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    pknox1.2 pbx/knotted 1 homeobox 1.2 [ Danio rerio (zebrafish) ]

    Gene ID: 170445, updated on 4-Jan-2025

    Summary

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    Official Symbol
    pknox1.2provided by ZNC
    Official Full Name
    pbx/knotted 1 homeobox 1.2provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-020123-1
    See related
    Ensembl:ENSDARG00000036542 AllianceGenome:ZFIN:ZDB-GENE-020123-1
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    pbx; knotted; prep1.2
    Summary
    Predicted to enable DNA binding activity. Acts upstream of or within pharyngeal system development and retinoic acid receptor signaling pathway. Predicted to be located in nucleus. Is expressed in brain; head; neural tube; and pectoral fin. Orthologous to human PKNOX1 (PBX/knotted 1 homeobox 1). [provided by Alliance of Genome Resources, Jan 2025]
    Orthologs
    all
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    Genomic context

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    See pknox1.2 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 1 NC_007112.7 (46960233..46984123, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 1 NC_007112.6 (46269001..46294636, complement)

    Chromosome 1 - NC_007112.7Genomic Context describing neighboring genes Neighboring gene pyridoxal (pyridoxine, vitamin B6) kinase b Neighboring gene transmembrane serine protease 3b Neighboring gene si:dkey-22n8.3 Neighboring gene intersectin 1 (SH3 domain protein)

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. prep1.2 and aldh1a2 participate to a positive loop required for branchial arches development in zebrafish. Vaccari E, et al. Dev Biol, 2010 Jul 1. PMID 20423710
    2. The Hox cofactors Meis1 and Pbx act upstream of gata1 to regulate primitive hematopoiesis. Pillay LM, et al. Dev Biol, 2010 Apr 15. PMID 20123093
    3. Pbx acts with Hand2 in early myocardial differentiation. Maves L, et al. Dev Biol, 2009 Sep 15. PMID 19607825, Free PMC Article
    4. Coordinate regulation of retinoic acid synthesis by pbx genes and fibroblast growth factor signaling by hoxb1b is required for hindbrain patterning and development. Selland LG, et al. Mech Dev, 2018 Apr. PMID 29496480
    5. Comprehensive expression map of transcription regulators in the adult zebrafish telencephalon reveals distinct neurogenic niches. Diotel N, et al. J Comp Neurol, 2015 Jun 1. PMID 25556858, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Loss of hoxb1b together with pbx4 reverts the hindbrain to a groundstate identity, demonstrating the importance of hox genes in patterning nearly the entire hindbrain, and a key requirement for Pbx in this process. Additionally, we provide evidence that while pbx genes regulate RA signaling, hoxb1b regulates hindbrain identity through complex regulation of FGF signaling
      Title: Coordinate regulation of retinoic acid synthesis by pbx genes and fibroblast growth factor signaling by hoxb1b is required for hindbrain patterning and development.
    2. prep1.2 participate to a positive loop required for branchial arches development in zebrafish
      Title: prep1.2 and aldh1a2 participate to a positive loop required for branchial arches development in zebrafish.
    3. The Hox cofactor pbx acts upstream of gata1 to regulate primitive hematopoiesis.
      Title: The Hox cofactors Meis1 and Pbx act upstream of gata1 to regulate primitive hematopoiesis.
    4. Pbx acts with Hand2 in early myocardial differentiation
      Title: Pbx acts with Hand2 in early myocardial differentiation.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in angiogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within pharyngeal system development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within retinoic acid receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    homeobox protein PKNOX1; pbx/knotted 1 homeobox 1.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007112.7 Reference GRCz11 Primary Assembly

      Range
      46960233..46984123 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_009294000.4 → XP_009292275.1  homeobox protein PKNOX1

      See identical proteins and their annotated locations for XP_009292275.1

      UniProtKB/TrEMBL
      A0A8N7TEV4, E7FBG0
      Related
      ENSDARP00000110278.1, ENSDART00000130607.3
      Conserved Domains (2) summary
      pfam05920
      Location:293 → 332
      Homeobox_KN; Homeobox KN domain
      pfam16493
      Location:91 → 175
      Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1

    2. XM_702776.8 → XP_707868.2  homeobox protein PKNOX1

      See identical proteins and their annotated locations for XP_707868.2

      UniProtKB/TrEMBL
      A0A8N7TEV4, E7FBG0
      Conserved Domains (2) summary
      pfam05920
      Location:293 → 332
      Homeobox_KN; Homeobox KN domain
      pfam16493
      Location:91 → 175
      Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1

    3. XM_068221694.1 → XP_068077795.1  homeobox protein PKNOX1

      UniProtKB/TrEMBL
      A0A8N7TEV4, E7FBG0

    4. XM_068221696.1 → XP_068077797.1  homeobox protein PKNOX1

      UniProtKB/TrEMBL
      A0A8N7TEV4, E7FBG0

    5. XM_068221695.1 → XP_068077796.1  homeobox protein PKNOX1

      UniProtKB/TrEMBL
      A0A8N7TEV4, E7FBG0

    6. XM_068221700.1 → XP_068077801.1  homeobox protein PKNOX1

      UniProtKB/TrEMBL
      A0A8N7TEV4, E7FBG0
    Nucleotide Protein Strain
    Heading Accession and Version

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