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    Slc25a27 solute carrier family 25, member 27 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 85262, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Slc25a27provided by RGD
    Official Full Name
    solute carrier family 25, member 27provided by RGD
    Primary source
    RGD:620787
    See related
    EnsemblRapid:ENSRNOG00000010592 AllianceGenome:RGD:620787
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Ucp4
    Summary
    Predicted to enable chloride transmembrane transporter activity; protein homodimerization activity; and proton transmembrane transporter activity. Involved in several processes, including intracellular triglyceride homeostasis; negative regulation of mitochondrial calcium ion concentration; and negative regulation of mitochondrial membrane potential. Located in apical part of cell and neuronal cell body. Human ortholog(s) of this gene implicated in schizophrenia. Orthologous to human SLC25A27 (solute carrier family 25 member 27). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 56.5), Testes (RPKM 9.9) and 8 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Slc25a27 in Genome Data Viewer
    Location:
    9q13
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (24804183..24831219)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (17306898..17333942)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (19880468..19907506)

    Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene regulator of calcineurin 2 Neighboring gene uncharacterized LOC120094639 Neighboring gene cytochrome P450, family 39, subfamily a, polypeptide 1 Neighboring gene uncharacterized LOC134480345 Neighboring gene tudor domain containing 6 Neighboring gene phospholipase A2 group VII

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Overexpression of uncoupling protein 4 promotes proliferation and inhibits apoptosis and differentiation of preadipocytes. Zhang M, et al. Life Sci, 2006 Sep 5. PMID 16716360
    2. Domoic acid induced spinal cord lesions in adult mice: evidence for the possible molecular pathways of excitatory amino acids in spinal cord lesions. Xu R, et al. Neurotoxicology, 2008 Jul. PMID 18534681
    3. UCP4 overexpression improves fatty acid oxidation and insulin sensitivity in L6 myocytes. Gao CL, et al. J Bioenerg Biomembr, 2011 Apr. PMID 21607879
    4. Role of mitochondrial uncoupling protein 4 in rat inner ear. Smorodchenko A, et al. Mol Cell Neurosci, 2011 Aug. PMID 21397696
    5. Chronic alcohol consumption increases the expression of uncoupling protein-2 and -4 in the brain. Graw JA, et al. Alcohol Clin Exp Res, 2013 Oct. PMID 23800309

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Silencing of UCP4 in primary chondrocytes significantly inhibited cell survival, but induced reactive oxygen species production and cell apoptosis.
      Title: Effects of UCP4 on the Proliferation and Apoptosis of Chondrocytes: Its Possible Involvement and Regulation in Osteoarthritis.
    2. A compensatory effect was found for UCP-4 (and UCP-2) in the brain during chronic alcohol consumption.
      Title: Chronic alcohol consumption increases the expression of uncoupling protein-2 and -4 in the brain.
    3. After high altitude exposure, UCP-4 mRNA abundance is 2.9-fold compared with the control; UCP-5 mRNA abundance is 2.3-fold compared with the control.
      Title: Evidence for involvement of uncoupling proteins in cerebral mitochondrial oxidative phosphorylation deficiency of rats exposed to 5,000 m high altitude.
    4. Data demonstrate that UCP4 expression is differently regulated during postnatal stages and is region-specific, and may play an important role in functional maturation of the rat inner ear.
      Title: Role of mitochondrial uncoupling protein 4 in rat inner ear.
    5. UCP4 overexpression reduced the insulin sensitivity and mitochondrial fatty acid oxidation of L6 myocytes.
      Title: UCP4 overexpression improves fatty acid oxidation and insulin sensitivity in L6 myocytes.
    6. expression levels are higher in aged female brain as compared to male one
      Title: Sex-dependent differences in aged rat brain mitochondrial function and oxidative stress.
    7. Mitochondrial UCPs (UCP2, UCP3, UCP4) may play both a protective role against oxidative damage and a thermal signaling role in the eighth nerve.
      Title: Localization of the mitochondrial uncoupling protein family in the rat inner ear.
    8. Results suggest that mitochondrial UCP4 mediates an adaptive shift in energy metabolism and increases the resistance of neurons to metabolic and oxidative stress.
      Title: Mitochondrial UCP4 mediates an adaptive shift in energy metabolism and increases the resistance of neurons to metabolic and oxidative stress.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables chloride transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables proton transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in chloride transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in inner ear development IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in intracellular triglyceride homeostasis IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of apoptotic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of mitochondrial calcium ion concentration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of mitochondrial membrane potential IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of neuron apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of cell population proliferation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in proton transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of D-glucose import IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in response to cold IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in apical part of cell IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrial inner membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrial membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in neuronal cell body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    mitochondrial uncoupling protein 4
    Names
    uncoupling protein UCP-4

