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    APC APC regulator of WNT signaling pathway [ Homo sapiens (human) ]

    Gene ID: 324, updated on 10-Dec-2024

    Summary

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    Official Symbol
    APCprovided by HGNC
    Official Full Name
    APC regulator of WNT signaling pathwayprovided by HGNC
    Primary source
    HGNC:HGNC:583
    See related
    Ensembl:ENSG00000134982 MIM:611731; AllianceGenome:HGNC:583
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    GS; DP2; DP3; BTPS2; DESMD; DP2.5; PPP1R46
    Summary
    This gene encodes a tumor suppressor protein that acts as an antagonist of the Wnt signaling pathway. It is also involved in other processes including cell migration and adhesion, transcriptional activation, and apoptosis. Defects in this gene cause familial adenomatous polyposis (FAP), an autosomal dominant pre-malignant disease that usually progresses to malignancy. Mutations in the APC gene have been found to occur in most colorectal cancers, where disease-associated mutations tend to be clustered in a small region designated the mutation cluster region (MCR) and result in a truncated protein product. [provided by RefSeq, Jun 2022]
    Annotation information
    Note: PROC (Gene ID: 5624) and APC (Gene ID: 324) loci share the APC symbol/alias in common. [08 Feb 2019]
    Expression
    Ubiquitous expression in brain (RPKM 25.7), colon (RPKM 4.5) and 23 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See APC in Genome Data Viewer
    Location:
    5q22.2
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (112707498..112846239)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (113218062..113356772)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (112043195..112181936)

    Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 2200 Neighboring gene uncharacterized LOC102467216 Neighboring gene Sharpr-MPRA regulatory region 7502 Neighboring gene Sharpr-MPRA regulatory region 14787 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22910 Neighboring gene RNA, U6 small nuclear 482, pseudogene Neighboring gene CBX3 pseudogene 3 Neighboring gene Sharpr-MPRA regulatory region 9882 Neighboring gene signal recognition particle 19 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr5:112226954-112228153 Neighboring gene receptor accessory protein 5 Neighboring gene X-box binding protein 1 pseudogene 1 Neighboring gene ZRSR2 pseudogene 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. [Analysis of C.3925_3929 deletional mutations of APC gene in pedigrees with familial adenomatous polyposis]. Chen Q, et al. Zhonghua Yi Xue Yi Chuan Xue Za Zhi, 2015 Aug. PMID 26252100
    2. High-resolution melting (HRM) re-analysis of a polyposis patients cohort reveals previously undetected heterozygous and mosaic APC gene mutations. Out AA, et al. Fam Cancer, 2015 Jun. PMID 25604157, Free PMC Article
    3. [Effect of Hydralazine on demethylation status and expression of APC gene, proliferation and apoptosis of human cervical cancer cell lines]. Song YH, et al. Zhonghua Bing Li Xue Za Zhi, 2007 Sep. PMID 18070451
    4. A novel APC mutation defines a second locus for Cenani-Lenz syndrome. Patel N, et al. J Med Genet, 2015 May. PMID 25676610
    5. Meningiomas exhibit loss of heterozygosity of the APC gene. Pećina-Slaus N, et al. J Neurooncol, 2008 Mar. PMID 18066497

    See all (1012) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. APC and ZBTB2 May Mediate M2 Macrophage Infiltration to Promote the Development of Renal Fibrosis: A Bioinformatics Analysis.
      Title: APC and ZBTB2 May Mediate M2 Macrophage Infiltration to Promote the Development of Renal Fibrosis: A Bioinformatics Analysis.
    2. Plasma-Derived Extracellular Vesicles and Non-Extracellular Vesicle Components from APC[Min/+] Mice Promote Pro-Tumorigenic Activities and Activate Human Colonic Fibroblasts via the NF-kappaB Signaling Pathway.
      Title: Plasma-Derived Extracellular Vesicles and Non-Extracellular Vesicle Components from APC(Min/+) Mice Promote Pro-Tumorigenic Activities and Activate Human Colonic Fibroblasts via the NF-κB Signaling Pathway.
    3. Bcl-2 Up-Regulation Mediates Taxane Resistance Downstream of APC Loss.
      Title: Bcl-2 Up-Regulation Mediates Taxane Resistance Downstream of APC Loss.
    4. Mutational analysis of pulmonary large cell neuroendocrine carcinoma: APC gene mutations identify a good prognostic factor.
      Title: Mutational analysis of pulmonary large cell neuroendocrine carcinoma: APC gene mutations identify a good prognostic factor.
    5. BET protein-dependent E2F pathway activity confers bell-shaped type resistance to tankyrase inhibitors in APC-mutated colorectal cancer.
      Title: BET protein-dependent E2F pathway activity confers bell-shaped type resistance to tankyrase inhibitors in APC-mutated colorectal cancer.
    6. beta-catenin mediates growth defects induced by centrosome loss in a subset of APC mutant colorectal cancer independently of p53.
      Title: β-catenin mediates growth defects induced by centrosome loss in a subset of APC mutant colorectal cancer independently of p53.
    7. Case Series of Men with the Germline APC I1307K variant and Treatment-Emergent Neuroendocrine Prostate Cancer.
      Title: Case Series of Men with the Germline APC I1307K variant and Treatment-Emergent Neuroendocrine Prostate Cancer.
    8. Clinical features and distribution of the APC variant in duodenal and ampullary polyps in patients with familial adenomatous polyposis: a multicenter retrospective cohort study in Japan.
      Title: Clinical features and distribution of the APC variant in duodenal and ampullary polyps in patients with familial adenomatous polyposis: a multicenter retrospective cohort study in Japan.
    9. A novel APC mutation associated with Gardner syndrome in a Chinese family.
      Title: A novel APC mutation associated with Gardner syndrome in a Chinese family.
    10. APC mutations disrupt beta-catenin destruction complex condensates organized by Axin phase separation.
      Title: APC mutations disrupt β-catenin destruction complex condensates organized by Axin phase separation.
    Submit: New GeneRIF Correction See all GeneRIFs (691)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Professional guidelines

    Description
    Professional guideline
    ACMG 2013

    The ACMG recommends that laboratories performing clinical sequencing seek and report mutations in APC that are pathogenic or expected to be pathogenic.

