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    Lrig1 leucine-rich repeats and immunoglobulin-like domains 1 [ Mus musculus (house mouse) ]

    Gene ID: 16206, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Lrig1provided by MGI
    Official Full Name
    leucine-rich repeats and immunoglobulin-like domains 1provided by MGI
    Primary source
    MGI:MGI:107935
    See related
    Ensembl:ENSMUSG00000030029 AllianceGenome:MGI:107935
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Img; LIG-1; D6Bwg0781e
    Summary
    Acts upstream of or within several processes, including innervation; otolith morphogenesis; and sensory perception of sound. Predicted to be located in plasma membrane. Predicted to be active in extracellular matrix and extracellular space. Is expressed in several structures, including alimentary system; central nervous system; heart; integumental system; and sensory organ. Orthologous to human LRIG1 (leucine rich repeats and immunoglobulin like domains 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in colon adult (RPKM 30.2), cerebellum adult (RPKM 20.8) and 26 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Lrig1 in Genome Data Viewer
    Location:
    6 D2; 6 43.15 cM
    Exon count:
    25
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (94581510..94677205, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (94604529..94700298, complement)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene ubiquitin-conjugating enzyme E2 variant 1 pseudogene Neighboring gene STARR-seq mESC enhancer starr_16710 Neighboring gene solute carrier family 25 (mitochondrial carrier, phosphate carrier), member 26 Neighboring gene proteasome (prosome, macropain) subunit, alpha type 3 pseudogene Neighboring gene STARR-seq mESC enhancer starr_16711 Neighboring gene microRNA 7041 Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:94587371-94587480 Neighboring gene VISTA enhancer mm1736 Neighboring gene STARR-seq mESC enhancer starr_16724 Neighboring gene VISTA enhancer mm878 Neighboring gene prefoldin 4 pseudogene Neighboring gene STARR-seq mESC enhancer starr_16726 Neighboring gene STARR-seq mESC enhancer starr_16728 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. LRIG1 is a gatekeeper to exit from quiescence in adult neural stem cells. Marqués-Torrejón MÁ, et al. Nat Commun, 2021 May 10. PMID 33972529, Free PMC Article
    2. LRIG1 expression during homeostasis and skin wound healing in mice. Murad S, et al. J Biol Regul Homeost Agents, 2015 Oct-Dec. PMID 26753643
    3. Lrig1 is a haploinsufficient tumor suppressor gene in malignant glioma. Mao F, et al. Oncogenesis, 2018 Feb 2. PMID 29391393, Free PMC Article
    4. Epidermal overexpression of LRIG1 disturbs development and homeostasis in skin by disrupting the ERBB system. Hoesl C, et al. J Dermatol Sci, 2019 Dec. PMID 31796338
    5. LRIG1 is a triple threat: ERBB negative regulator, intestinal stem cell marker and tumour suppressor. Wang Y, et al. Br J Cancer, 2013 May 14. PMID 23558895, Free PMC Article

