TNKS2 tankyrase 2 [Homo sapiens (human)] - Gene

Summary

Official Symbol: TNKS2provided by HGNC
Official Full Name: tankyrase 2provided by HGNC
Primary source: HGNC:HGNC:15677
See related: Ensembl:ENSG00000107854 MIM:607128; AllianceGenome:HGNC:15677
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: TNKL; ARTD6; TANK2; pART6; PARP5B; PARP5C; PARP-5b; PARP-5c
Summary: Enables NAD+-protein poly-ADP-ribosyltransferase activity and enzyme binding activity. Involved in several processes, including positive regulation of canonical Wnt signaling pathway; post-translational protein modification; and regulation of telomere maintenance. Located in nuclear envelope; pericentriolar material; and perinuclear region of cytoplasm. [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in thyroid (RPKM 15.7), placenta (RPKM 12.5) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 10q23.32

Exon count:: 29

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	10	NC_000010.11 (91798426..91865475)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	10	NC_060934.1 (92681611..92748788)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	10	NC_000010.10 (93558183..93625232)

Chromosome 10 - NC_000010.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Tankyrases inhibit innate antiviral response by PARylating VISA/MAVS and priming it for RNF146-mediated ubiquitination and degradation.
Title: Tankyrases inhibit innate antiviral response by PARylating VISA/MAVS and priming it for RNF146-mediated ubiquitination and degradation.
miR-582-5p inhibits migration and chemo-resistant capabilities of colorectal cancer cells by targeting TNKS2.
Title: miR-582-5p inhibits migration and chemo-resistant capabilities of colorectal cancer cells by targeting TNKS2.
Down-regulation of hsa_circ_0045474 induces macrophage autophagy in tuberculosis via miR-582-5p/TNKS2 axis.
Title: Down-regulation of hsa_circ_0045474 induces macrophage autophagy in tuberculosis via miR-582-5p/TNKS2 axis.
Mapping methylation quantitative trait loci in cardiac tissues nominates risk loci and biological pathways in congenital heart disease.
Title: Mapping methylation quantitative trait loci in cardiac tissues nominates risk loci and biological pathways in congenital heart disease.
PARP5B is required for nonhomologous end joining during tumorigenesis in vivo.
Title: PARP5B is required for nonhomologous end joining during tumorigenesis in vivo.
MicroRNA-206 inhibits influenza A virus replication by targeting tankyrase 2.
Title: MicroRNA-206 inhibits influenza A virus replication by targeting tankyrase 2.
Dissecting the molecular determinants of clinical PARP1 inhibitor selectivity for tankyrase1.
Title: Dissecting the molecular determinants of clinical PARP1 inhibitor selectivity for tankyrase1.
MicroRNA-490-3p inhibits migration and chemoresistance of colorectal cancer cells via targeting TNKS2.
Title: MicroRNA-490-3p inhibits migration and chemoresistance of colorectal cancer cells via targeting TNKS2.
Arpin Regulates Migration Persistence by Interacting with Both Tankyrases and the Arp2/3 Complex.
Title: Arpin Regulates Migration Persistence by Interacting with Both Tankyrases and the Arp2/3 Complex.
Association of Relative Leucocyte Telomere Length and Gene Single Nucleotide Polymorphisms (TERT, TRF1, TNKS2) in Laryngeal Squamous Cell Carcinoma.
Title: Association of Relative Leucocyte Telomere Length and Gene Single Nucleotide Polymorphisms (TERT, TRF1, TNKS2) in Laryngeal Squamous Cell Carcinoma.