    GuidelinePubMed

    Associated conditions

    Description Tests
    Colorectal cancer
    MedGen: C0346629 OMIM: 114500 GeneReviews: Lynch Syndrome
    		Compare labs
    Desmoid disease, hereditary
    MedGen: C1851124 OMIM: 135290 GeneReviews: APC-Associated Polyposis Conditions
    		Compare labs
    Familial adenomatous polyposis 1
    MedGen: C2713442 OMIM: 175100 GeneReviews: APC-Associated Polyposis Conditions
    		Compare labs
    Familial multiple polyposis syndrome
    MedGen: C0032580 GeneReviews: Not available
    		Compare labs
    Gastric adenocarcinoma and proximal polyposis of the stomach
    MedGen: C4749917 OMIM: 619182 GeneReviews: APC-Associated Polyposis Conditions
    		Compare labs
    Gastric cancer
    MedGen: C0024623 OMIM: 613659 GeneReviews: Not available
    		Compare labs
    Hepatocellular carcinoma
    MedGen: C2239176 OMIM: 114550 GeneReviews: Not available
    		Compare labs

    Copy number response

    Description
    Copy number response
    Triplosensitivity

    No evidence available (Last evaluated 2021-07-18)

    ClinGen Genome Curation Page
    Haploinsufficency

    Sufficient evidence for dosage pathogenicity (Last evaluated 2021-07-18)

    ClinGen Genome Curation PagePubMed

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Potential readthrough

    Included gene: SRP19

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables beta-catenin binding EXP
    Inferred from Experiment
    more info
    		 PubMed 
    enables beta-catenin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables beta-catenin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables beta-catenin binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    NOT enables cadherin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables dynein complex binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables gamma-catenin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables gamma-catenin binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables microtubule binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables microtubule binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables microtubule plus-end binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein kinase binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein kinase binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein kinase regulator activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables ubiquitin protein ligase binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in DNA damage response IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in Wnt signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in bicellular tight junction assembly NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in cell adhesion NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in cell fate specification IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell migration IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell migration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in endocardial cushion morphogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in heart valve development ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in insulin receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within mitotic cytokinesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within mitotic spindle assembly checkpoint signaling IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of G1/S transition of mitotic cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of canonical Wnt signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of canonical Wnt signaling pathway IC
    Inferred by Curator
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of canonical Wnt signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in negative regulation of canonical Wnt signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in negative regulation of canonical Wnt signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of canonical Wnt signaling pathway NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in negative regulation of cell cycle G1/S phase transition IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of cell population proliferation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of cyclin-dependent protein serine/threonine kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of microtubule depolymerization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of microtubule depolymerization IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of microtubule depolymerization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in nervous system development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in pattern specification process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within positive regulation of apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of cell migration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of cold-induced thermogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in positive regulation of protein catabolic process IC
    Inferred by Curator
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of protein catabolic process IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in positive regulation of protein localization to centrosome IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of pseudopodium assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in protein-containing complex assembly IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of attachment of spindle microtubules to kinetochore IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of attachment of spindle microtubules to kinetochore NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in regulation of microtubule-based movement IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in regulation of microtubule-based process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    		  
    part_of Wnt signalosome NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    colocalizes_with adherens junction IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of beta-catenin destruction complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of beta-catenin destruction complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of beta-catenin destruction complex NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    located_in bicellular tight junction IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of catenin complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of catenin complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in centrosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    colocalizes_with cytoplasmic microtubule IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  
    located_in kinetochore IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in lamellipodium IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in lateral plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    colocalizes_with microtubule IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in perinuclear region of cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    colocalizes_with plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in ruffle membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    adenomatous polyposis coli protein
    Names
    APC, WNT signaling pathway regulator
    WNT signaling pathway regulator
    adenomatosis polyposis coli tumor suppressor
    adenomatous polyposis coli (APC)
    deleted in polyposis 2.5
    epididymis secretory sperm binding protein
    protein phosphatase 1, regulatory subunit 46

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_008481.4 RefSeqGene

      Range
      19985..158719
      Download
      GenBank, FASTA, Sequence Viewer (Graphics), LRG_130

    mRNA and Protein(s)

