
      B3KQA7, O60704, Q6FI98, Q9H0V4
      UniProtKB/TrEMBL
      B7Z976
      Related
      ENSP00000381180.2, ENST00000398110.6
      Conserved Domains (1) summary
      pfam13469
      Location:71262
      Sulfotransfer_3; Sulfotransferase family
    2. NM_001362922.2NP_001349851.1  protein-tyrosine sulfotransferase 2 isoform 1

      Status: REVIEWED

      Source sequence(s)
      Z95115
      Consensus CDS
      CCDS13839.1
      UniProtKB/Swiss-Prot
      B3KQA7, O60704, Q6FI98, Q9H0V4
      UniProtKB/TrEMBL
      B7Z976
      Conserved Domains (1) summary
      pfam13469
      Location:71262
      Sulfotransfer_3; Sulfotransferase family
    3. NM_001362923.2NP_001349852.1  protein-tyrosine sulfotransferase 2 isoform 2

      Status: REVIEWED

      Source sequence(s)
      Z95115
      Conserved Domains (1) summary
      pfam13469
      Location:125316
      Sulfotransfer_3; Sulfotransferase family
    4. NM_003595.5NP_003586.3  protein-tyrosine sulfotransferase 2 isoform 1

      See identical proteins and their annotated locations for NP_003586.3

      Status: REVIEWED

      Source sequence(s)
      Z95115
      Consensus CDS
      CCDS13839.1
      UniProtKB/Swiss-Prot
      B3KQA7, O60704, Q6FI98, Q9H0V4
      UniProtKB/TrEMBL
      B7Z976
      Related
      ENSP00000339813.4, ENST00000338754.9
      Conserved Domains (1) summary
      pfam13469
      Location:71262
      Sulfotransfer_3; Sulfotransferase family

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000022.11 Reference GRCh38.p14 Primary Assembly

      Range
      26521996..26590132 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047441549.1XP_047297505.1  protein-tyrosine sulfotransferase 2 isoform X2

    2. XM_024452294.2XP_024308062.1  protein-tyrosine sulfotransferase 2 isoform X1

      Conserved Domains (1) summary
      pfam13469
      Location:141332
      Sulfotransfer_3; Sulfotransferase family

    RNA

    1. XR_007067981.1 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060946.1 Alternate T2T-CHM13v2.0

      Range
      26984404..27052464 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)