Submit: New GeneRIF Correction See all GeneRIFs (37)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

WI-16054 (e-PCR)
- UniSTS:83507

D10S2170 (e-PCR)
- UniSTS:3728

NIB351 (e-PCR)
- UniSTS:49817

RH78232 (e-PCR)
- UniSTS:88737

R58932 (e-PCR)
- UniSTS:6050

RH45093 (e-PCR)
- UniSTS:21412

RH64715 (e-PCR)
- UniSTS:90811

RH68352 (e-PCR)
- UniSTS:2002

SHGC-53837 (e-PCR)
- UniSTS:16112

HSC0JF072 (e-PCR)
- UniSTS:76796

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables NAD+-histone H2BE18 glutamate ADP-ribosyltransferase activity	IEA Inferred from Electronic Annotation more info
enables NAD+-histone H2BE2 glutamate ADP-ribosyltransferase activity	IEA Inferred from Electronic Annotation more info
enables NAD+-histone H2BE35 glutamate ADP-ribosyltransferase activity	IEA Inferred from Electronic Annotation more info
enables NAD+-protein ADP-ribosyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables NAD+-protein poly-ADP-ribosyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables NAD+-protein poly-ADP-ribosyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables NAD+-protein poly-ADP-ribosyltransferase activity	TAS Traceable Author Statement more info
enables NAD+-protein-aspartate ADP-ribosyltransferase activity	IEA Inferred from Electronic Annotation more info
enables enzyme binding	IPI Inferred from Physical Interaction more info	PubMed
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables nucleotidyltransferase activity	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in Wnt signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of telomere maintenance via telomere lengthening	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of canonical Wnt signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of canonical Wnt signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of canonical Wnt signaling pathway	TAS Traceable Author Statement more info
involved_in positive regulation of telomere capping	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of telomere capping	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of telomere maintenance via telomerase	TAS Traceable Author Statement more info	PubMed
involved_in protein auto-ADP-ribosylation	IDA Inferred from Direct Assay more info	PubMed
involved_in protein localization to chromosome, telomeric region	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein localization to chromosome, telomeric region	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein poly-ADP-ribosylation	IDA Inferred from Direct Assay more info	PubMed
involved_in protein polyubiquitination	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in Golgi membrane	IEA Inferred from Electronic Annotation more info
located_in chromosome, telomeric region	TAS Traceable Author Statement more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	TAS Traceable Author Statement more info
located_in nuclear envelope	IDA Inferred from Direct Assay more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in pericentriolar material	IDA Inferred from Direct Assay more info	PubMed
located_in perinuclear region of cytoplasm	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: poly [ADP-ribose] polymerase tankyrase-2

Names: ADP-ribosyltransferase diphtheria toxin-like 6; TNKS-2; TRF1-interacting ankyrin-related ADP-ribose polymerase 2; poly [ADP-ribose] polymerase 5B; protein poly-ADP-ribosyltransferase tankyrase-2; tankyrase II; tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2; tankyrase-like protein; tankyrase-related protein

NP_079511.1

EC 2.4.2.30

XP_011538515.1

EC 2.4.2.30

XP_016872188.1

EC 2.4.2.30

XP_016872189.2

EC 2.4.2.30

XP_016872190.1

EC 2.4.2.30

XP_047281751.1

EC 2.4.2.30

XP_054222802.1

EC 2.4.2.30

XP_054222803.1

EC 2.4.2.30

XP_054222804.1

EC 2.4.2.30

XP_054222805.1

EC 2.4.2.30

XP_054222806.1

EC 2.4.2.30

XP_054222807.1

EC 2.4.2.30

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_025235.4 → NP_079511.1 poly [ADP-ribose] polymerase tankyrase-2

See identical proteins and their annotated locations for NP_079511.1

Status: VALIDATED

Source sequence(s)

AF309033, AF438201, BQ019749

Consensus CDS

CCDS7417.1

UniProtKB/Swiss-Prot

B2RBD3, Q9H2K2, Q9H8F2, Q9HAS4

UniProtKB/TrEMBL

A0AA34QVI1

Related

ENSP00000360689.4, ENST00000371627.5

Conserved Domains (6) summary

PHA02876
Location:73 → 458

PHA02876; ankyrin repeat protein; Provisional

cd09524
Location:871 → 936

SAM_tankyrase1,2; SAM domain of tankyrase1,2 subfamily

PHA03095
Location:494 → 802

PHA03095; ankyrin-like protein; Provisional

cd01438
Location:938 → 1160

tankyrase_like; Tankyrases interact with the telomere reverse transcriptase complex (TERT). Tankyrase 1 poly-ADP-ribosylates Telomere Repeat Binding Factor 1 (TRF1) while Tankyrase 2 can poly-ADP-ribosylate itself or TRF1. The tankyrases also contain multiple ankyrin ...

