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    g6pd glucose-6-phosphate dehydrogenase [ Danio rerio (zebrafish) ]

    Gene ID: 570579, updated on 27-Dec-2024

    Summary

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    Official Symbol
    g6pdprovided by ZNC
    Official Full Name
    glucose-6-phosphate dehydrogenaseprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-070508-4
    See related
    Ensembl:ENSDARG00000071065 AllianceGenome:ZFIN:ZDB-GENE-070508-4
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    fj78b06; wu:fj78b06; si:dkey-90a13.8
    Summary
    Enables UDP-glucose 6-dehydrogenase activity and glucose-6-phosphate dehydrogenase activity. Acts upstream of or within epiboly. Used to study hemolytic anemia. Human ortholog(s) of this gene implicated in several diseases, including anemia (multiple); cerebrovascular disease; favism; malaria (multiple); and neonatal jaundice. Orthologous to human G6PD (glucose-6-phosphate dehydrogenase). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See g6pd in Genome Data Viewer
    Location:
    chromosome: 23
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 23 NC_007134.7 (13844920..13874758, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 23 NC_007134.6 (14088843..14118717, complement)

    Chromosome 23 - NC_007134.7Genomic Context describing neighboring genes Neighboring gene leiomodin 3 (fetal) Neighboring gene N-alpha-acetyltransferase 10, NatA catalytic subuni Neighboring gene uncharacterized LOC108181454 Neighboring gene sperm microtubule inner protein 11

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. A model of glucose-6-phosphate dehydrogenase deficiency in the zebrafish. Patrinostro X, et al. Exp Hematol, 2013 Aug. PMID 23603363, Free PMC Article
    2. Polygoni multiflori radix extracts inhibit SARS-CoV-2 pseudovirus entry in HEK293T cells and zebrafish larvae. Wang X, et al. Phytomedicine, 2022 Jul 20. PMID 35576740, Free PMC Article
    3. Correcting glucose-6-phosphate dehydrogenase deficiency with a small-molecule activator. Hwang S, et al. Nat Commun, 2018 Oct 2. PMID 30279493, Free PMC Article
    4. Traditional African remedies induce hemolysis in a glucose-6-phopshate dehydrogenase deficient zebrafish model. Arogbokun O, et al. Sci Rep, 2020 Nov 5. PMID 33154437, Free PMC Article
    5. SLAM-ITseq identifies that Nrf2 induces liver regeneration through the pentose phosphate pathway. Tan VWT, et al. Dev Cell, 2024 Apr 8. PMID 38366599

    See all (55) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The vitamin B6-regulated enzymes PYGL and G6PD fuel NADPH oxidases to promote skin inflammation.
      Title: The vitamin B6-regulated enzymes PYGL and G6PD fuel NADPH oxidases to promote skin inflammation.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables NADP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables UDP-glucose 6-dehydrogenase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables glucose-6-phosphate dehydrogenase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables glucose-6-phosphate dehydrogenase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity, acting on CH-OH group of donors IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within epiboly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within glucose metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    glucose-6-phosphate 1-dehydrogenase

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007134.7 Reference GRCz11 Primary Assembly

      Range
      13844920..13874758 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_694076.9 → XP_699168.3  glucose-6-phosphate 1-dehydrogenase isoform X3

      UniProtKB/TrEMBL
      A0A8M9PT34, F6NHI0
      Related
      ENSDARP00000115363.1, ENSDART00000138696.2
      Conserved Domains (1) summary
      cl27363
      Location:37 → 523
      G6PD_C; Glucose-6-phosphate dehydrogenase, C-terminal domain

    2. XM_005162010.5 → XP_005162067.1  glucose-6-phosphate 1-dehydrogenase isoform X1

      UniProtKB/TrEMBL
      A0A8M2B959
      Conserved Domains (1) summary
      cl27363
      Location:48 → 534
      G6PD_C; Glucose-6-phosphate dehydrogenase, C-terminal domain