    1. NM_000038.6 → NP_000029.2  adenomatous polyposis coli protein isoform b

      See identical proteins and their annotated locations for NP_000029.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. This variant also contains an alternate in-frame exon compared to variant 1. The encoded isoform (b) has a distinct N-terminus and is longer than isoform a. Variants 2, 3, and 4 all encode the same isoform (b).
      Source sequence(s)
      AB210001, CA313732, DA795663, M73548
      Consensus CDS
      CCDS4107.1
      UniProtKB/Swiss-Prot
      B7Z2B6, D3DT03, P25054, Q15162, Q15163, Q93042
      UniProtKB/TrEMBL
      A0A224ANK2
      Related
      ENSP00000257430.4, ENST00000257430.9
      Conserved Domains (17) summary
      smart00185
      Location:649 → 689
      ARM; Armadillo/beta-catenin-like repeats
      pfam16689
      Location:4 → 55
      APC_N_CC; Coiled-coil N-terminus of APC, dimerisation domain
      sd00043
      Location:465 → 508
      ARM; armadillo repeat [structural motif]
      pfam05923
      Location:1637 → 1660
      APC_r; APC repeat
      pfam05924
      Location:2033 → 2052
      SAMP; SAMP Motif
      pfam05937
      Location:2670 → 2843
      EB1_binding; EB-1 Binding Domain
      pfam05956
      Location:2223 → 2568
      APC_basic; APC basic domain
      pfam11414
      Location:127 → 207
      Suppressor_APC; Adenomatous polyposis coli tumor suppressor protein
      pfam16629
      Location:732 → 1018
      Arm_APC_u3; Armadillo-associated region on APC
      pfam16630
      Location:1036 → 1135
      APC_u5; Unstructured region on APC between 1st and 2nd catenin-bdg motifs
      pfam16633
      Location:1283 → 1368
      APC_u9; Unstructured region on APC between 1st two creatine-rich regions
      pfam16634
      Location:1662 → 1715
      APC_u13; Unstructured region on APC between APC_crr and SAMP
      pfam16635
      Location:1746 → 1839
      APC_u14; Unstructured region on APC between SAMP and APC_crr
      pfam16636
      Location:1873 → 1947
      APC_u15; Unstructured region on APC between APC_crr regions 5 and 6
      cl21727
      Location:533 → 734
      VATPase_H; VATPase_H, regulatory vacuolar ATP synthase subunit H (Vma13p); activation component of the peripheral V1 complex of V-ATPase, a heteromultimeric enzyme which uses ATP to actively transport protons into organelles and extracellular compartments. The ...
      cl25732
      Location:4 → 272
      SMC_N; RecF/RecN/SMC N terminal domain
      cl25751
      Location:1291 → 1701
      DUF4045; Domain of unknown function (DUF4045)

    2. NM_001127510.3 → NP_001120982.1  adenomatous polyposis coli protein isoform b

      See identical proteins and their annotated locations for NP_001120982.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. This variant also contains an alternate in-frame exon compared to variant 1. The encoded isoform (b) has a distinct N-terminus and is longer than isoform a. Variants 2, 3, and 4 all encode the same isoform (b).
      Source sequence(s)
      AB210001, CA313732, DA795663
      Consensus CDS
      CCDS4107.1
      UniProtKB/Swiss-Prot
      B7Z2B6, D3DT03, P25054, Q15162, Q15163, Q93042
      UniProtKB/TrEMBL
      A0A224ANK2
      Related
      ENSP00000427089.2, ENST00000508376.6
      Conserved Domains (17) summary
      smart00185
      Location:649 → 689
      ARM; Armadillo/beta-catenin-like repeats
      pfam16689
      Location:4 → 55
      APC_N_CC; Coiled-coil N-terminus of APC, dimerisation domain
      sd00043
      Location:465 → 508
      ARM; armadillo repeat [structural motif]
      pfam05923
      Location:1637 → 1660
      APC_r; APC repeat
      pfam05924
      Location:2033 → 2052
      SAMP; SAMP Motif
      pfam05937
      Location:2670 → 2843
      EB1_binding; EB-1 Binding Domain
      pfam05956
      Location:2223 → 2568
      APC_basic; APC basic domain
      pfam11414
      Location:127 → 207
      Suppressor_APC; Adenomatous polyposis coli tumor suppressor protein
      pfam16629
      Location:732 → 1018
      Arm_APC_u3; Armadillo-associated region on APC
      pfam16630
      Location:1036 → 1135
      APC_u5; Unstructured region on APC between 1st and 2nd catenin-bdg motifs
      pfam16633
      Location:1283 → 1368
      APC_u9; Unstructured region on APC between 1st two creatine-rich regions
      pfam16634
      Location:1662 → 1715
      APC_u13; Unstructured region on APC between APC_crr and SAMP
      pfam16635
      Location:1746 → 1839
      APC_u14; Unstructured region on APC between SAMP and APC_crr
      pfam16636
      Location:1873 → 1947
      APC_u15; Unstructured region on APC between APC_crr regions 5 and 6
      cl21727
      Location:533 → 734
      VATPase_H; VATPase_H, regulatory vacuolar ATP synthase subunit H (Vma13p); activation component of the peripheral V1 complex of V-ATPase, a heteromultimeric enzyme which uses ATP to actively transport protons into organelles and extracellular compartments. The ...
      cl25732
      Location:4 → 272
      SMC_N; RecF/RecN/SMC N terminal domain
      cl25751
      Location:1291 → 1701
      DUF4045; Domain of unknown function (DUF4045)

    3. NM_001127511.3 → NP_001120983.2  adenomatous polyposis coli protein isoform a

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the shorter isoform (a).
      Source sequence(s)
      AB210001, AC136500, AK294544, BP230350, CA313732
      UniProtKB/TrEMBL
      A0A224AV41
      Related
      ENSP00000423224.2, ENST00000507379.6
      Conserved Domains (13) summary
      cd00020
      Location:593 → 713
      ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
      pfam05923
      Location:1619 → 1643
      APC_crr; APC cysteine-rich region
      pfam05924
      Location:2016 → 2035
      SAMP; SAMP Motif
      pfam05937
      Location:2652 → 2825
      EB1_binding; EB-1 Binding Domain
      pfam05956
      Location:2205 → 2550
      APC_basic; APC basic domain
      pfam11414
      Location:137 → 217
      Suppressor_APC; Adenomatous polyposis coli tumour suppressor protein
      pfam16629
      Location:714 → 1001
      Arm_APC_u3; Armadillo-associated region on APC
      pfam16630
      Location:1018 → 1117
      APC_u5; Unstructured region on APC between 1st and 2nd catenin-bdg motifs
      pfam16633
      Location:1265 → 1350
      APC_u9; Unstructured region on APC between 1st two creatine-rich regions
      pfam16634
      Location:1644 → 1700
      APC_u13; Unstructured region on APC between APC_crr and SAMP
      pfam16635
      Location:1721 → 1821
      APC_u14; Unstructured region on APC between SAMP and APC_crr
      pfam16636
      Location:1858 → 1929
      APC_u15; Unstructured region on APC between APC_crr regions 5 and 6
      sd00043
      Location:447 → 490
      ARM; armadillo repeat [structural motif]

