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    Dtd1 D-tyrosyl-tRNA deacylase 1 [ Mus musculus (house mouse) ]

    Gene ID: 66044, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Dtd1provided by MGI
    Official Full Name
    D-tyrosyl-tRNA deacylase 1provided by MGI
    Primary source
    MGI:MGI:1913294
    See related
    Ensembl:ENSMUSG00000027430 AllianceGenome:MGI:1913294
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    DTD; DUE-B; Hars2; 0610006H08Rik
    Summary
    Predicted to enable D-tyrosyl-tRNA(Tyr) deacylase activity and DNA binding activity. Predicted to be involved in DNA duplex unwinding and tRNA metabolic process. Predicted to be located in nucleus. Predicted to be active in cytoplasm. Is expressed in several structures, including alimentary system; nervous system; respiratory system; sensory organ; and urinary system. Orthologous to human DTD1 (D-aminoacyl-tRNA deacylase 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in CNS E18 (RPKM 18.3), cerebellum adult (RPKM 17.4) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Dtd1 in Genome Data Viewer
    Location:
    2 G1; 2 71.02 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (144441873..144610667)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (144599953..144768747)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E1603 Neighboring gene predicted gene, 34292 Neighboring gene SEC23 homolog B, COPII coat complex component Neighboring gene small integral membrane protein 26 Neighboring gene STARR-seq mESC enhancer starr_05919 Neighboring gene CWC22 spliceosome-associated protein homolog pseudogene Neighboring gene predicted gene, 39951 Neighboring gene STARR-seq mESC enhancer starr_05920 Neighboring gene SCP2 sterol-binding domain containing 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. NOVA-dependent regulation of cryptic NMD exons controls synaptic protein levels after seizure. Eom T, et al. Elife, 2013 Jan 22. PMID 23359859, Free PMC Article
    2. Hdac4 Interactions in Huntington's Disease Viewed Through the Prism of Multiomics. Federspiel JD, et al. Mol Cell Proteomics, 2019 Aug 9. PMID 31040226, Free PMC Article
    3. EUCOMM--the European conditional mouse mutagenesis program. Friedel RH, et al. Brief Funct Genomic Proteomic, 2007 Sep. PMID 17967808
    4. GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Visel A, et al. Nucleic Acids Res, 2004 Jan 1. PMID 14681479, Free PMC Article
    5. Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray. Tanaka TS, et al. Proc Natl Acad Sci U S A, 2000 Aug 1. PMID 10922068, Free PMC Article

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Gene trapped (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables D-tyrosyl-tRNA(Tyr) deacylase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables D-tyrosyl-tRNA(Tyr) deacylase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables tRNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA duplex unwinding ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in DNA replication IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in aminoacyl-tRNA metabolism involved in translational fidelity IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in tRNA metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    D-aminoacyl-tRNA deacylase 1
    Names
    D-tyrosyl-tRNA deacylase 1 homolog
    D-tyrosyl-tRNA(Tyr) deacylase 1
    DNA-unwinding element-binding protein B
    gly-tRNA(Ala) deacylase
    NP_079590.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_025314.3 → NP_079590.1  D-aminoacyl-tRNA deacylase 1

      See identical proteins and their annotated locations for NP_079590.1

      Status: VALIDATED

      Source sequence(s)
      AK003594, AK011917, BE633558, BY294360
      Consensus CDS
      CCDS16824.1
      UniProtKB/Swiss-Prot
      A2ANA2, Q3TY44, Q9CRE8, Q9CYL0, Q9D013, Q9D1G4, Q9DD18
      Related
      ENSMUSP00000028917.7, ENSMUST00000028917.7
      Conserved Domains (1) summary
      cd00563
      Location:1 → 147
      Dtyr_deacylase; D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      144441873..144610667
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9DD18.2 GenPept UniProtKB/Swiss-Prot:Q9DD18

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