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    Ubap2 ubiquitin-associated protein 2 [ Mus musculus (house mouse) ]

    Gene ID: 68926, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Ubap2provided by MGI
    Official Full Name
    ubiquitin-associated protein 2provided by MGI
    Primary source
    MGI:MGI:1916176
    See related
    Ensembl:ENSMUSG00000028433 AllianceGenome:MGI:1916176
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    UBAP-2; mKIAA1491; 1190005K07Rik
    Summary
    Predicted to be located in chromosome. Predicted to be active in cytoplasm and nucleus. Orthologous to human UBAP2 (ubiquitin associated protein 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in testis adult (RPKM 65.5), thymus adult (RPKM 28.5) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Ubap2 in Genome Data Viewer
    Location:
    4 A5; 4 21.13 cM
    Exon count:
    31
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (41194313..41276016, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (41194313..41276016, complement)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E150 Neighboring gene STARR-positive B cell enhancer ABC_E6162 Neighboring gene nucleolar protein family 6 (RNA-associated) Neighboring gene ubiquitin-conjugating enzyme E2R 2 Neighboring gene STARR-seq mESC enhancer starr_10025 Neighboring gene predicted gene, 22888 Neighboring gene predicted gene, 24837 Neighboring gene predicted gene, 23090 Neighboring gene predicted gene 12401 Neighboring gene STARR-positive B cell enhancer ABC_E2108 Neighboring gene predicted gene, 42273 Neighboring gene DDB1 and CUL4 associated factor 12 Neighboring gene STARR-positive B cell enhancer ABC_E7963 Neighboring gene predicted gene, 26049

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Pancreatic Ubap2 deletion regulates glucose tolerance, inflammation, and protection from cerulein-induced pancreatitis. Roy RV, et al. Cancer Lett, 2023 Dec 1. PMID 37865160, Free PMC Article
    2. UBAP2 plays a role in bone homeostasis through the regulation of osteoblastogenesis and osteoclastogenesis. Kim J, et al. Nat Commun, 2023 Jun 20. PMID 37339951, Free PMC Article
    3. lingerer, a Drosophila gene involved in initiation and termination of copulation, encodes a set of novel cytoplasmic proteins. Kuniyoshi H, et al. Genetics, 2002 Dec. PMID 12524348, Free PMC Article
    4. The interactome of CLUH reveals its association to SPAG5 and its co-translational proximity to mitochondrial proteins. Hémono M, et al. BMC Biol, 2022 Jan 10. PMID 35012549, Free PMC Article
    5. Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2003 Aug 31. PMID 14621295

    See all (31) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Pancreatic Ubap2 deletion regulates glucose tolerance, inflammation, and protection from cerulein-induced pancreatitis.
      Title: Pancreatic Ubap2 deletion regulates glucose tolerance, inflammation, and protection from cerulein-induced pancreatitis.
    2. UBAP2 plays a role in bone homeostasis through the regulation of osteoblastogenesis and osteoclastogenesis.
      Title: UBAP2 plays a role in bone homeostasis through the regulation of osteoblastogenesis and osteoclastogenesis.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Targeted (1)  1 citation

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Component Evidence Code Pubs
    located_in chromosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    ubiquitin-associated protein 2
    Names
    MLig-1
    RNA polymerase II degradation factor Ubap2
    protein lingerer homolog 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001419187.1 → NP_001406116.1  ubiquitin-associated protein 2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL807823

    2. NM_001419188.1 → NP_001406117.1  ubiquitin-associated protein 2 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AL807823

    3. NM_001419189.1 → NP_001406118.1  ubiquitin-associated protein 2 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AL807823
      Related
      ENSMUSP00000121724.2, ENSMUST00000134782.2

    4. NM_001419190.1 → NP_001406119.1  ubiquitin-associated protein 2 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AL807823

    5. NM_001419191.1 → NP_001406120.1  ubiquitin-associated protein 2 isoform 6

      Status: VALIDATED

      Source sequence(s)
      AL807823

    6. NM_026872.2 → NP_081148.1  ubiquitin-associated protein 2 isoform 1

      See identical proteins and their annotated locations for NP_081148.1

      Status: VALIDATED

      Source sequence(s)
      AL807823
      Consensus CDS
      CCDS18058.1
      UniProtKB/Swiss-Prot
      Q812D6, Q91VX2, Q99K40
      UniProtKB/TrEMBL
      A2AMY5
      Related
      ENSMUSP00000030143.7, ENSMUST00000030143.13
      Conserved Domains (2) summary
      cd14277
      Location:53 → 90
      UBA_UBP2_like; UBA domain found in ubiquitin-associated protein 2 (UBAP-2) like proteins
      pfam12478
      Location:512 → 541
      DUF3697; Ubiquitin-associated protein 2

    RNA

    1. NR_185031.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL807823

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      41194313..41276016 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006538224.2 → XP_006538287.1  ubiquitin-associated protein 2 isoform X2

      See identical proteins and their annotated locations for XP_006538287.1

      UniProtKB/Swiss-Prot
      Q812D6, Q91VX2, Q99K40
      UniProtKB/TrEMBL
      A2AMY5
      Conserved Domains (2) summary
      cd14277
      Location:53 → 90
      UBA_UBP2_like; UBA domain found in ubiquitin-associated protein 2 (UBAP-2) like proteins
      pfam12478
      Location:512 → 541
      DUF3697; Ubiquitin-associated protein 2

    2. XM_006538225.5 → XP_006538288.1  ubiquitin-associated protein 2 isoform X3

      UniProtKB/TrEMBL
      A2AMY5
      Conserved Domains (2) summary
      cd14277
      Location:59 → 96
      UBA_UBP2_like; UBA domain found in ubiquitin-associated protein 2 (UBAP-2) like proteins
      pfam12478
      Location:518 → 547
      DUF3697; Ubiquitin-associated protein 2
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q91VX2.1 GenPept UniProtKB/Swiss-Prot:Q91VX2

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