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    Pja1 praja ring finger ubiquitin ligase 1 [ Mus musculus (house mouse) ]

    Gene ID: 18744, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Pja1provided by MGI
    Official Full Name
    praja ring finger ubiquitin ligase 1provided by MGI
    Primary source
    MGI:MGI:1101765
    See related
    Ensembl:ENSMUSG00000034403 AllianceGenome:MGI:1101765
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    praja-1
    Summary
    Enables ubiquitin protein ligase activity. Acts upstream of or within protein catabolic process. Located in cytoplasm. Is expressed in several structures, including central nervous system; dorsal root ganglion; ear; genitourinary system; and liver. Orthologous to human PJA1 (praja ring finger ubiquitin ligase 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in CNS E18 (RPKM 68.1), CNS E14 (RPKM 57.5) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Pja1 in Genome Data Viewer
    Location:
    X C3; X 43.38 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (98509344..98514874, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (99465734..99471268, complement)

    Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene predicted gene, 30798 Neighboring gene predicted gene 14808 Neighboring gene STARR-seq mESC enhancer starr_47622 Neighboring gene STARR-seq mESC enhancer starr_47623 Neighboring gene VISTA enhancer mm1347 Neighboring gene predicted gene, 31155 Neighboring gene CapStarr-seq enhancer MGSCv37_chrX:96777370-96777593 Neighboring gene predicted gene 14816

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Identification of genes expressed in the amygdala during the formation of fear memory. Stork O, et al. Learn Mem, 2001 Jul-Aug. PMID 11533224, Free PMC Article
    2. Distinct regions of Praja-1 E3 ubiquitin-protein ligase selectively bind to docosahexaenoic acid-containing phosphatidic acid and diacylglycerol kinase δ. Numagami Y, et al. Biochim Biophys Acta Mol Cell Biol Lipids, 2023 Mar. PMID 36528254
    3. 1-Stearoyl-2-docosahexaenoyl-phosphatidic acid interacts with and activates Praja-1, the E3 ubiquitin ligase acting on the serotonin transporter in the brain. Lu Q, et al. FEBS Lett, 2020 Jun. PMID 32134507
    4. Praja1 RING-finger E3 ubiquitin ligase suppresses neuronal cytoplasmic TDP-43 aggregate formation. Watabe K, et al. Neuropathology, 2020 Dec. PMID 32686212, Free PMC Article
    5. Targeting the E3 Ubiquitin Ligase PJA1 Enhances Tumor-Suppressing TGFβ Signaling. Chen J, et al. Cancer Res, 2020 May 1. PMID 32127355, Free PMC Article

    See all (39) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. PJA1 mediates the effects of astrocytic GPR30 on learning and memory in female mice.
      Title: PJA1 mediates the effects of astrocytic GPR30 on learning and memory in female mice.
    2. Praja1 RING-finger E3 ubiquitin ligase suppresses neuronal cytoplasmic TDP-43 aggregate formation.
      Title: Praja1 RING-finger E3 ubiquitin ligase suppresses neuronal cytoplasmic TDP-43 aggregate formation.
    3. 1-Stearoyl-2-docosahexaenoyl-phosphatidic acid interacts with and activates Praja-1, the E3 ubiquitin ligase acting on the serotonin transporter in the brain.
      Title: 1-Stearoyl-2-docosahexaenoyl-phosphatidic acid interacts with and activates Praja-1, the E3 ubiquitin ligase acting on the serotonin transporter in the brain.
    4. Praja1 promotes skeletal myogenesis through degradation of EZH2 upon p38alpha activation.
      Title: Praja1 E3 ubiquitin ligase promotes skeletal myogenesis through degradation of EZH2 upon p38α activation.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Chemically induced (ENU) (1) 
    • Endonuclease-mediated (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin protein ligase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within protein catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein ubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    E3 ubiquitin-protein ligase Praja-1
    Names
    RING-type E3 ubiquitin transferase Praja-1
    praja ring finger 1, E3 ubiquitin protein ligase
    praja1, RING-H2 motif containing
    NP_001076579.1
    NP_001277484.1
    NP_001277485.1
    NP_001412854.1
    NP_001412855.1
    NP_001412856.1
    NP_032879.2
    XP_011245846.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001083110.3 → NP_001076579.1  E3 ubiquitin-protein ligase Praja-1 isoform 1