    4. NM_001354895.2 → NP_001341824.1  adenomatous polyposis coli protein isoform b

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4), as well as variants 2 and 3, encodes isoform b.
      Source sequence(s)
      AC008575, AC136500
      Consensus CDS
      CCDS4107.1
      UniProtKB/Swiss-Prot
      B7Z2B6, D3DT03, P25054, Q15162, Q15163, Q93042
      UniProtKB/TrEMBL
      A0A224ANK2
      Conserved Domains (17) summary
      smart00185
      Location:649 → 689
      ARM; Armadillo/beta-catenin-like repeats
      pfam16689
      Location:4 → 55
      APC_N_CC; Coiled-coil N-terminus of APC, dimerisation domain
      sd00043
      Location:465 → 508
      ARM; armadillo repeat [structural motif]
      pfam05923
      Location:1637 → 1660
      APC_r; APC repeat
      pfam05924
      Location:2033 → 2052
      SAMP; SAMP Motif
      pfam05937
      Location:2670 → 2843
      EB1_binding; EB-1 Binding Domain
      pfam05956
      Location:2223 → 2568
      APC_basic; APC basic domain
      pfam11414
      Location:127 → 207
      Suppressor_APC; Adenomatous polyposis coli tumor suppressor protein
      pfam16629
      Location:732 → 1018
      Arm_APC_u3; Armadillo-associated region on APC
      pfam16630
      Location:1036 → 1135
      APC_u5; Unstructured region on APC between 1st and 2nd catenin-bdg motifs
      pfam16633
      Location:1283 → 1368
      APC_u9; Unstructured region on APC between 1st two creatine-rich regions
      pfam16634
      Location:1662 → 1715
      APC_u13; Unstructured region on APC between APC_crr and SAMP
      pfam16635
      Location:1746 → 1839
      APC_u14; Unstructured region on APC between SAMP and APC_crr
      pfam16636
      Location:1873 → 1947
      APC_u15; Unstructured region on APC between APC_crr regions 5 and 6
      cl21727
      Location:533 → 734
      VATPase_H; VATPase_H, regulatory vacuolar ATP synthase subunit H (Vma13p); activation component of the peripheral V1 complex of V-ATPase, a heteromultimeric enzyme which uses ATP to actively transport protons into organelles and extracellular compartments. The ...
      cl25732
      Location:4 → 272
      SMC_N; RecF/RecN/SMC N terminal domain
      cl25751
      Location:1291 → 1701
      DUF4045; Domain of unknown function (DUF4045)

    5. NM_001354896.2 → NP_001341825.1  adenomatous polyposis coli protein isoform c

      Status: REVIEWED

      Source sequence(s)
      AC008575, AC136500
      UniProtKB/TrEMBL
      A0A224ANK2, R4GMU6
      Related
      ENSP00000473355.2, ENST00000504915.3
      Conserved Domains (17) summary
      smart00185
      Location:667 → 707
      ARM; Armadillo/beta-catenin-like repeats
      pfam00514
      Location:709 → 749
      Arm; Armadillo/beta-catenin-like repeat
      pfam16689
      Location:4 → 55
      APC_N_CC; Coiled-coil N-terminus of APC, dimerisation domain
      sd00043
      Location:581 → 613
      ARM; armadillo repeat [structural motif]
      pfam05923
      Location:1655 → 1678
      APC_r; APC repeat
      pfam05924
      Location:2051 → 2070
      SAMP; SAMP Motif
      pfam05937
      Location:2688 → 2861
      EB1_binding; EB-1 Binding Domain
      pfam05956
      Location:2241 → 2586
      APC_basic; APC basic domain
      pfam11414
      Location:127 → 207
      Suppressor_APC; Adenomatous polyposis coli tumor suppressor protein
      pfam16629
      Location:750 → 1036
      Arm_APC_u3; Armadillo-associated region on APC
      pfam16630
      Location:1054 → 1153
      APC_u5; Unstructured region on APC between 1st and 2nd catenin-bdg motifs
      pfam16633
      Location:1301 → 1386
      APC_u9; Unstructured region on APC between 1st two creatine-rich regions
      pfam16634
      Location:1680 → 1733
      APC_u13; Unstructured region on APC between APC_crr and SAMP
      pfam16635
      Location:1764 → 1857
      APC_u14; Unstructured region on APC between SAMP and APC_crr
      pfam16636
      Location:1891 → 1965
      APC_u15; Unstructured region on APC between APC_crr regions 5 and 6
      cl25732
      Location:4 → 272
      SMC_N; RecF/RecN/SMC N terminal domain
      cl25751
      Location:1309 → 1719
      DUF4045; Domain of unknown function (DUF4045)