    3. XM_009296703.4 → XP_009294978.2  glucose-6-phosphate 1-dehydrogenase isoform X2

      UniProtKB/TrEMBL
      A0A8M3AY75
      Conserved Domains (1) summary
      cl27363
      Location:42 → 528
      G6PD_C; Glucose-6-phosphate dehydrogenase, C-terminal domain

    4. XM_068216878.1 → XP_068072979.1  glucose-6-phosphate 1-dehydrogenase isoform X4

      UniProtKB/TrEMBL
      A0A8M9Q598, E7FDY7

    5. XM_068216877.1 → XP_068072978.1  glucose-6-phosphate 1-dehydrogenase isoform X4

      UniProtKB/TrEMBL
      A0A8M9Q598, E7FDY7
      Related
      ENSDARP00000151797.1, ENSDART00000193807.1

    6. XM_009296704.4 → XP_009294979.1  glucose-6-phosphate 1-dehydrogenase isoform X4

      See identical proteins and their annotated locations for XP_009294979.1

      UniProtKB/TrEMBL
      A0A8M9Q598, E7FDY7
      Conserved Domains (1) summary
      cl27363
      Location:27 → 513
      G6PD_C; Glucose-6-phosphate dehydrogenase, C-terminal domain

    7. XM_009296706.4 → XP_009294981.1  glucose-6-phosphate 1-dehydrogenase isoform X4

      See identical proteins and their annotated locations for XP_009294981.1

      UniProtKB/TrEMBL
      A0A8M9Q598, E7FDY7
      Related
      ENSDARP00000095604.4, ENSDART00000104834.6
      Conserved Domains (1) summary
      cl27363
      Location:27 → 513
      G6PD_C; Glucose-6-phosphate dehydrogenase, C-terminal domain

    8. XM_021469916.2 → XP_021325591.1  glucose-6-phosphate 1-dehydrogenase isoform X4

      UniProtKB/TrEMBL
      A0A8M9Q598, E7FDY7
      Conserved Domains (1) summary
      cl27363
      Location:27 → 513
      G6PD_C; Glucose-6-phosphate dehydrogenase, C-terminal domain

    9. XM_017353737.3 → XP_017209226.1  glucose-6-phosphate 1-dehydrogenase isoform X4

      UniProtKB/TrEMBL
      A0A8M9Q598, E7FDY7
      Conserved Domains (1) summary
      cl27363
      Location:27 → 513
      G6PD_C; Glucose-6-phosphate dehydrogenase, C-terminal domain

    Reference GRCz11 ALT_DRER_TU_1

    Genomic

    1. NW_018395134.1 Reference GRCz11 ALT_DRER_TU_1

      Range
      153055..182734 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_021473587.2 → XP_021329262.1  glucose-6-phosphate 1-dehydrogenase isoform X3

      UniProtKB/TrEMBL
      A0A8M9PDT5
      Conserved Domains (1) summary
      cl27363
      Location:37 → 523
      G6PD_C; Glucose-6-phosphate dehydrogenase, C-terminal domain

    2. XM_021473585.2 → XP_021329260.1  glucose-6-phosphate 1-dehydrogenase isoform X1

      UniProtKB/TrEMBL
      A0A8M9Q7P5
      Conserved Domains (1) summary
      cl27363
      Location:48 → 534
      G6PD_C; Glucose-6-phosphate dehydrogenase, C-terminal domain

    3. XM_021473586.2 → XP_021329261.1  glucose-6-phosphate 1-dehydrogenase isoform X2

      UniProtKB/TrEMBL
      A0A8M9Q3J7
      Conserved Domains (1) summary
      cl27363
      Location:42 → 528
      G6PD_C; Glucose-6-phosphate dehydrogenase, C-terminal domain

