U.S. flag

An official website of the United States government

Links from Protein

    • Showing Current items.

    farp2 FERM, RhoGEF and pleckstrin domain protein 2 [ Danio rerio (zebrafish) ]

    Gene ID: 567490, updated on 9-Dec-2024

    Summary

    Official Symbol
    farp2provided by ZNC
    Official Full Name
    FERM, RhoGEF and pleckstrin domain protein 2provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-2993
    See related
    Ensembl:ENSDARG00000016429 AllianceGenome:ZFIN:ZDB-GENE-030131-2993
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    Runx2a; wu:fc23d05; wu:fp25d09
    Summary
    Predicted to enable guanyl-nucleotide exchange factor activity. Predicted to be located in cytoskeleton. Orthologous to human FARP2 (FERM, ARH/RhoGEF and pleckstrin domain protein 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See farp2 in Genome Data Viewer
    Location:
    chromosome: 6
    Exon count:
    29
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 6 NC_007117.7 (26948128..27038629)
    105 previous assembly GRCz10 (GCF_000002035.5) 6 NC_007117.6 (26957534..27048070)

    Chromosome 6 - NC_007117.7Genomic Context describing neighboring genes Neighboring gene high density lipoprotein binding protein a Neighboring gene ephexin-1 Neighboring gene serine/threonine kinase 25a Neighboring gene BCL2 family apoptosis regulator BOK a

    Genomic regions, transcripts, and products

    Expression

    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    General gene information

    Gene Ontology Provided by ZFIN

    Component Evidence Code Pubs
    located_in cytoskeleton  

    General protein information

    Preferred Names
    FERM, RhoGEF and pleckstrin domain-containing protein 2; FERM, ARHGEF and pleckstrin domain-containing protein 2
    Names
    Runx2a splice form 5

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007117.7 Reference GRCz11 Primary Assembly

      Range
      26948128..27038629
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_009302421.3 → XP_009300696.1  FERM, ARHGEF and pleckstrin domain-containing protein 2 isoform X1

      UniProtKB/TrEMBL
      A0A8M3ATD1, A0A8M9Q6T8
      Conserved Domains (9) summary
      smart00295
      Location:53 → 241
      B41; Band 4.1 homologues
      cd01220
      Location:747 → 861
      PH1_FARP1-like; FERM, RhoGEF and pleckstrin domain-containing protein 1 and related proteins Pleckstrin Homology (PH) domain, repeat 1
      cd13193
      Location:228 → 348
      FERM_C_FARP1-like; FERM domain C-lobe of FERM, RhoGEF and pleckstrin domain-containing protein 1 and related proteins
      cd13235
      Location:933 → 1030
      PH2_FARP1-like; FERM, RhoGEF and pleckstrin domain-containing protein 1 and related proteins Pleckstrin Homology (PH) domain, repeat 2
      pfam00169
      Location:938 → 1031
      PH; PH domain
      pfam00373
      Location:138 → 241
      FERM_M; FERM central domain
      pfam00621
      Location:537 → 720
      RhoGEF; RhoGEF domain
      pfam08736
      Location:341 → 382
      FA; FERM adjacent (FA)
      pfam09379
      Location:55 → 118
      FERM_N; FERM N-terminal domain
    2. XM_021477117.2 → XP_021332792.1  FERM, ARHGEF and pleckstrin domain-containing protein 2 isoform X3

      UniProtKB/TrEMBL
      A0A8M9PMS8, A0A8M9Q6T8
      Conserved Domains (6) summary
      smart00295
      Location:53 → 241
      B41; Band 4.1 homologues
      cd00160
      Location:535 → 722
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd01220
      Location:747 → 861
      PH1_FARP1-like; FERM, RhoGEF and pleckstrin domain-containing protein 1 and related proteins Pleckstrin Homology (PH) domain, repeat 1
      cd13193
      Location:228 → 348
      FERM_C_FARP1-like; FERM domain C-lobe of FERM, RhoGEF and pleckstrin domain-containing protein 1 and related proteins
      cd13235
      Location:925 → 1022
      PH2_FARP1-like; FERM, RhoGEF and pleckstrin domain-containing protein 1 and related proteins Pleckstrin Homology (PH) domain, repeat 2
      pfam08736
      Location:341 → 382
      FA; FERM adjacent (FA)
    3. XM_068221972.1 → XP_068078073.1  FERM, ARHGEF and pleckstrin domain-containing protein 2 isoform X2

      UniProtKB/TrEMBL
      A0A8M9Q6T8, A0A8M9QG07, E7FE33
      Related
      ENSDARP00000129410.1, ENSDART00000153595.3
    4. XM_021477118.2 → XP_021332793.1  FERM, ARHGEF and pleckstrin domain-containing protein 2 isoform X4

      UniProtKB/TrEMBL
      A0A8M9Q0H0, A0A8M9Q6T8
      Conserved Domains (6) summary
      smart00295
      Location:53 → 241
      B41; Band 4.1 homologues
      cd00160
      Location:520 → 707
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd01220
      Location:732 → 846
      PH1_FARP1-like; FERM, RhoGEF and pleckstrin domain-containing protein 1 and related proteins Pleckstrin Homology (PH) domain, repeat 1
      cd13193
      Location:228 → 348
      FERM_C_FARP1-like; FERM domain C-lobe of FERM, RhoGEF and pleckstrin domain-containing protein 1 and related proteins
      cd13235
      Location:918 → 1015
      PH2_FARP1-like; FERM, RhoGEF and pleckstrin domain-containing protein 1 and related proteins Pleckstrin Homology (PH) domain, repeat 2
      pfam08736
      Location:341 → 382
      FA; FERM adjacent (FA)
    5. XM_068221973.1 → XP_068078074.1  FERM, ARHGEF and pleckstrin domain-containing protein 2 isoform X5

      UniProtKB/TrEMBL
      A0A8M9Q6T8
    External link. Please review our privacy policy.