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    DDC dopa decarboxylase [ Bos taurus (domestic cattle) ]

    Gene ID: 280762, updated on 3-Dec-2024

    Summary

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    Official Symbol
    DDCprovided by VGNC
    Official Full Name
    dopa decarboxylaseprovided by VGNC
    Primary source
    VGNC:VGNC:55748
    See related
    BGD:BT28956; Ensembl:ENSBTAG00000020869
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Orthologs
    human mouse all
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    Genomic context

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    See DDC in Genome Data Viewer
    Location:
    chromosome: 4
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 4 NC_037331.1 (5335520..5441303)

    Chromosome 4 - NC_037331.1Genomic Context describing neighboring genes Neighboring gene cordon-bleu WH2 repeat protein Neighboring gene growth factor receptor bound protein 10 Neighboring gene transfer RNA threonine (anticodon UGU) Neighboring gene fidgetin like 1 Neighboring gene IKAROS family zinc finger 1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037331.1 Chromosome 4 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Deduced amino acid sequence of bovine aromatic L-amino acid decarboxylase: homology to other decarboxylases. Kang UJ, et al. Brain Res Mol Brain Res, 1990 Jun. PMID 2166204
    2. Sequence evaluation of four pooled-tissue normalized bovine cDNA libraries and construction of a gene index for cattle. Smith TP, et al. Genome Res, 2001 Apr. PMID 11282978, Free PMC Article
    3. Characterization of 954 bovine full-CDS cDNA sequences. Harhay GP, et al. BMC Genomics, 2005 Nov 23. PMID 16305752, Free PMC Article
    4. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
    5. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables aromatic-L-amino-acid decarboxylase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables pyridoxal phosphate binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in amino acid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in catecholamine metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in serotonin biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    aromatic-L-amino-acid decarboxylase
    Names
    AADC
    dopa decarboxylase (aromatic L-amino acid decarboxylase)
    XP_024846170.1
    XP_024846171.1
    XP_024846172.1
    XP_024846174.1
    XP_059741356.1
    XP_059741358.1
    XP_059741359.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_173907.3 → NP_776332.2  aromatic-L-amino-acid decarboxylase

      Status: VALIDATED

      Source sequence(s)
      NKLS02000004
      UniProtKB/Swiss-Prot
      P27718, Q0V8S3

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037331.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      5335520..5441303
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_024990404.2 → XP_024846172.1  aromatic-L-amino-acid decarboxylase isoform X1

      UniProtKB/Swiss-Prot
      P27718, Q0V8S3
      UniProtKB/TrEMBL
      A5PJV5, F6R993
      Conserved Domains (1) summary
      pfam00282
      Location:35 → 414
      Pyridoxal_deC; Pyridoxal-dependent decarboxylase conserved domain

    2. XM_024990402.2 → XP_024846170.1  aromatic-L-amino-acid decarboxylase isoform X1

      UniProtKB/TrEMBL
      A5PJV5, F6R993
      Related
      ENSBTAP00000051814.3, ENSBTAT00000054605.3
      Conserved Domains (1) summary
      pfam00282
      Location:35 → 414
      Pyridoxal_deC; Pyridoxal-dependent decarboxylase conserved domain

    3. XM_024990406.2 → XP_024846174.1  aromatic-L-amino-acid decarboxylase isoform X2

      UniProtKB/Swiss-Prot
      P27718, Q0V8S3
      UniProtKB/TrEMBL
      A0AAA9TC53
      Related
      ENSBTAP00000093671.1, ENSBTAT00000097169.1
      Conserved Domains (1) summary
      pfam00282
      Location:35 → 376
      Pyridoxal_deC; Pyridoxal-dependent decarboxylase conserved domain

    4. XM_024990403.2 → XP_024846171.1  aromatic-L-amino-acid decarboxylase isoform X1

      UniProtKB/Swiss-Prot
      P27718, Q0V8S3
      UniProtKB/TrEMBL
      A5PJV5, F6R993
      Conserved Domains (1) summary
      pfam00282
      Location:35 → 414
      Pyridoxal_deC; Pyridoxal-dependent decarboxylase conserved domain

    5. XM_059885375.1 → XP_059741358.1  aromatic-L-amino-acid decarboxylase isoform X1

      UniProtKB/Swiss-Prot
      P27718, Q0V8S3
      UniProtKB/TrEMBL
      A5PJV5, F6R993

    6. XM_059885373.1 → XP_059741356.1  aromatic-L-amino-acid decarboxylase isoform X1

      UniProtKB/Swiss-Prot
      P27718, Q0V8S3
      UniProtKB/TrEMBL
      A5PJV5, F6R993

    7. XM_059885376.1 → XP_059741359.1  aromatic-L-amino-acid decarboxylase isoform X3

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P27718.2 GenPept UniProtKB/Swiss-Prot:P27718

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