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    idua alpha-L-iduronidase [ Danio rerio (zebrafish) ]

    Gene ID: 567720, updated on 9-Dec-2024

    Summary

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    Official Symbol
    iduaprovided by ZNC
    Official Full Name
    alpha-L-iduronidaseprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-060526-29
    See related
    Ensembl:ENSDARG00000062904 AllianceGenome:ZFIN:ZDB-GENE-060526-29
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    si:ch211-12e13.9
    Summary
    Predicted to enable L-iduronidase activity. Predicted to act upstream of or within carbohydrate metabolic process. Human ortholog(s) of this gene implicated in Scheie syndrome; mucopolysaccharidosis I; mucopolysaccharidosis Ih; and mucopolysaccharidosis Ih/s. Orthologous to human IDUA (alpha-L-iduronidase). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See idua in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 5 NC_007116.7 (9047436..9068809)
    105 previous assembly GRCz10 (GCF_000002035.5) 5 NC_007116.6 (8542785..8563228)

    Chromosome 5 - NC_007116.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC100002472 Neighboring gene si:ch211-155m12.1 Neighboring gene ATP synthase membrane subunit eb Neighboring gene potassium channel, subfamily V, member 2b

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Identification of an α-l-iduronidase (IDUA) M1T mutation in a Chinese family with autosomal recessive mucopolysaccharidosis I. Liu D, et al. Ann N Y Acad Sci, 2023 Aug. PMID 37347427
    2. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article
    4. Gene evolution and gene expression after whole genome duplication in fish: the PhyloFish database. Pasquier J, et al. BMC Genomics, 2016 May 18. PMID 27189481, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables L-iduronidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity, acting on glycosyl bonds IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity, hydrolyzing O-glycosyl compounds IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within carbohydrate metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    alpha-L-iduronidase
    Names
    iduronidase alpha-L-
    XP_001923689.3
    XP_021327244.1
    XP_021329683.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007116.7 Reference GRCz11 Primary Assembly

      Range
      9047436..9068809
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_001923654.8 → XP_001923689.3  alpha-L-iduronidase

      UniProtKB/TrEMBL
      A0A8M1QHX7, A2ARH2, A3KGU3, X1WCH0
      Related
      ENSDARP00000085896.6, ENSDART00000091463.7
      Conserved Domains (1) summary
      cl23725
      Location:33 → 538
      Glyco_hydro_1; Glycosyl hydrolase family 1

    Reference GRCz11 ALT_DRER_TU_1

    Genomic

    1. NW_018394564.1 Reference GRCz11 ALT_DRER_TU_1

      Range
      136712..159740
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_021471569.2 → XP_021327244.1  alpha-L-iduronidase

      UniProtKB/TrEMBL
      A0A8M9PQU4
      Conserved Domains (1) summary
      cl23725
      Location:33 → 538
      Glyco_hydro_1; Glycosyl hydrolase family 1

    Reference GRCz11 ALT_DRER_TU_2

    Genomic

    1. NW_018395234.1 Reference GRCz11 ALT_DRER_TU_2

      Range
      138108..164904
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_021474008.2 → XP_021329683.1  alpha-L-iduronidase

      UniProtKB/TrEMBL
      A0A8M9PRM9
      Conserved Domains (1) summary
      cl23725
      Location:33 → 538
      Glyco_hydro_1; Glycosyl hydrolase family 1
    Nucleotide Protein Strain
    Heading Accession and Version

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