sd00045
Location:528 → 556

ANK; ANK repeat [structural motif]

pfam13857
Location:43 → 96

Ank_5; Ankyrin repeats (many copies)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000010.11 Reference GRCh38.p14 Primary Assembly

Range

91798426..91865475

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011540213.2 → XP_011538515.1 poly [ADP-ribose] polymerase tankyrase-2 isoform X1

UniProtKB/TrEMBL

A0AA34QVI1

Conserved Domains (6) summary

PHA02876
Location:94 → 479

PHA02876; ankyrin repeat protein; Provisional

cd09524
Location:892 → 957

SAM_tankyrase1,2; SAM domain of tankyrase1,2 subfamily

PHA03095
Location:515 → 823

PHA03095; ankyrin-like protein; Provisional

cd01438
Location:959 → 1181

tankyrase_like; Tankyrases interact with the telomere reverse transcriptase complex (TERT). Tankyrase 1 poly-ADP-ribosylates Telomere Repeat Binding Factor 1 (TRF1) while Tankyrase 2 can poly-ADP-ribosylate itself or TRF1. The tankyrases also contain multiple ankyrin ...

sd00045
Location:549 → 577

ANK; ANK repeat [structural motif]

pfam12796
Location:28 → 142

Ank_2; Ankyrin repeats (3 copies)
XM_017016701.2 → XP_016872190.1 poly [ADP-ribose] polymerase tankyrase-2 isoform X4

Conserved Domains (3) summary

PHA02876
Location:94 → 479

PHA02876; ankyrin repeat protein; Provisional

sd00045
Location:234 → 262

ANK; ANK repeat [structural motif]

pfam12796
Location:28 → 142

Ank_2; Ankyrin repeats (3 copies)
XM_047425795.1 → XP_047281751.1 poly [ADP-ribose] polymerase tankyrase-2 isoform X5
XM_017016699.2 → XP_016872188.1 poly [ADP-ribose] polymerase tankyrase-2 isoform X2

UniProtKB/TrEMBL

A0AA34QVI1

Conserved Domains (5) summary

cd09524
Location:764 → 829

SAM_tankyrase1,2; SAM domain of tankyrase1,2 subfamily

PHA03095
Location:387 → 695

PHA03095; ankyrin-like protein; Provisional

cd01438
Location:831 → 1053

tankyrase_like; Tankyrases interact with the telomere reverse transcriptase complex (TERT). Tankyrase 1 poly-ADP-ribosylates Telomere Repeat Binding Factor 1 (TRF1) while Tankyrase 2 can poly-ADP-ribosylate itself or TRF1. The tankyrases also contain multiple ankyrin ...

sd00045
Location:421 → 449

ANK; ANK repeat [structural motif]

cl39094
Location:100 → 365

Ank_2; Ankyrin repeats (3 copies)
XM_017016700.3 → XP_016872189.2 poly [ADP-ribose] polymerase tankyrase-2 isoform X3

Alternate T2T-CHM13v2.0

Genomic

NC_060934.1 Alternate T2T-CHM13v2.0

Range

92681611..92748788

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054366827.1 → XP_054222802.1 poly [ADP-ribose] polymerase tankyrase-2 isoform X1
XM_054366830.1 → XP_054222805.1 poly [ADP-ribose] polymerase tankyrase-2 isoform X4
XM_054366831.1 → XP_054222806.1 poly [ADP-ribose] polymerase tankyrase-2 isoform X5
XM_054366828.1 → XP_054222803.1 poly [ADP-ribose] polymerase tankyrase-2 isoform X2
XM_054366832.1 → XP_054222807.1 poly [ADP-ribose] polymerase tankyrase-2 isoform X6
XM_054366829.1 → XP_054222804.1 poly [ADP-ribose] polymerase tankyrase-2 isoform X3