    6. NM_001354897.2 → NP_001341826.1  adenomatous polyposis coli protein isoform d

      Status: REVIEWED

      Source sequence(s)
      AC008575, AC136500
      UniProtKB/TrEMBL
      A0A224AV41
      Conserved Domains (15) summary
      smart00185
      Location:659 → 699
      ARM; Armadillo/beta-catenin-like repeats
      pfam00514
      Location:701 → 741
      Arm; Armadillo/beta-catenin-like repeat
      sd00043
      Location:475 → 518
      ARM; armadillo repeat [structural motif]
      pfam05923
      Location:1647 → 1670
      APC_r; APC repeat
      pfam05924
      Location:2043 → 2062
      SAMP; SAMP Motif
      pfam05937
      Location:2680 → 2853
      EB1_binding; EB-1 Binding Domain
      pfam05956
      Location:2233 → 2578
      APC_basic; APC basic domain
      pfam11414
      Location:137 → 217
      Suppressor_APC; Adenomatous polyposis coli tumor suppressor protein
      pfam16629
      Location:742 → 1028
      Arm_APC_u3; Armadillo-associated region on APC
      pfam16630
      Location:1046 → 1145
      APC_u5; Unstructured region on APC between 1st and 2nd catenin-bdg motifs
      pfam16633
      Location:1293 → 1378
      APC_u9; Unstructured region on APC between 1st two creatine-rich regions
      pfam16634
      Location:1672 → 1725
      APC_u13; Unstructured region on APC between APC_crr and SAMP
      pfam16635
      Location:1756 → 1849
      APC_u14; Unstructured region on APC between SAMP and APC_crr
      pfam16636
      Location:1883 → 1957
      APC_u15; Unstructured region on APC between APC_crr regions 5 and 6
      cl25751
      Location:1301 → 1711
      DUF4045; Domain of unknown function (DUF4045)

    7. NM_001354898.2 → NP_001341827.1  adenomatous polyposis coli protein isoform e

      Status: REVIEWED

      Source sequence(s)
      AC008575, AC136500
      UniProtKB/TrEMBL
      A0A224ANK2
      Conserved Domains (15) summary
      smart00185
      Location:624 → 664
      ARM; Armadillo/beta-catenin-like repeats
      pfam00514
      Location:666 → 706
      Arm; Armadillo/beta-catenin-like repeat
      sd00043
      Location:440 → 483
      ARM; armadillo repeat [structural motif]
      pfam05923
      Location:1612 → 1635
      APC_r; APC repeat
      pfam05924
      Location:2008 → 2027
      SAMP; SAMP Motif
      pfam05937
      Location:2645 → 2818
      EB1_binding; EB-1 Binding Domain
      pfam05956
      Location:2198 → 2543
      APC_basic; APC basic domain
      pfam11414
      Location:102 → 182
      Suppressor_APC; Adenomatous polyposis coli tumor suppressor protein
      pfam16629
      Location:707 → 993
      Arm_APC_u3; Armadillo-associated region on APC
      pfam16630
      Location:1011 → 1110
      APC_u5; Unstructured region on APC between 1st and 2nd catenin-bdg motifs
      pfam16633
      Location:1258 → 1343
      APC_u9; Unstructured region on APC between 1st two creatine-rich regions
      pfam16634
      Location:1637 → 1690
      APC_u13; Unstructured region on APC between APC_crr and SAMP
      pfam16635
      Location:1721 → 1814
      APC_u14; Unstructured region on APC between SAMP and APC_crr
      pfam16636
      Location:1848 → 1922
      APC_u15; Unstructured region on APC between APC_crr regions 5 and 6
      cl25751
      Location:1266 → 1676
      DUF4045; Domain of unknown function (DUF4045)

    8. NM_001354899.2 → NP_001341828.1  adenomatous polyposis coli protein isoform f

      Status: REVIEWED

      Source sequence(s)
      AC008575, AC136500
      UniProtKB/TrEMBL
      A0A224ANK2
      Conserved Domains (16) summary
      smart00185
      Location:621 → 661
      ARM; Armadillo/beta-catenin-like repeats
      pfam00514
      Location:663 → 703
      Arm; Armadillo/beta-catenin-like repeat
      pfam16689
      Location:4 → 55
      APC_N_CC; Coiled-coil N-terminus of APC, dimerisation domain
      sd00043
      Location:437 → 480
      ARM; armadillo repeat [structural motif]
      pfam05923
      Location:1609 → 1632
      APC_r; APC repeat
      pfam05924
      Location:2005 → 2024
      SAMP; SAMP Motif
      pfam05937
      Location:2642 → 2815
      EB1_binding; EB-1 Binding Domain
      pfam05956
      Location:2195 → 2540
      APC_basic; APC basic domain
      pfam11414
      Location:127 → 207
      Suppressor_APC; Adenomatous polyposis coli tumor suppressor protein
      pfam16629
      Location:704 → 990
      Arm_APC_u3; Armadillo-associated region on APC
      pfam16630
      Location:1008 → 1107
      APC_u5; Unstructured region on APC between 1st and 2nd catenin-bdg motifs
      pfam16633
      Location:1255 → 1340
      APC_u9; Unstructured region on APC between 1st two creatine-rich regions
      pfam16634
      Location:1634 → 1687
      APC_u13; Unstructured region on APC between APC_crr and SAMP
      pfam16635
      Location:1718 → 1811
      APC_u14; Unstructured region on APC between SAMP and APC_crr
      pfam16636
      Location:1845 → 1919
      APC_u15; Unstructured region on APC between APC_crr regions 5 and 6
      cl25751
      Location:1263 → 1673
      DUF4045; Domain of unknown function (DUF4045)

    9. NM_001354900.2 → NP_001341829.1  adenomatous polyposis coli protein isoform g

      Status: REVIEWED

      Source sequence(s)
      AC008575, AC136500
      UniProtKB/TrEMBL
      A0AAQ5BGJ9
      Conserved Domains (15) summary
      smart00185
      Location:608 → 648
      ARM; Armadillo/beta-catenin-like repeats
      pfam00514
      Location:650 → 690
      Arm; Armadillo/beta-catenin-like repeat
      sd00043
      Location:522 → 554
      ARM; armadillo repeat [structural motif]
      pfam05923
      Location:1596 → 1619
      APC_r; APC repeat
      pfam05924
      Location:1992 → 2011
      SAMP; SAMP Motif
      pfam05937
      Location:2629 → 2802
      EB1_binding; EB-1 Binding Domain
      pfam05956
      Location:2182 → 2527
      APC_basic; APC basic domain
      pfam11414
      Location:68 → 148
      Suppressor_APC; Adenomatous polyposis coli tumor suppressor protein
      pfam16629
      Location:691 → 977
      Arm_APC_u3; Armadillo-associated region on APC
      pfam16630
      Location:995 → 1094
      APC_u5; Unstructured region on APC between 1st and 2nd catenin-bdg motifs
      pfam16633
      Location:1242 → 1327
      APC_u9; Unstructured region on APC between 1st two creatine-rich regions
      pfam16634
      Location:1621 → 1674
      APC_u13; Unstructured region on APC between APC_crr and SAMP
      pfam16635
      Location:1705 → 1798
      APC_u14; Unstructured region on APC between SAMP and APC_crr
      pfam16636
      Location:1832 → 1906
      APC_u15; Unstructured region on APC between APC_crr regions 5 and 6
      cl25751
      Location:1250 → 1660
      DUF4045; Domain of unknown function (DUF4045)