    See all (126) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Lrig1 regulates cell fate specification of glutamatergic neurons via FGF-driven Jak2/Stat3 signaling in cortical progenitors.
      Title: Lrig1 regulates cell fate specification of glutamatergic neurons via FGF-driven Jak2/Stat3 signaling in cortical progenitors.
    2. LRIG1 engages ligand VISTA and impairs tumor-specific CD8[+] T cell responses.
      Title: LRIG1 engages ligand VISTA and impairs tumor-specific CD8(+) T cell responses.
    3. Lrig1 drives cryptogenesis and restrains proliferation during colon development.
      Title: Lrig1 drives cryptogenesis and restrains proliferation during colon development.
    4. Lrig1-expression confers suppressive function to CD4[+] cells and is essential for averting autoimmunity via the Smad2/3/Foxp3 axis.
      Title: Lrig1-expression confers suppressive function to CD4(+) cells and is essential for averting autoimmunity via the Smad2/3/Foxp3 axis.
    5. Lrig1 expression identifies quiescent stem cells in the ventricular-subventricular zone from postnatal development to adulthood and limits their persistent hyperproliferation.
      Title: Lrig1 expression identifies quiescent stem cells in the ventricular-subventricular zone from postnatal development to adulthood and limits their persistent hyperproliferation.
    6. Lrig1- and Wnt-dependent niches dictate segregation of resident immune cells and melanocytes in murine tail epidermis.
      Title: Lrig1- and Wnt-dependent niches dictate segregation of resident immune cells and melanocytes in murine tail epidermis.
    7. Cell-Autonomous Role of EGFR in Spontaneous Duodenal Tumors in LRIG1 Null Mice.
      Title: Cell-Autonomous Role of EGFR in Spontaneous Duodenal Tumors in LRIG1 Null Mice.
    8. Lrig1 and Lrig3 cooperate to control Ret receptor signaling, sensory axonal growth and epidermal innervation.
      Title: Lrig1 and Lrig3 cooperate to control Ret receptor signaling, sensory axonal growth and epidermal innervation.
    9. LRIG1-Mediated Inhibition of EGF Receptor Signaling Regulates Neural Precursor Cell Proliferation in the Neocortex.
      Title: LRIG1-Mediated Inhibition of EGF Receptor Signaling Regulates Neural Precursor Cell Proliferation in the Neocortex.
    10. Lrig1 expression prospectively identifies stem cells in the ventricular-subventricular zone that are neurogenic throughout adult life.
      Title: Lrig1 expression prospectively identifies stem cells in the ventricular-subventricular zone that are neurogenic throughout adult life.
    Submit: New GeneRIF Correction See all GeneRIFs (32)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Chemically induced (ENU) (1) 
    • Endonuclease-mediated (2) 
    • Gene trapped (1)  1 citation
    • Targeted (10)  1 citation

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    acts_upstream_of_or_within hair cycle process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within innervation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within otolith morphogenesis IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within sensory perception of sound IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in extracellular matrix IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    leucine-rich repeats and immunoglobulin-like domains protein 1
    Names
    integral membrane glycoprotein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001355269.2 → NP_001342198.1  leucine-rich repeats and immunoglobulin-like domains protein 1 isoform 2 precursor

      Status: VALIDATED

      Source sequence(s)
      AC122272, AC155330
      UniProtKB/TrEMBL
      B7ZP45
      Conserved Domains (7) summary
      cd05763
      Location:618 → 692
      Ig_1; Subgroup of the immunoglobulin (Ig) superfamily
      smart00082
      Location:444 → 492
      LRRCT; Leucine rich repeat C-terminal domain
      COG4886
      Location:78 → 330
      LRR; Leucine-rich repeat (LRR) protein [Transcription]
      pfam07679
      Location:695 → 782
      I-set; Immunoglobulin I-set domain
      sd00033
      Location:143 → 166
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:385 → 441
      LRR_8; Leucine rich repeat
      pfam13927
      Location:496 → 583
      Ig_3; Immunoglobulin domain

    2. NM_001410069.1 → NP_001396998.1  leucine-rich repeats and immunoglobulin-like domains protein 1 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC122272, AC155330

    3. NM_001410070.1 → NP_001396999.1  leucine-rich repeats and immunoglobulin-like domains protein 1 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC122272, AC155330

