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    Septin6 septin 6 [ Mus musculus (house mouse) ]

    Gene ID: 56526, updated on 9-Dec-2024

    Summary

    Official Symbol
    Septin6provided by MGI
    Official Full Name
    septin 6provided by MGI
    Primary source
    MGI:MGI:1888939
    See related
    Ensembl:ENSMUSG00000050379 AllianceGenome:MGI:1888939
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Sep6; Sept6; mKIAA0128; 2810035H17Rik; C920001C06Rik
    Summary
    Predicted to enable GTPase activity and molecular adaptor activity. Predicted to be involved in cilium assembly; cytoskeleton-dependent cytokinesis; and protein localization. Located in several cellular components, including cleavage furrow; septin cytoskeleton; and synaptic vesicle. Part of septin complex. Is active in presynapse. Is expressed in alimentary system; central nervous system; genitourinary system; sensory organ; and thymus. Orthologous to human SEPTIN6 (septin 6). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in thymus adult (RPKM 14.7), CNS E18 (RPKM 10.5) and 20 other tissues See more
    Orthologs
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    Genomic context

    See Septin6 in Genome Data Viewer
    Location:
    X A3.3; X 21.32 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (36174925..36253711, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (36911272..36990036, complement)

    Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene ubiquitin-conjugating enzyme E2A Neighboring gene STARR-positive B cell enhancer ABC_E11047 Neighboring gene NF-kappaB repressing factor Neighboring gene predicted gene 15008 Neighboring gene STARR-seq mESC enhancer starr_47007 Neighboring gene CapStarr-seq enhancer MGSCv37_chrX:34520906-34521122 Neighboring gene sosondowah ankyrin repeat domain family member D Neighboring gene predicted gene, 26099

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Related articles in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (3)  1 citation

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • KIAA0128

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables molecular adaptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cell division IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cytoskeleton-dependent cytokinesis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in protein localization IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in spermatogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in axon terminus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in cell division site IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cleavage furrow IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in kinetochore IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in microtubule cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in midbody IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in presynapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in septin collar IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of septin complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of septin complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of septin complex ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in septin ring IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in septin ring IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in sperm annulus IEA
    Inferred from Electronic Annotation
    more info
     
    located_in sperm annulus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in spindle IEA
    Inferred from Electronic Annotation
    more info
     
    located_in synaptic vesicle IDA
    Inferred from Direct Assay
    more info
    PubMed 

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001177323.2NP_001170794.1  septin-6 isoform 3

      See identical proteins and their annotated locations for NP_001170794.1

      Status: VALIDATED

      Source sequence(s)
      AK048455, BM245544, BY776992
      UniProtKB/TrEMBL
      Q3UUU4
      Conserved Domains (2) summary
      cd01850
      Location:38306
      CDC_Septin; CDC/Septin GTPase family
      COG5019
      Location:20372
      CDC3; Septin family protein [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]
    2. NM_001177324.1NP_001170795.1  septin-6 isoform 1

      See identical proteins and their annotated locations for NP_001170795.1

      Status: VALIDATED

      Source sequence(s)
      AK012858, AK162755, AK172894, BY776992, CJ312154
      Consensus CDS
      CCDS53051.1
      UniProtKB/Swiss-Prot
      A2A3V9, A2A3W0, Q3TRH9, Q3TUA2, Q542H3, Q6A0C4, Q8C2L2, Q8C848, Q91XH2, Q9CZ94, Q9R1T4
      UniProtKB/TrEMBL
      Q3UUU4
      Related
      ENSMUSP00000110894.4, ENSMUST00000115239.10
      Conserved Domains (2) summary
      cd01850
      Location:39307
      CDC_Septin; CDC/Septin GTPase family
      COG5019
      Location:21373
      CDC3; Septin family protein [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]
    3. NM_001253706.1NP_001240635.1  septin-6 isoform 4

      See identical proteins and their annotated locations for NP_001240635.1

      Status: VALIDATED

      Source sequence(s)
      AK172894, BY776992, CN459422
      Consensus CDS
      CCDS57749.1
      UniProtKB/TrEMBL
      Q3UUU4
      Related
      ENSMUSP00000054034.5, ENSMUST00000053456.11
      Conserved Domains (1) summary
      cd01850
      Location:39307
      CDC_Septin; CDC/Septin GTPase family
    4. NM_001359140.1NP_001346069.1  septin-6 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AL450399
      Consensus CDS
      CCDS57749.1
      UniProtKB/TrEMBL
      Q3UUU4
      Conserved Domains (1) summary
      cd01850
      Location:39307
      CDC_Septin; CDC/Septin GTPase family
    5. NM_001359141.1NP_001346070.1  septin-6 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AL450399
      UniProtKB/TrEMBL
      Q3UUU4
      Conserved Domains (1) summary
      cd01850
      Location:39298
      CDC_Septin; CDC/Septin GTPase family
    6. NM_001359142.1NP_001346071.1  septin-6 isoform 6

      Status: VALIDATED

      Source sequence(s)
      AL450399
      UniProtKB/TrEMBL
      Q3UUU4
      Conserved Domains (1) summary
      cd01850
      Location:39298
      CDC_Septin; CDC/Septin GTPase family
    7. NM_019942.5NP_064326.2  septin-6 isoform 2

      See identical proteins and their annotated locations for NP_064326.2

      Status: VALIDATED

      Source sequence(s)
      AK048455, AK160884, BM245544, BY776992
      Consensus CDS
      CCDS30066.1
      UniProtKB/TrEMBL
      Q3UUU4
      Related
      ENSMUSP00000062014.8, ENSMUST00000060474.14
      Conserved Domains (2) summary
      cd01850
      Location:39307
      CDC_Septin; CDC/Septin GTPase family
      COG5019
      Location:21373
      CDC3; Septin family protein [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000086.8 Reference GRCm39 C57BL/6J

      Range
      36174925..36253711 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036162051.1XP_036017944.1  septin-6 isoform X4

      UniProtKB/TrEMBL
      Q3UUU4
      Conserved Domains (1) summary
      cd01850
      Location:39298
      CDC_Septin; CDC/Septin GTPase family
    2. XM_030251429.2XP_030107289.1  septin-6 isoform X5

      UniProtKB/TrEMBL
      Q3UUU4
      Conserved Domains (1) summary
      cd01850
      Location:39298
      CDC_Septin; CDC/Septin GTPase family
    3. XM_006541388.4XP_006541451.1  septin-6 isoform X1

      UniProtKB/TrEMBL
      Q3UUU4
      Conserved Domains (1) summary
      cd01850
      Location:39307
      CDC_Septin; CDC/Septin GTPase family
    4. XM_006541390.4XP_006541453.1  septin-6 isoform X2

      See identical proteins and their annotated locations for XP_006541453.1

      UniProtKB/TrEMBL
      Q3UUU4
      Conserved Domains (1) summary
      cd01850
      Location:39307
      CDC_Septin; CDC/Septin GTPase family
    5. XM_006541391.4XP_006541454.1  septin-6 isoform X3

      UniProtKB/TrEMBL
      Q3UUU4
      Conserved Domains (1) summary
      cd01850
      Location:39298
      CDC_Septin; CDC/Septin GTPase family