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    Tecpr1 tectonin beta-propeller repeat containing 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 304285, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Tecpr1provided by RGD
    Official Full Name
    tectonin beta-propeller repeat containing 1provided by RGD
    Primary source
    RGD:1306873
    See related
    EnsemblRapid:ENSRNOG00000001010 AllianceGenome:RGD:1306873
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1306873
    Summary
    Predicted to enable phosphatidylinositol-3-phosphate binding activity. Predicted to be involved in autophagosome maturation and regulation of autophagosome maturation. Predicted to be located in nucleoplasm. Predicted to be active in autophagosome membrane and lysosomal membrane. Orthologous to human TECPR1 (tectonin beta-propeller repeat containing 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 82.4), Lung (RPKM 78.6) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Tecpr1 in Genome Data Viewer
    Location:
    12p11
    Exon count:
    27
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 12 NC_086030.1 (15504456..15534541)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 12 NC_051347.1 (10391587..10420462)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 12 NC_005111.4 (12374132..12403382)

    Chromosome 12 - NC_086030.1Genomic Context describing neighboring genes Neighboring gene BAR/IMD domain containing adaptor protein 2 like 1 Neighboring gene ubiquitin-conjugating enzyme E2N, pseudogene 5 Neighboring gene uncharacterized LOC102554669 Neighboring gene brain protein I3 Neighboring gene basic helix-loop-helix family, member a15 Neighboring gene lemur tyrosine kinase 2 Neighboring gene elongation factor 1-gamma-like Neighboring gene oncomodulin

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. A mammalian autophagosome maturation mechanism mediated by TECPR1 and the Atg12-Atg5 conjugate. Chen D, et al. Mol Cell, 2012 Mar 9. PMID 22342342, Free PMC Article
    2. A Tecpr1-dependent selective autophagy pathway targets bacterial pathogens. Ogawa M, et al. Cell Host Microbe, 2011 May 19. PMID 21575909
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC124730

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables phosphatidylinositol-3-phosphate binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phosphatidylinositol-3-phosphate binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables phosphatidylinositol-3-phosphate binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in autophagosome maturation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in autophagosome maturation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in autophagosome maturation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in autophagy ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in autophagy ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in macroautophagy ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of autophagosome maturation ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in autophagosome membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in autophagosome membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in autophagosome membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in cytoplasmic vesicle IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in lysosomal membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in lysosomal membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in lysosomal membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    tectonin beta-propeller repeat-containing protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001037191.1 → NP_001032268.1  tectonin beta-propeller repeat-containing protein 1

      See identical proteins and their annotated locations for NP_001032268.1

      Status: PROVISIONAL

      Source sequence(s)
      BC103478
      UniProtKB/Swiss-Prot
      Q3ZBA0
      Conserved Domains (6) summary
      smart00694
      Location:893 → 926
      DysFC; Dysferlin domain, C-terminal region
      smart00693
      Location:64 → 125
      DysFN; Dysferlin domain, N-terminal region
      smart00706
      Location:234 → 270
      TECPR; Beta propeller repeats in Physarum polycephalum tectonins, Limulus lectin L-6 and animal hypothetical proteins
      cd13300
      Location:609 → 729
      PH1_TECPR1; Tectonin beta-propeller repeat-containing protein 1 Pleckstrin homology (PH) domain, repeat 1
      pfam00169
      Location:615 → 721
      PH; PH domain
      pfam06462
      Location:303 → 331
      Hyd_WA; Propeller

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086030.1 Reference GRCr8

      Range
      15504456..15534541
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017598316.3 → XP_017453805.1  tectonin beta-propeller repeat-containing protein 1 isoform X1

      UniProtKB/Swiss-Prot
      Q3ZBA0
      Related
      ENSRNOP00000001347.5, ENSRNOT00000001347.9
      Conserved Domains (6) summary
      smart00694
      Location:893 → 926
      DysFC; Dysferlin domain, C-terminal region
      smart00693
      Location:64 → 125
      DysFN; Dysferlin domain, N-terminal region
      smart00706
      Location:234 → 270
      TECPR; Beta propeller repeats in Physarum polycephalum tectonins, Limulus lectin L-6 and animal hypothetical proteins
      cd13300
      Location:609 → 729
      PH1_TECPR1; Tectonin beta-propeller repeat-containing protein 1 Pleckstrin homology (PH) domain, repeat 1
      pfam00169
      Location:615 → 721
      PH; PH domain
      pfam06462
      Location:303 → 331
      Hyd_WA; Propeller

    2. XM_039089351.2 → XP_038945279.1  tectonin beta-propeller repeat-containing protein 1 isoform X3

      UniProtKB/TrEMBL
      A6K1H9
      Conserved Domains (6) summary
      smart00694
      Location:563 → 596
      DysFC; Dysferlin domain, C-terminal region
      smart00693
      Location:491 → 552
      DysFN; Dysferlin domain, N-terminal region
      smart00706
      Location:436 → 469
      TECPR; Beta propeller repeats in Physarum polycephalum tectonins, Limulus lectin L-6 and animal hypothetical proteins
      cd13300
      Location:279 → 399
      PH1_TECPR1; Tectonin beta-propeller repeat-containing protein 1 Pleckstrin homology (PH) domain, repeat 1
      pfam06462
      Location:15 → 45
      Hyd_WA; Propeller
      pfam19193
      Location:620 → 767
      Tectonin; Tectonin domain

    3. XM_039089350.2 → XP_038945278.1  tectonin beta-propeller repeat-containing protein 1 isoform X2

      UniProtKB/TrEMBL
      A6K1H9
      Conserved Domains (6) summary
      smart00694
      Location:576 → 609
      DysFC; Dysferlin domain, C-terminal region
      smart00693
      Location:504 → 565
      DysFN; Dysferlin domain, N-terminal region
      smart00706
      Location:449 → 482
      TECPR; Beta propeller repeats in Physarum polycephalum tectonins, Limulus lectin L-6 and animal hypothetical proteins
      cd13300
      Location:292 → 412
      PH1_TECPR1; Tectonin beta-propeller repeat-containing protein 1 Pleckstrin homology (PH) domain, repeat 1
      pfam06462
      Location:29 → 58
      Hyd_WA; Propeller
      pfam19193
      Location:633 → 780
      Tectonin; Tectonin domain

    RNA

    1. XR_005491622.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q3ZBA0.1 GenPept UniProtKB/Swiss-Prot:Q3ZBA0

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