    10. NM_001354901.2 → NP_001341830.1  adenomatous polyposis coli protein isoform h

      Status: REVIEWED

      Source sequence(s)
      AC008575, AC136500
      UniProtKB/TrEMBL
      A0AAQ5BGJ9
      Related
      ENSP00000518940.1, ENST00000713639.1
      Conserved Domains (15) summary
      smart00185
      Location:590 → 630
      ARM; Armadillo/beta-catenin-like repeats
      pfam00514
      Location:632 → 672
      Arm; Armadillo/beta-catenin-like repeat
      sd00043
      Location:406 → 449
      ARM; armadillo repeat [structural motif]
      pfam05923
      Location:1578 → 1601
      APC_r; APC repeat
      pfam05924
      Location:1974 → 1993
      SAMP; SAMP Motif
      pfam05937
      Location:2611 → 2784
      EB1_binding; EB-1 Binding Domain
      pfam05956
      Location:2164 → 2509
      APC_basic; APC basic domain
      pfam11414
      Location:68 → 148
      Suppressor_APC; Adenomatous polyposis coli tumor suppressor protein
      pfam16629
      Location:673 → 959
      Arm_APC_u3; Armadillo-associated region on APC
      pfam16630
      Location:977 → 1076
      APC_u5; Unstructured region on APC between 1st and 2nd catenin-bdg motifs
      pfam16633
      Location:1224 → 1309
      APC_u9; Unstructured region on APC between 1st two creatine-rich regions
      pfam16634
      Location:1603 → 1656
      APC_u13; Unstructured region on APC between APC_crr and SAMP
      pfam16635
      Location:1687 → 1780
      APC_u14; Unstructured region on APC between SAMP and APC_crr
      pfam16636
      Location:1814 → 1888
      APC_u15; Unstructured region on APC between APC_crr regions 5 and 6
      cl25751
      Location:1232 → 1642
      DUF4045; Domain of unknown function (DUF4045)

    11. NM_001354902.2 → NP_001341831.1  adenomatous polyposis coli protein isoform i

      Status: REVIEWED

      Source sequence(s)
      AC008575, AC136500
      UniProtKB/TrEMBL
      A0A224AV41
      Conserved Domains (15) summary
      smart00185
      Location:558 → 598
      ARM; Armadillo/beta-catenin-like repeats
      pfam00514
      Location:600 → 640
      Arm; Armadillo/beta-catenin-like repeat
      sd00043
      Location:374 → 417
      ARM; armadillo repeat [structural motif]
      pfam05923
      Location:1546 → 1569
      APC_r; APC repeat
      pfam05924
      Location:1942 → 1961
      SAMP; SAMP Motif
      pfam05937
      Location:2579 → 2752
      EB1_binding; EB-1 Binding Domain
      pfam05956
      Location:2132 → 2477
      APC_basic; APC basic domain
      pfam11414
      Location:137 → 217
      Suppressor_APC; Adenomatous polyposis coli tumor suppressor protein
      pfam16629
      Location:641 → 927
      Arm_APC_u3; Armadillo-associated region on APC
      pfam16630
      Location:945 → 1044
      APC_u5; Unstructured region on APC between 1st and 2nd catenin-bdg motifs
      pfam16633
      Location:1192 → 1277
      APC_u9; Unstructured region on APC between 1st two creatine-rich regions
      pfam16634
      Location:1571 → 1624
      APC_u13; Unstructured region on APC between APC_crr and SAMP
      pfam16635
      Location:1655 → 1748
      APC_u14; Unstructured region on APC between SAMP and APC_crr
      pfam16636
      Location:1782 → 1856
      APC_u15; Unstructured region on APC between APC_crr regions 5 and 6
      cl25751
      Location:1200 → 1610
      DUF4045; Domain of unknown function (DUF4045)

    12. NM_001354903.2 → NP_001341832.1  adenomatous polyposis coli protein isoform j

      Status: REVIEWED

      Source sequence(s)
      AC008575, AC136500
      UniProtKB/TrEMBL
      A0A224ANK2
      Conserved Domains (17) summary
      smart00185
      Location:548 → 588
      ARM; Armadillo/beta-catenin-like repeats
      pfam00514
      Location:590 → 630
      Arm; Armadillo/beta-catenin-like repeat
      pfam16689
      Location:4 → 55
      APC_N_CC; Coiled-coil N-terminus of APC, dimerisation domain
      sd00043
      Location:364 → 407
      ARM; armadillo repeat [structural motif]
      pfam05923
      Location:1536 → 1559
      APC_r; APC repeat
      pfam05924
      Location:1932 → 1951
      SAMP; SAMP Motif
      pfam05937
      Location:2569 → 2742
      EB1_binding; EB-1 Binding Domain
      pfam05956
      Location:2122 → 2467
      APC_basic; APC basic domain
      pfam11414
      Location:127 → 207
      Suppressor_APC; Adenomatous polyposis coli tumor suppressor protein
      pfam16629
      Location:631 → 917
      Arm_APC_u3; Armadillo-associated region on APC
      pfam16630
      Location:935 → 1034
      APC_u5; Unstructured region on APC between 1st and 2nd catenin-bdg motifs
      pfam16633
      Location:1182 → 1267
      APC_u9; Unstructured region on APC between 1st two creatine-rich regions
      pfam16634
      Location:1561 → 1614
      APC_u13; Unstructured region on APC between APC_crr and SAMP
      pfam16635
      Location:1645 → 1738
      APC_u14; Unstructured region on APC between SAMP and APC_crr
      pfam16636
      Location:1772 → 1846
      APC_u15; Unstructured region on APC between APC_crr regions 5 and 6
      cl25732
      Location:4 → 272
      SMC_N; RecF/RecN/SMC N terminal domain
      cl25751
      Location:1190 → 1600
      DUF4045; Domain of unknown function (DUF4045)

