Cbx3 chromobox 3 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Cbx3provided by MGI
Official Full Name: chromobox 3provided by MGI
Primary source: MGI:MGI:108515
See related: Ensembl:ENSMUSG00000029836 AllianceGenome:MGI:108515
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: M32; HP1g
Summary: Enables DNA-binding transcription factor binding activity and transcription cis-regulatory region binding activity. Acts upstream of or within negative regulation of DNA-templated transcription. Located in chromocenter; chromosome, centromeric region; and nuclear envelope. Is expressed in several structures, including central nervous system; embryo ectoderm; gonad; gut; and retina nuclear layer. Orthologous to human CBX3 (chromobox 3). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in CNS E11.5 (RPKM 59.6), CNS E14 (RPKM 32.1) and 12 other tissues See more
Orthologs: human all
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Genomic context

Location:: 6 B3; 6 24.89 cM

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	6	NC_000072.7 (51447596..51460684)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	6	NC_000072.6 (51470154..51483704)

Chromosome 6 - NC_000072.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Mouse HP1gamma regulates TRF1 expression and telomere stability.
Title: Mouse HP1γ regulates TRF1 expression and telomere stability.
Targeting Cbx3/HP1gamma Induces LEF-1 and IL-21R to Promote Tumor-Infiltrating CD8 T-Cell Persistence.
Title: Targeting Cbx3/HP1γ Induces LEF-1 and IL-21R to Promote Tumor-Infiltrating CD8 T-Cell Persistence.
these results describe the regulation and participation of HP1gamma in a novel membrane-to-nucleus pathway, through NGF-PKA signaling.
Title: Mechanisms Underlying the Regulation of HP1γ by the NGF-PKA Signaling Pathway.
Cbx3 modulates vascular smooth muscle cells contractile and collagen gene expression, as well as VSMC proliferation, migration, and apoptosis via a Notch3 pathway, and plays an important role in controlling injury-induced neointima formation.
Title: Cbx3 inhibits vascular smooth muscle cell proliferation, migration, and neointima formation.
Citrullination of HP1gamma is dynamically regulated during mESC differentiation. The citrullinated residues lie within the HP1gamma chromodomain and are important for H3K9me3 binding.
Title: Citrullination of HP1γ chromodomain affects association with chromatin.
Data indicate that HP1gamma is dispensable for cell cycle exit and normal cardiac growth but has a significant role in maintaining H4K20me3 and regulating a limited number of genes in cardiac myocytes.
Title: Deletion of HP1γ in cardiac myocytes affects H4K20me3 levels but does not impact cardiac growth.
HP1gamma is present in the nucleus and the cytoplasm interacting with actin, a protein complex that may exert different functions depending on its subcellular localization.
Title: Heterochromatin protein (HP)1γ is not only in the nucleus but also in the cytoplasm interacting with actin in both cell compartments.
it is the small size of the Cbx3hypo/hypo neonates, a likely consequence of placental growth and transport defects, combined with a possible inability to thermoregulate that causes the severe postnatal mortality.
Title: A hypomorphic Cbx3 allele causes prenatal growth restriction and perinatal energy homeostasis defects.
Forced expression of HP1gamma facilitated axonal and dendritic development, suggesting that the increase of HP1gamma is a rate limiting step in neuronal maturation.
Title: Up-regulation of HP1γ expression during neuronal maturation promotes axonal and dendritic development in mouse embryonic neocortex.
in addition to histones, bacteria control host transcription by modulating the activity of HP1 proteins, with potential implications in transcriptional reprogramming at the mucosal barrier.
Title: Shigella flexneri targets the HP1γ subcode through the phosphothreonine lyase OspF.

