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    Cep76 centrosomal protein 76 [ Mus musculus (house mouse) ]

    Gene ID: 225659, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Cep76provided by MGI
    Official Full Name
    centrosomal protein 76provided by MGI
    Primary source
    MGI:MGI:1923401
    See related
    Ensembl:ENSMUSG00000073542 AllianceGenome:MGI:1923401
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    9630013E05; 6230425F05Rik
    Summary
    Predicted to be involved in regulation of centriole replication. Predicted to be located in centrosome. Predicted to be part of protein-containing complex. Predicted to be active in centriole. Is expressed in cerebral cortex ventricular layer; ductus deferens; prostate gland; and testis. Orthologous to human CEP76 (centrosomal protein 76). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in liver E14 (RPKM 12.6), liver E14.5 (RPKM 11.9) and 24 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Cep76 in Genome Data Viewer
    Location:
    18 E1; 18 40.04 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (67750034..67774425, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (67616964..67641355, complement)

    Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene PRELI domain containing 3A Neighboring gene spire type actin nucleation factor 1 Neighboring gene STARR-seq mESC enhancer starr_44904 Neighboring gene STARR-seq mESC enhancer starr_44905 Neighboring gene STARR-seq mESC enhancer starr_44907 Neighboring gene predicted gene, 17669 Neighboring gene STARR-positive B cell enhancer mm9_chr18:67771962-67772263 Neighboring gene proteasome (prosome, macropain) assembly chaperone 2 Neighboring gene protein tyrosine phosphatase, non-receptor type 2 Neighboring gene STARR-positive B cell enhancer ABC_E11000 Neighboring gene STARR-positive B cell enhancer ABC_E8723

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. The CP110-interacting proteins Talpid3 and Cep290 play overlapping and distinct roles in cilia assembly. Kobayashi T, et al. J Cell Biol, 2014 Jan 20. PMID 24421332, Free PMC Article
    2. Systematic analysis of human protein complexes identifies chromosome segregation proteins. Hutchins JR, et al. Science, 2010 Apr 30. PMID 20360068, Free PMC Article
    3. High-throughput discovery of novel developmental phenotypes. Dickinson ME, et al. Nature, 2016 Sep 22. PMID 27626380, Free PMC Article
    4. The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. Koscielny G, et al. Nucleic Acids Res, 2014 Jan. PMID 24194600, Free PMC Article
    5. Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development. Bedogni F, et al. Front Mol Neurosci, 2021. PMID 34321999, Free PMC Article

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 
    • Targeted (2) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of centriole replication IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of centriole replication ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of centriole replication ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in centriole IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in centriole ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in centriole ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in centrosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    centrosomal protein of 76 kDa

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001081073.2 → NP_001074542.1  centrosomal protein of 76 kDa isoform 1

      See identical proteins and their annotated locations for NP_001074542.1

      Status: VALIDATED

      Source sequence(s)
      AC120410
      Consensus CDS
      CCDS37850.1
      UniProtKB/Swiss-Prot
      Q0VEJ0
      Related
      ENSMUSP00000095149.3, ENSMUST00000097542.4
      Conserved Domains (2) summary
      pfam01841
      Location:365 → 411
      Transglut_core; Transglutaminase-like superfamily
      pfam15627
      Location:101 → 258
      CEP76-C2; CEP76 C2 domain

    2. NM_001357523.1 → NP_001344452.1  centrosomal protein of 76 kDa isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC120410
      Conserved Domains (2) summary
      pfam01841
      Location:187 → 233
      Transglut_core; Transglutaminase-like superfamily
      pfam15627
      Location:1 → 80
      CEP76-C2; CEP76 C2 domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000084.7 Reference GRCm39 C57BL/6J

      Range
      67750034..67774425 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q0VEJ0.1 GenPept UniProtKB/Swiss-Prot:Q0VEJ0

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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