    13. NM_001354904.2 → NP_001341833.1  adenomatous polyposis coli protein isoform k

      Status: REVIEWED

      Source sequence(s)
      AC008575, AC136500
      UniProtKB/TrEMBL
      A0AAQ5BGJ9
      Conserved Domains (15) summary
      smart00185
      Location:523 → 563
      ARM; Armadillo/beta-catenin-like repeats
      pfam00514
      Location:565 → 605
      Arm; Armadillo/beta-catenin-like repeat
      sd00043
      Location:339 → 382
      ARM; armadillo repeat [structural motif]
      pfam05923
      Location:1511 → 1534
      APC_r; APC repeat
      pfam05924
      Location:1907 → 1926
      SAMP; SAMP Motif
      pfam05937
      Location:2544 → 2717
      EB1_binding; EB-1 Binding Domain
      pfam05956
      Location:2097 → 2442
      APC_basic; APC basic domain
      pfam11414
      Location:102 → 182
      Suppressor_APC; Adenomatous polyposis coli tumor suppressor protein
      pfam16629
      Location:606 → 892
      Arm_APC_u3; Armadillo-associated region on APC
      pfam16630
      Location:910 → 1009
      APC_u5; Unstructured region on APC between 1st and 2nd catenin-bdg motifs
      pfam16633
      Location:1157 → 1242
      APC_u9; Unstructured region on APC between 1st two creatine-rich regions
      pfam16634
      Location:1536 → 1589
      APC_u13; Unstructured region on APC between APC_crr and SAMP
      pfam16635
      Location:1620 → 1713
      APC_u14; Unstructured region on APC between SAMP and APC_crr
      pfam16636
      Location:1747 → 1821
      APC_u15; Unstructured region on APC between APC_crr regions 5 and 6
      cl25751
      Location:1165 → 1575
      DUF4045; Domain of unknown function (DUF4045)

    14. NM_001354905.2 → NP_001341834.1  adenomatous polyposis coli protein isoform l

      Status: REVIEWED

      Source sequence(s)
      AC008575, AC136500
      UniProtKB/TrEMBL
      A0AAQ5BGJ9
      Conserved Domains (15) summary
      smart00185
      Location:489 → 529
      ARM; Armadillo/beta-catenin-like repeats
      pfam00514
      Location:531 → 571
      Arm; Armadillo/beta-catenin-like repeat
      sd00043
      Location:305 → 348
      ARM; armadillo repeat [structural motif]
      pfam05923
      Location:1477 → 1500
      APC_r; APC repeat
      pfam05924
      Location:1873 → 1892
      SAMP; SAMP Motif
      pfam05937
      Location:2510 → 2683
      EB1_binding; EB-1 Binding Domain
      pfam05956
      Location:2063 → 2408
      APC_basic; APC basic domain
      pfam11414
      Location:68 → 148
      Suppressor_APC; Adenomatous polyposis coli tumor suppressor protein
      pfam16629
      Location:572 → 858
      Arm_APC_u3; Armadillo-associated region on APC
      pfam16630
      Location:876 → 975
      APC_u5; Unstructured region on APC between 1st and 2nd catenin-bdg motifs
      pfam16633
      Location:1123 → 1208
      APC_u9; Unstructured region on APC between 1st two creatine-rich regions
      pfam16634
      Location:1502 → 1555
      APC_u13; Unstructured region on APC between APC_crr and SAMP
      pfam16635
      Location:1586 → 1679
      APC_u14; Unstructured region on APC between SAMP and APC_crr
      pfam16636
      Location:1713 → 1787
      APC_u15; Unstructured region on APC between APC_crr regions 5 and 6
      cl25751
      Location:1131 → 1541
      DUF4045; Domain of unknown function (DUF4045)

    15. NM_001354906.2 → NP_001341835.1  adenomatous polyposis coli protein isoform m

      Status: REVIEWED

      Source sequence(s)
      AC008575, AC136500
      UniProtKB/TrEMBL
      A0AAQ5BGJ9
      Conserved Domains (14) summary
      smart00185
      Location:366 → 406
      ARM; Armadillo/beta-catenin-like repeats
      pfam00514
      Location:408 → 448
      Arm; Armadillo/beta-catenin-like repeat
      sd00043
      Location:182 → 225
      ARM; armadillo repeat [structural motif]
      pfam05923
      Location:1354 → 1377
      APC_r; APC repeat
      pfam05924
      Location:1750 → 1769
      SAMP; SAMP Motif
      pfam05937
      Location:2387 → 2560
      EB1_binding; EB-1 Binding Domain
      pfam05956
      Location:1940 → 2285
      APC_basic; APC basic domain
      pfam16629
      Location:449 → 735
      Arm_APC_u3; Armadillo-associated region on APC
      pfam16630
      Location:753 → 852
      APC_u5; Unstructured region on APC between 1st and 2nd catenin-bdg motifs
      pfam16633
      Location:1000 → 1085
      APC_u9; Unstructured region on APC between 1st two creatine-rich regions
      pfam16634
      Location:1379 → 1432
      APC_u13; Unstructured region on APC between APC_crr and SAMP
      pfam16635
      Location:1463 → 1556
      APC_u14; Unstructured region on APC between SAMP and APC_crr
      pfam16636
      Location:1590 → 1664
      APC_u15; Unstructured region on APC between APC_crr regions 5 and 6
      cl25751
      Location:1008 → 1418
      DUF4045; Domain of unknown function (DUF4045)

