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    SH3RF1 SH3 domain containing ring finger 1 [ Equus caballus (horse) ]

    Gene ID: 100061339, updated on 17-Aug-2024

    Summary

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    Official Symbol
    SH3RF1provided by VGNC
    Official Full Name
    SH3 domain containing ring finger 1provided by VGNC
    Primary source
    VGNC:VGNC:22947
    See related
    Ensembl:ENSECAG00000021240
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Equus caballus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus
    Orthologs
    human mouse all
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    Genomic context

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    See SH3RF1 in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_08 current EquCab3.0 (GCF_002863925.1) 2 NC_009145.3 (66321759..66506737)

    Chromosome 2 - NC_009145.3Genomic Context describing neighboring genes Neighboring gene U6 spliceosomal RNA Neighboring gene NIMA related kinase 1 Neighboring gene divergent paired-related homeobox-like Neighboring gene ATP synthase F(0) complex subunit B1, mitochondrial pseudogene Neighboring gene small nucleolar RNA SNORA31 Neighboring gene carbonyl reductase 4 Neighboring gene palladin, cytoskeletal associated protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_009145.3 Chromosome 2 Reference EquCab3.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Molecular characterization of the apoptosis-related SH3RF1 and SH3RF2 genes and their association with exercise performance in Arabian horses. Ropka-Molik K, et al. BMC Vet Res, 2018 Aug 14. PMID 30107803, Free PMC Article
    2. Annotation of the Protein Coding Regions of the Equine Genome. Hestand MS, et al. PLoS One, 2015. PMID 26107351, Free PMC Article
    3. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    4. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. A non-significant decrease in SH3RF1 gene expression following the training periods was observed
      Title: Molecular characterization of the apoptosis-related SH3RF1 and SH3RF2 genes and their association with exercise performance in Arabian horses.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables protein binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables ubiquitin protein ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in positive regulation of JNK cascade IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    E3 ubiquitin-protein ligase SH3RF1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_002863925.1-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference EquCab3.0 Primary Assembly

    Genomic

    1. NC_009145.3 Reference EquCab3.0 Primary Assembly

      Range
      66321759..66506737
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_023636317.1 → XP_023492085.1  E3 ubiquitin-protein ligase SH3RF1 isoform X1

      UniProtKB/TrEMBL
      A0A9L0RNR6, A0A9L0T6G5
      Conserved Domains (6) summary
      cd11785
      Location:842 → 896
      SH3_SH3RF_C; C-terminal (Fourth) Src Homology 3 domain of SH3 domain containing ring finger 1 (SH3RF1), SH3RF3, and similar domains
      cd11926
      Location:458 → 512
      SH3_SH3RF1_3; Third Src Homology 3 domain of SH3 domain containing ring finger 1, an E3 ubiquitin-protein ligase
      cd11930
      Location:211 → 265
      SH3_SH3RF1_2; Second Src Homology 3 domain of SH3 domain containing ring finger protein 1, an E3 ubiquitin-protein ligase
      cd16748
      Location:8 → 55
      RING-HC_SH3RF1; RING finger, HC subclass, found in SH3 domain-containing RING finger protein 1 (SH3RF1) and similar proteins
      cl17036
      Location:148 → 201
      SH3; Src Homology 3 domain superfamily
      cl26464
      Location:512 → 830
      Atrophin-1; Atrophin-1 family

    2. XM_023636316.1 → XP_023492084.1  E3 ubiquitin-protein ligase SH3RF1 isoform X1

      UniProtKB/TrEMBL
      A0A9L0RNR6, A0A9L0T6G5
      Related
      ENSECAP00000082691.1, ENSECAT00000148099.1
      Conserved Domains (6) summary
      cd11785
      Location:842 → 896
      SH3_SH3RF_C; C-terminal (Fourth) Src Homology 3 domain of SH3 domain containing ring finger 1 (SH3RF1), SH3RF3, and similar domains
      cd11926
      Location:458 → 512
      SH3_SH3RF1_3; Third Src Homology 3 domain of SH3 domain containing ring finger 1, an E3 ubiquitin-protein ligase
      cd11930
      Location:211 → 265
      SH3_SH3RF1_2; Second Src Homology 3 domain of SH3 domain containing ring finger protein 1, an E3 ubiquitin-protein ligase
      cd16748
      Location:8 → 55
      RING-HC_SH3RF1; RING finger, HC subclass, found in SH3 domain-containing RING finger protein 1 (SH3RF1) and similar proteins
      cl17036
      Location:148 → 201
      SH3; Src Homology 3 domain superfamily
      cl26464
      Location:512 → 830
      Atrophin-1; Atrophin-1 family

    3. XM_023636318.1 → XP_023492086.1  E3 ubiquitin-protein ligase SH3RF1 isoform X2

      UniProtKB/TrEMBL
      A0A9L0RNR6
      Related
      ENSECAP00000063368.1, ENSECAT00000144739.1
      Conserved Domains (5) summary
      cd11785
      Location:831 → 885
      SH3_SH3RF_C; C-terminal (Fourth) Src Homology 3 domain of SH3 domain containing ring finger 1 (SH3RF1), SH3RF3, and similar domains
      cd11930
      Location:200 → 254
      SH3_SH3RF1_2; Second Src Homology 3 domain of SH3 domain containing ring finger protein 1, an E3 ubiquitin-protein ligase
      cd16748
      Location:8 → 55
      RING-HC_SH3RF1; RING finger, HC subclass, found in SH3 domain-containing RING finger protein 1 (SH3RF1) and similar proteins
      cl17036
      Location:447 → 501
      SH3; Src Homology 3 domain superfamily
      cl26464
      Location:501 → 819
      Atrophin-1; Atrophin-1 family

    RNA

    1. XR_002806445.1 RNA Sequence

    2. XR_002806444.1 RNA Sequence

    Nucleotide Protein
    Heading Accession and Version

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