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    alcama activated leukocyte cell adhesion molecule a [ Danio rerio (zebrafish) ]

    Gene ID: 30194, updated on 9-Dec-2024

    Summary

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    Official Symbol
    alcamaprovided by ZNC
    Official Full Name
    activated leukocyte cell adhesion molecule aprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-990415-30
    See related
    Ensembl:ENSDARG00000026531 AllianceGenome:ZFIN:ZDB-GENE-990415-30
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    alcam; cd166; DM-GRASP
    Summary
    Enables identical protein binding activity. Involved in several processes, including cartilage morphogenesis; neural crest cell differentiation; and positive regulation of cell morphogenesis. Acts upstream of or within axonogenesis; embryonic organ morphogenesis; and retina morphogenesis in camera-type eye. Located in axon. Is expressed in several structures, including digestive system; immature eye; musculature system; nervous system; and pericardial region. Orthologous to human ALCAM (activated leukocyte cell adhesion molecule). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See alcama in Genome Data Viewer
    Location:
    chromosome: 10
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 10 NC_007121.7 (28731749..28835782, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 10 NC_007121.6 (28845128..28949151, complement)

    Chromosome 10 - NC_007121.7Genomic Context describing neighboring genes Neighboring gene Cbl proto-oncogene B, E3 ubiquitin protein ligase Neighboring gene uncharacterized LOC110440072 Neighboring gene uncharacterized LOC103911755 Neighboring gene uncharacterized LOC137496546 Neighboring gene si:ch211-103f14.3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Spatiotemporal pattern of retinal ganglion cell differentiation revealed by the expression of neurolin in embryonic zebrafish. Laessing U, et al. J Neurobiol, 1996 Jan. PMID 8748372
    2. Movement disorder and neuromuscular change in zebrafish embryos after exposure to caffeine. Chen YH, et al. Neurotoxicol Teratol, 2008 Sep-Oct. PMID 18508234
    3. A role for alpha1 tubulin-expressing Müller glia in regeneration of the injured zebrafish retina. Fausett BV, et al. J Neurosci, 2006 Jun 7. PMID 16763038, Free PMC Article
    4. Polarization and orientation of retinal ganglion cells in vivo. Zolessi FR, et al. Neural Dev, 2006 Oct 13. PMID 17147778, Free PMC Article
    5. Semaphorin 3d guides laterality of retinal ganglion cell projections in zebrafish. Sakai JA, et al. Development, 2006 Mar. PMID 16467361

    See all (140) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Alcama mediates Edn1 signaling during zebrafish cartilage morphogenesis.
      Title: Alcama mediates Edn1 signaling during zebrafish cartilage morphogenesis.
    2. Results suggest that the zebrafish Neurolin-a and -b paralogs are involved in distinct steps of retinotectal development.
      Title: Zebrafish neurolin-a and -b, orthologs of ALCAM, are involved in retinal ganglion cell differentiation and retinal axon pathfinding.
    3. Muscle pioneer fibres express neurolin but not NLCAM at high level.
      Title: Comparison of neurolin (ALCAM) and neurolin-like cell adhesion molecule (NLCAM) expression in zebrafish.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables identical protein binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within adaptive immune response IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within axonogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cartilage morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cell adhesion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within cell adhesion IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within embryonic viscerocranium morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within heart looping IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within immune system process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within neural crest cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in neural crest cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within neuron differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of cell morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within retina morphogenesis in camera-type eye IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in axon IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in axon IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cell projection IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in dendrite IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    CD166 antigen homolog A
    Names
    DM-GRASP homolog
    neurolin
    neurolin-a
    zn5 / zn-5 antigen
    zn8 / zn-8 antigen

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_131000.1 → NP_571075.1  CD166 antigen homolog A precursor

      See identical proteins and their annotated locations for NP_571075.1

      Status: PROVISIONAL

      Source sequence(s)
      L25273
      UniProtKB/Swiss-Prot
      Q90460, Q90480
      Related
      ENSDARP00000152888.1, ENSDART00000192220.1
      Conserved Domains (7) summary
      smart00406
      Location:306 → 387
      IGv; Immunoglobulin V-Type
      smart00410
      Location:254 → 322
      IG_like; Immunoglobulin like
      pfam07679
      Location:406 → 485
      I-set; Immunoglobulin I-set domain
      pfam01034
      Location:506 → 554
      Syndecan; Syndecan domain
      pfam08205
      Location:134 → 221
      C2-set_2; CD80-like C2-set immunoglobulin domain
      pfam13895
      Location:247 → 323
      Ig_2; Immunoglobulin domain
      cl11960
      Location:424 → 477
      Ig; Immunoglobulin domain

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007121.7 Reference GRCz11 Primary Assembly

      Range
      28731749..28835782 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005172635.5 → XP_005172692.1  CD166 antigen homolog A isoform X1

      UniProtKB/TrEMBL
      A0A2R8PV55, A0A8M2BJY9
      Related
      ENSDARP00000144664.1, ENSDART00000188436.1
      Conserved Domains (7) summary
      smart00406
      Location:306 → 387
      IGv; Immunoglobulin V-Type
      smart00410
      Location:254 → 322
      IG_like; Immunoglobulin like
      pfam07679
      Location:406 → 485
      I-set; Immunoglobulin I-set domain
      pfam01034
      Location:497 → 545
      Syndecan; Syndecan domain
      pfam08205
      Location:134 → 221
      C2-set_2; CD80-like C2-set immunoglobulin domain
      pfam13895
      Location:247 → 323
      Ig_2; Immunoglobulin domain
      cl11960
      Location:424 → 477
      Ig; Immunoglobulin domain

    Reference GRCz11 ALT_DRER_TU_2

    Genomic

    1. NW_018395290.1 Reference GRCz11 ALT_DRER_TU_2

      Range
      239509..268579 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q90460.1 GenPept UniProtKB/Swiss-Prot:Q90460

    Gene LinkOut

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