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_053500.2 → NP_445952.1  mitochondrial uncoupling protein 4

      See identical proteins and their annotated locations for NP_445952.1

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000009
      UniProtKB/TrEMBL
      A6JJ28, A6JJ30, F7F692, Q9EPH7
      Related
      ENSRNOP00000039207.4, ENSRNOT00000052068.5
      Conserved Domains (2) summary
      PTZ00169
      Location:22 → 316
      PTZ00169; ADP/ATP transporter on adenylate translocase; Provisional
      pfam00153
      Location:122 → 218
      Mito_carr; Mitochondrial carrier protein

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086027.1 Reference GRCr8

      Range
      24804183..24831219
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006244610.5 → XP_006244672.1  mitochondrial uncoupling protein 4 isoform X1

      See identical proteins and their annotated locations for XP_006244672.1

      UniProtKB/TrEMBL
      A6JJ28, Q9EPH5
      Conserved Domains (1) summary
      pfam00153
      Location:122 → 218
      Mito_carr; Mitochondrial carrier protein

    2. XM_006244611.5 → XP_006244673.1  mitochondrial uncoupling protein 4 isoform X2

      See identical proteins and their annotated locations for XP_006244673.1

      UniProtKB/TrEMBL
      A0A8I6ALR4, Q9EPH6
      Conserved Domains (1) summary
      pfam00153
      Location:122 → 218
      Mito_carr; Mitochondrial carrier protein

    3. XM_006244612.5 → XP_006244674.1  mitochondrial uncoupling protein 4 isoform X4

      UniProtKB/TrEMBL
      A6JJ28
      Conserved Domains (2) summary
      PTZ00169
      Location:22 → 306
      PTZ00169; ADP/ATP transporter on adenylate translocase; Provisional
      pfam00153
      Location:122 → 218
      Mito_carr; Mitochondrial carrier protein

    4. XM_039084299.2 → XP_038940227.1  mitochondrial uncoupling protein 4 isoform X5

      Conserved Domains (1) summary
      pfam00153
      Location:75 → 171
      Mito_carr; Mitochondrial carrier protein

    5. XM_039084303.2 → XP_038940231.1  mitochondrial uncoupling protein 4 isoform X8

      Conserved Domains (1) summary
      pfam00153
      Location:136 → 232
      Mito_carr; Mitochondrial carrier protein

    6. XM_039084300.2 → XP_038940228.1  mitochondrial uncoupling protein 4 isoform X5

      Conserved Domains (1) summary
      pfam00153
      Location:75 → 171
      Mito_carr; Mitochondrial carrier protein

    7. XM_063267787.1 → XP_063123857.1  mitochondrial uncoupling protein 4 isoform X6

      UniProtKB/TrEMBL
      Q6R5J6
      Related
      ENSRNOP00000094770.2, ENSRNOT00000098372.2

    8. XM_008766882.4 → XP_008765104.2  mitochondrial uncoupling protein 4 isoform X3

      Conserved Domains (1) summary
      pfam00153
      Location:93 → 189
      Mito_carr; Mitochondrial carrier protein

    9. XM_039084302.2 → XP_038940230.1  mitochondrial uncoupling protein 4 isoform X7

      Conserved Domains (1) summary
      pfam00153
      Location:18 → 114
      Mito_carr; Mitochondrial carrier protein
    Nucleotide Protein Strain
    Heading Accession and Version

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