    4. NM_008377.3 → NP_032403.2  leucine-rich repeats and immunoglobulin-like domains protein 1 isoform 1 precursor

      See identical proteins and their annotated locations for NP_032403.2

      Status: VALIDATED

      Source sequence(s)
      AC122272, AC155330
      Consensus CDS
      CCDS20380.1
      UniProtKB/Swiss-Prot
      E9QL89, P70193
      UniProtKB/TrEMBL
      B7ZP45
      Related
      ENSMUSP00000098686.3, ENSMUST00000101126.3
      Conserved Domains (8) summary
      cd05763
      Location:618 → 692
      Ig_1; Subgroup of the immunoglobulin (Ig) superfamily
      smart00408
      Location:709 → 772
      IGc2; Immunoglobulin C-2 Type
      smart00082
      Location:444 → 492
      LRRCT; Leucine rich repeat C-terminal domain
      cd00116
      Location:57 → 325
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      pfam07679
      Location:601 → 691
      I-set; Immunoglobulin I-set domain
      sd00033
      Location:143 → 166
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:213 → 273
      LRR_8; Leucine rich repeat
      pfam13927
      Location:496 → 583
      Ig_3; Immunoglobulin domain

    RNA

    1. NR_176936.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC122272, AC155330

    2. NR_176937.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC122272, AC155330

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      94581510..94677205 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030255196.2 → XP_030111056.1  leucine-rich repeats and immunoglobulin-like domains protein 1 isoform X2

      Conserved Domains (6) summary
      cd05763
      Location:356 → 430
      Ig_1; Subgroup of the immunoglobulin (Ig) superfamily
      smart00082
      Location:182 → 230
      LRRCT; Leucine rich repeat C-terminal domain
      sd00033
      Location:3 → 24
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:123 → 179
      LRR_8; Leucine rich repeat
      pfam07679
      Location:433 → 520
      I-set; Immunoglobulin I-set domain
      cl11960
      Location:235 → 335
      Ig; Immunoglobulin domain

    2. XM_030255198.1 → XP_030111058.1  leucine-rich repeats and immunoglobulin-like domains protein 1 isoform X2

      Conserved Domains (6) summary
      cd05763
      Location:356 → 430
      Ig_1; Subgroup of the immunoglobulin (Ig) superfamily
      smart00082
      Location:182 → 230
      LRRCT; Leucine rich repeat C-terminal domain
      sd00033
      Location:3 → 24
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:123 → 179
      LRR_8; Leucine rich repeat
      pfam07679
      Location:433 → 520
      I-set; Immunoglobulin I-set domain
      cl11960
      Location:235 → 335
      Ig; Immunoglobulin domain

    3. XM_036165882.1 → XP_036021775.1  leucine-rich repeats and immunoglobulin-like domains protein 1 isoform X1

      UniProtKB/TrEMBL
      B7ZP45
      Conserved Domains (7) summary
      smart00082
      Location:339 → 387
      LRRCT; Leucine rich repeat C-terminal domain
      sd00033
      Location:38 → 61
      LRR_RI; leucine-rich repeat [structural motif]
      pfam07679
      Location:590 → 677
      I-set; Immunoglobulin I-set domain
      pfam13927
      Location:391 → 478
      Ig_3; Immunoglobulin domain
      cd00096
      Location:598 → 601
      Ig; Ig strand A' [structural motif]
      cd05763
      Location:497 → 587
      IgI_LRIG1-like; Immunoglobulin (Ig)-like ectodomain of the LRIG1 (Leucine-rich Repeats And Immunoglobulin-like Domains Protein 1) and similar proteins; member of the I-set of IgSF domains
      cd21340
      Location:20 → 220
      PPP1R42; protein phosphatase 1 regulatory subunit 42

    4. XM_030255197.1 → XP_030111057.1  leucine-rich repeats and immunoglobulin-like domains protein 1 isoform X2

      Conserved Domains (6) summary
      cd05763
      Location:356 → 430
      Ig_1; Subgroup of the immunoglobulin (Ig) superfamily
      smart00082
      Location:182 → 230
      LRRCT; Leucine rich repeat C-terminal domain
      sd00033
      Location:3 → 24
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:123 → 179
      LRR_8; Leucine rich repeat
      pfam07679
      Location:433 → 520
      I-set; Immunoglobulin I-set domain
      cl11960
      Location:235 → 335
      Ig; Immunoglobulin domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P70193.2 GenPept UniProtKB/Swiss-Prot:P70193

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