    4. XM_068219028.1 → XP_068075129.1  glucose-6-phosphate 1-dehydrogenase isoform X4

      UniProtKB/TrEMBL
      A0A8M9PWR3

    5. XM_021473588.2 → XP_021329263.1  glucose-6-phosphate 1-dehydrogenase isoform X4

      UniProtKB/TrEMBL
      A0A8M9PWR3
      Conserved Domains (1) summary
      cl27363
      Location:27 → 513
      G6PD_C; Glucose-6-phosphate dehydrogenase, C-terminal domain

    6. XM_021473590.2 → XP_021329265.1  glucose-6-phosphate 1-dehydrogenase isoform X4

      UniProtKB/TrEMBL
      A0A8M9PWR3
      Conserved Domains (1) summary
      cl27363
      Location:27 → 513
      G6PD_C; Glucose-6-phosphate dehydrogenase, C-terminal domain

    Reference GRCz11 ALT_DRER_TU_2

    Genomic

    1. NW_018395358.1 Reference GRCz11 ALT_DRER_TU_2

      Range
      61063..90901 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_021474503.2 → XP_021330178.1  glucose-6-phosphate 1-dehydrogenase isoform X3

      UniProtKB/TrEMBL
      A0A8M9PT34, F6NHI0
      Conserved Domains (1) summary
      cl27363
      Location:37 → 523
      G6PD_C; Glucose-6-phosphate dehydrogenase, C-terminal domain

    2. XM_021474501.2 → XP_021330176.1  glucose-6-phosphate 1-dehydrogenase isoform X1

      UniProtKB/TrEMBL
      A0A8M2B959
      Conserved Domains (1) summary
      cl27363
      Location:48 → 534
      G6PD_C; Glucose-6-phosphate dehydrogenase, C-terminal domain

    3. XM_021474502.2 → XP_021330177.1  glucose-6-phosphate 1-dehydrogenase isoform X2

      UniProtKB/TrEMBL
      A0A8M3AY75
      Conserved Domains (1) summary
      cl27363
      Location:42 → 528
      G6PD_C; Glucose-6-phosphate dehydrogenase, C-terminal domain

    4. XM_068219381.1 → XP_068075482.1  glucose-6-phosphate 1-dehydrogenase isoform X4

      UniProtKB/TrEMBL
      A0A8M9Q598, E7FDY7

    5. XM_068219380.1 → XP_068075481.1  glucose-6-phosphate 1-dehydrogenase isoform X4

      UniProtKB/TrEMBL
      A0A8M9Q598, E7FDY7

    6. XM_021474504.2 → XP_021330179.1  glucose-6-phosphate 1-dehydrogenase isoform X4

      UniProtKB/TrEMBL
      A0A8M9Q598, E7FDY7
      Conserved Domains (1) summary
      cl27363
      Location:27 → 513
      G6PD_C; Glucose-6-phosphate dehydrogenase, C-terminal domain

    7. XM_021474506.2 → XP_021330181.1  glucose-6-phosphate 1-dehydrogenase isoform X4

      UniProtKB/TrEMBL
      A0A8M9Q598, E7FDY7
      Conserved Domains (1) summary
      cl27363
      Location:27 → 513
      G6PD_C; Glucose-6-phosphate dehydrogenase, C-terminal domain

    8. XM_021474505.2 → XP_021330180.1  glucose-6-phosphate 1-dehydrogenase isoform X4

      UniProtKB/TrEMBL
      A0A8M9Q598, E7FDY7
      Conserved Domains (1) summary
      cl27363
      Location:27 → 513
      G6PD_C; Glucose-6-phosphate dehydrogenase, C-terminal domain

    9. XM_021474507.2 → XP_021330182.1  glucose-6-phosphate 1-dehydrogenase isoform X4

      UniProtKB/TrEMBL
      A0A8M9Q598, E7FDY7
      Conserved Domains (1) summary
      cl27363
      Location:27 → 513
      G6PD_C; Glucose-6-phosphate dehydrogenase, C-terminal domain
    Nucleotide Protein Strain
    Heading Accession and Version

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