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    sytl4 synaptotagmin-like 4 [ Danio rerio (zebrafish) ]

    Gene ID: 553322, updated on 4-Jan-2025

    Summary

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    Official Symbol
    sytl4provided by ZNC
    Official Full Name
    synaptotagmin-like 4provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-070209-217
    See related
    Ensembl:ENSDARG00000102433 AllianceGenome:ZFIN:ZDB-GENE-070209-217
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    zgc:158411
    Summary
    Predicted to enable neurexin family protein binding activity. Predicted to be involved in exocytosis. Predicted to act upstream of or within intracellular protein transport. Predicted to be active in exocytic vesicle and plasma membrane. Orthologous to human SYTL4 (synaptotagmin like 4). [provided by Alliance of Genome Resources, Jan 2025]
    Orthologs
    human mouse all
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    Genomic context

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    See sytl4 in Genome Data Viewer
    Location:
    chromosome: 14
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 14 NC_007125.7 (35424540..35441429)
    105 previous assembly GRCz10 (GCF_000002035.5) 14 NC_007125.6 (35084315..35101111)

    Chromosome 14 - NC_007125.7Genomic Context describing neighboring genes Neighboring gene ribonuclease H2, subunit C Neighboring gene tRNA methyltransferase 12 homolog Neighboring gene sushi-repeat containing protein X-linked 2 Neighboring gene si:ch211-203d1.3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Modelling pancreatic β-cell inflammation in zebrafish identifies the natural product wedelolactone for human islet protection. Delgadillo-Silva LF, et al. Dis Model Mech, 2019 Jan 23. PMID 30679186, Free PMC Article
    2. Hematopoietic gene expression profile in zebrafish kidney marrow. Song HD, et al. Proc Natl Acad Sci U S A, 2004 Nov 16. PMID 15520368, Free PMC Article
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables neurexin family protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phospholipid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables small GTPase binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in exocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within intracellular protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in exocytic vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    synaptotagmin-like protein 4

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001080988.1 → NP_001074457.1  synaptotagmin-like protein 4

      See identical proteins and their annotated locations for NP_001074457.1

      Status: PROVISIONAL

      Source sequence(s)
      BC131873
      UniProtKB/TrEMBL
      A2RRV8
      Related
      ENSDARP00000132181.1, ENSDART00000162185.2
      Conserved Domains (3) summary
      cd04020
      Location:512 → 682
      C2B_SLP_1-2-3-4; C2 domain second repeat present in Synaptotagmin-like proteins 1-4
      cd04029
      Location:375 → 496
      C2A_SLP-4_5; C2 domain first repeat present in Synaptotagmin-like proteins 4 and 5
      cd15764
      Location:60 → 109
      FYVE_Slp4; FYVE-related domain found in synaptotagmin-like protein 4 (Slp4) and similar proteins

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007125.7 Reference GRCz11 Primary Assembly

      Range
      35424540..35441429
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_021481021.2 → XP_021336696.1  synaptotagmin-like protein 4 isoform X1

      UniProtKB/TrEMBL
      A0A8M9QP53, F1QIG1
      Conserved Domains (4) summary
      cd04020
      Location:512 → 682
      C2B_SLP_1-2-3-4; C2 domain second repeat present in Synaptotagmin-like proteins 1-4
      cd04029
      Location:375 → 496
      C2A_SLP-4_5; C2 domain first repeat present in Synaptotagmin-like proteins 4 and 5
      cd15764
      Location:60 → 109
      FYVE_Slp4; FYVE-related domain found in synaptotagmin-like protein 4 (Slp4) and similar proteins
      cl22851
      Location:10 → 124
      PHD_SF; PHD finger superfamily

    2. XM_021481020.2 → XP_021336695.1  synaptotagmin-like protein 4 isoform X1

      UniProtKB/TrEMBL
      A0A8M9QP53, F1QIG1
      Conserved Domains (4) summary
      cd04020
      Location:512 → 682
      C2B_SLP_1-2-3-4; C2 domain second repeat present in Synaptotagmin-like proteins 1-4
      cd04029
      Location:375 → 496
      C2A_SLP-4_5; C2 domain first repeat present in Synaptotagmin-like proteins 4 and 5
      cd15764
      Location:60 → 109
      FYVE_Slp4; FYVE-related domain found in synaptotagmin-like protein 4 (Slp4) and similar proteins
      cl22851
      Location:10 → 124
      PHD_SF; PHD finger superfamily

    3. XM_009291117.4 → XP_009289392.1  synaptotagmin-like protein 4 isoform X1

      UniProtKB/TrEMBL
      A0A8M9QP53, F1QIG1
      Conserved Domains (4) summary
      cd04020
      Location:512 → 682
      C2B_SLP_1-2-3-4; C2 domain second repeat present in Synaptotagmin-like proteins 1-4
      cd04029
      Location:375 → 496
      C2A_SLP-4_5; C2 domain first repeat present in Synaptotagmin-like proteins 4 and 5
      cd15764
      Location:60 → 109
      FYVE_Slp4; FYVE-related domain found in synaptotagmin-like protein 4 (Slp4) and similar proteins
      cl22851
      Location:10 → 124
      PHD_SF; PHD finger superfamily
    Nucleotide Protein Strain
    Heading Accession and Version

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