    16. NM_001407446.1 → NP_001394375.1  adenomatous polyposis coli protein isoform n

      Status: REVIEWED

      Source sequence(s)
      AC008575, AC136500
      UniProtKB/TrEMBL
      A0A224AV41

    17. NM_001407447.1 → NP_001394376.1  adenomatous polyposis coli protein isoform c

      Status: REVIEWED

      Source sequence(s)
      AC008575, AC136500
      UniProtKB/TrEMBL
      A0A224ANK2, R4GMU6

    18. NM_001407448.1 → NP_001394377.1  adenomatous polyposis coli protein isoform c

      Status: REVIEWED

      Source sequence(s)
      AC008575, AC136500
      UniProtKB/TrEMBL
      A0A224ANK2, R4GMU6

    19. NM_001407449.1 → NP_001394378.1  adenomatous polyposis coli protein isoform c

      Status: REVIEWED

      Source sequence(s)
      AC008575, AC136500
      UniProtKB/TrEMBL
      A0A224ANK2, R4GMU6

    20. NM_001407450.1 → NP_001394379.1  adenomatous polyposis coli protein isoform b

      Status: REVIEWED

      Source sequence(s)
      AC008575, AC136500
      UniProtKB/Swiss-Prot
      B7Z2B6, D3DT03, P25054, Q15162, Q15163, Q93042
      UniProtKB/TrEMBL
      A0A224ANK2
      Related
      ENSP00000426541.2, ENST00000509732.6

    21. NM_001407451.1 → NP_001394380.1  adenomatous polyposis coli protein isoform o

      Status: REVIEWED

      Source sequence(s)
      AC008575, AC136500
      UniProtKB/TrEMBL
      A0A224ANK2

    22. NM_001407452.1 → NP_001394381.1  adenomatous polyposis coli protein isoform p

      Status: REVIEWED

      Source sequence(s)
      AC008575, AC136500
      UniProtKB/TrEMBL
      A0A224ANK2

    23. NM_001407453.1 → NP_001394382.1  adenomatous polyposis coli protein isoform h

      Status: REVIEWED

      Source sequence(s)
      AC008575, AC136500
      UniProtKB/TrEMBL
      A0AAQ5BGJ9

    24. NM_001407454.1 → NP_001394383.1  adenomatous polyposis coli protein isoform q

      Status: REVIEWED

      Source sequence(s)
      AC008575, AC136500
      UniProtKB/TrEMBL
      A0A224ANK2

    25. NM_001407455.1 → NP_001394384.1  adenomatous polyposis coli protein isoform q

      Status: REVIEWED

      Source sequence(s)
      AC008575, AC136500
      UniProtKB/TrEMBL
      A0A224ANK2

    26. NM_001407456.1 → NP_001394385.1  adenomatous polyposis coli protein isoform q

      Status: REVIEWED

      Source sequence(s)
      AC008575, AC136500
      UniProtKB/TrEMBL
      A0A224ANK2

    27. NM_001407457.1 → NP_001394386.1  adenomatous polyposis coli protein isoform q

      Status: REVIEWED

      Source sequence(s)
      AC008575, AC136500
      UniProtKB/TrEMBL
      A0A224ANK2

    28. NM_001407458.1 → NP_001394387.1  adenomatous polyposis coli protein isoform j

      Status: REVIEWED

      Source sequence(s)
      AC008575, AC136500
      UniProtKB/TrEMBL
      A0A224ANK2

    29. NM_001407459.1 → NP_001394388.1  adenomatous polyposis coli protein isoform j

      Status: REVIEWED

      Source sequence(s)
      AC008575, AC136500
      UniProtKB/TrEMBL
      A0A224ANK2

    30. NM_001407460.1 → NP_001394389.1  adenomatous polyposis coli protein isoform j

      Status: REVIEWED

      Source sequence(s)
      AC008575, AC136500
      UniProtKB/TrEMBL
      A0A224ANK2

    31. NM_001407467.1 → NP_001394396.1  adenomatous polyposis coli protein isoform r

      Status: REVIEWED

      Source sequence(s)
      AC008575, AC136500
      UniProtKB/TrEMBL
      A0A224ANK2

    32. NM_001407469.1 → NP_001394398.1  adenomatous polyposis coli protein isoform r

      Status: REVIEWED

      Source sequence(s)
      AC008575, AC136500
      UniProtKB/TrEMBL
      A0A224ANK2

    33. NM_001407470.1 → NP_001394399.1  adenomatous polyposis coli protein isoform m

      Status: REVIEWED

      Source sequence(s)
      AC008575, AC136500
      UniProtKB/TrEMBL
      A0AAQ5BGJ9

    34. NM_001407471.1 → NP_001394400.1  adenomatous polyposis coli protein isoform s

      Status: REVIEWED

      Source sequence(s)
      AC008575, AC136500
      UniProtKB/TrEMBL
      A0AAQ5BGJ9

    35. NM_001407472.1 → NP_001394401.1  adenomatous polyposis coli protein isoform s

      Status: REVIEWED

      Source sequence(s)
      AC008575, AC136500
      UniProtKB/TrEMBL
      A0AAQ5BGJ9

    RNA

    1. NR_176365.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC008575, AC136500
      Related
      ENST00000505350.2

    2. NR_176366.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC008575, AC136500

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

      Range
      112707498..112846239
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060929.1 Alternate T2T-CHM13v2.0

      Range
      113218062..113356772
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P25054.2 GenPept UniProtKB/Swiss-Prot:P25054

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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