      See identical proteins and their annotated locations for NP_001076579.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes isoform 1. Variants 1 and 5 both encode the same isoform (1).
      Source sequence(s)
      AL831752
      Consensus CDS
      CCDS41070.1
      UniProtKB/Swiss-Prot
      O55176, Q8CFU2, Q99MJ1, Q99MJ2, Q99MJ3, Q9DB04
      UniProtKB/TrEMBL
      Q05CG5, Q3UXQ1
      Related
      ENSMUSP00000132393.2, ENSMUST00000167246.2
      Conserved Domains (1) summary
      cd16465
      Location:529 → 574
      RING-H2_PJA1_2; RING finger, H2 subclass, found in protein E3 ubiquitin-protein ligase Praja-1, Praja-2, and similar proteins

    2. NM_001290555.2 → NP_001277484.1  E3 ubiquitin-protein ligase Praja-1 isoform 3

      See identical proteins and their annotated locations for NP_001277484.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (3) has a longer N-terminus than isoform 1.
      Source sequence(s)
      AL831752
      UniProtKB/TrEMBL
      Q3UXQ1
      Related
      ENSMUSP00000109420.2, ENSMUST00000036354.7
      Conserved Domains (1) summary
      cd16465
      Location:566 → 611
      RING-H2_PJA1_2; RING finger, H2 subclass, found in protein E3 ubiquitin-protein ligase Praja-1, Praja-2, and similar proteins

    3. NM_001290556.2 → NP_001277485.1  E3 ubiquitin-protein ligase Praja-1 isoform 4

      See identical proteins and their annotated locations for NP_001277485.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) lacks an alternate in-frame segment, compared to variant 1. The encoded isoform (4) is shorter than isoform 1. Variants 4 and 7 both encode the same isoform (4).
      Source sequence(s)
      AL831752
      Consensus CDS
      CCDS81157.1
      UniProtKB/TrEMBL
      A0JLS7, B1AXU4
      Related
      ENSMUSP00000109421.2, ENSMUST00000113790.8
      Conserved Domains (2) summary
      pfam13639
      Location:350 → 391
      zf-RING_2; Ring finger domain
      cl17018
      Location:317 → 350
      FANC; Fanconi anemia ID complex proteins FANCI and FANCD2

    4. NM_001425925.1 → NP_001412854.1  E3 ubiquitin-protein ligase Praja-1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AL831752
      UniProtKB/Swiss-Prot
      O55176, Q8CFU2, Q99MJ1, Q99MJ2, Q99MJ3, Q9DB04
      UniProtKB/TrEMBL
      Q05CG5, Q3UXQ1

    5. NM_001425926.1 → NP_001412855.1  E3 ubiquitin-protein ligase Praja-1 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AL831752

    6. NM_001425927.1 → NP_001412856.1  E3 ubiquitin-protein ligase Praja-1 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AL831752
      UniProtKB/TrEMBL
      A0JLS7, B1AXU4

    7. NM_008853.4 → NP_032879.2  E3 ubiquitin-protein ligase Praja-1 isoform 2

      See identical proteins and their annotated locations for NP_032879.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame segment, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
      Source sequence(s)
      AL831752
      Consensus CDS
      CCDS41071.1
      UniProtKB/TrEMBL
      A0JLS7, B1AXU3
      Related
      ENSMUSP00000109428.4, ENSMUST00000113797.4
      Conserved Domains (2) summary
      pfam13639
      Location:347 → 388
      zf-RING_2; Ring finger domain
      cl17018
      Location:314 → 347
      FANC; Fanconi anemia ID complex proteins FANCI and FANCD2

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000086.8 Reference GRCm39 C57BL/6J

      Range
      98509344..98514874 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011247544.1 → XP_011245846.1  E3 ubiquitin-protein ligase Praja-1 isoform X1

      See identical proteins and their annotated locations for XP_011245846.1

      UniProtKB/TrEMBL
      Q3UXQ1
      Related
      ENSMUSP00000109423.2, ENSMUST00000113792.2
      Conserved Domains (1) summary
      cd16465
      Location:566 → 611
      RING-H2_PJA1_2; RING finger, H2 subclass, found in protein E3 ubiquitin-protein ligase Praja-1, Praja-2, and similar proteins
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O55176.3 GenPept UniProtKB/Swiss-Prot:O55176

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