Submit: New GeneRIF Correction See all GeneRIFs (19)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (4)
Gene trapped (1) 1 citation
Targeted (5) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

UniSTS:238126 (e-PCR)
- UniSTS:238126

Cbx3 (e-PCR), detects polymorphism
- UniSTS:238126

Cbx3 (e-PCR), detects polymorphism
- UniSTS:239186

BB463959 (e-PCR)
- UniSTS:207955

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA-binding transcription factor binding	IPI Inferred from Physical Interaction more info	PubMed
enables chromatin binding	IBA Inferred from Biological aspect of Ancestor more info
enables enzyme binding	ISO Inferred from Sequence Orthology more info
enables histone methyltransferase binding	ISO Inferred from Sequence Orthology more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables methylated histone binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein domain specific binding	ISO Inferred from Sequence Orthology more info
enables transcription cis-regulatory region binding	IDA Inferred from Direct Assay more info	PubMed
enables transcription coregulator binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in DNA damage response	ISO Inferred from Sequence Orthology more info
involved_in DNA damage response	ISS Inferred from Sequence or Structural Similarity more info
involved_in heterochromatin formation	IBA Inferred from Biological aspect of Ancestor more info
involved_in heterochromatin formation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in rhythmic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of RNA polymerase II transcription regulator complex	ISO Inferred from Sequence Orthology more info
located_in chromatin	IDA Inferred from Direct Assay more info	PubMed
located_in chromatin	ISO Inferred from Sequence Orthology more info
part_of chromatin lock complex	ISO Inferred from Sequence Orthology more info
located_in chromocenter	IDA Inferred from Direct Assay more info	PubMed
located_in chromosome, centromeric region	ISO Inferred from Sequence Orthology more info
located_in condensed chromosome, centromeric region	IDA Inferred from Direct Assay more info	PubMed
located_in euchromatin	ISO Inferred from Sequence Orthology more info
located_in heterochromatin	IDA Inferred from Direct Assay more info	PubMed
located_in heterochromatin	ISO Inferred from Sequence Orthology more info
located_in nuclear envelope	IDA Inferred from Direct Assay more info	PubMed
located_in nucleoplasm	TAS Traceable Author Statement more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in pericentric heterochromatin	IBA Inferred from Biological aspect of Ancestor more info
located_in pericentric heterochromatin	IDA Inferred from Direct Assay more info	PubMed
located_in senescence-associated heterochromatin focus	ISO Inferred from Sequence Orthology more info
located_in site of DNA damage	ISO Inferred from Sequence Orthology more info
located_in site of DNA damage	ISS Inferred from Sequence or Structural Similarity more info
located_in spindle	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: chromobox protein homolog 3

Names: HP1 gamma; heterochromatin protein 1 gamma; heterochromatin protein 1 homolog gamma; modifier 2 protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001355002.1 → NP_001341931.1 chromobox protein homolog 3

Status: VALIDATED

Source sequence(s)

AC153877, AC154011

Consensus CDS

CCDS20135.1

UniProtKB/Swiss-Prot

P23198, Q921C4

UniProtKB/TrEMBL

Q32P00, Q9DCC5

Conserved Domains (2) summary

cd18652
Location:29 → 78

CD_HP1gamma_Cbx3; chromodomain of heterochromatin protein 1 homolog gamma

cd18656
Location:116 → 173

CSD_HP1gamma_Cbx3; chromo shadow domain of heterochromatin protein 1 gamma homolog gamma
NM_007624.4 → NP_031650.3 chromobox protein homolog 3

See identical proteins and their annotated locations for NP_031650.3

Status: VALIDATED

Source sequence(s)

AK002910, AK083957, BC059831, CJ093936

Consensus CDS

CCDS20135.1

UniProtKB/Swiss-Prot

P23198, Q921C4

UniProtKB/TrEMBL

Q32P00, Q9DCC5

Related

ENSMUSP00000031862.8, ENSMUST00000031862.14

Conserved Domains (2) summary

cd18652
Location:29 → 78

CD_HP1gamma_Cbx3; chromodomain of heterochromatin protein 1 homolog gamma

cd18656
Location:116 → 173

CSD_HP1gamma_Cbx3; chromo shadow domain of heterochromatin protein 1 gamma homolog gamma

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000072.7 Reference GRCm39 C57BL/6J

Range

51447596..51460684

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_001037798.1: Suppressed sequence

Description

NM_001037798.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript.