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    Oat ornithine aminotransferase [ Rattus norvegicus (Norway rat) ]

    Gene ID: 64313, updated on 9-Dec-2024

    Summary

    Official Symbol
    Oatprovided by RGD
    Official Full Name
    ornithine aminotransferaseprovided by RGD
    Primary source
    RGD:621724
    See related
    EnsemblRapid:ENSRNOG00000016807 AllianceGenome:RGD:621724
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    rOAT
    Summary
    Predicted to enable identical protein binding activity; ornithine aminotransferase activity; and pyridoxal phosphate binding activity. Predicted to be involved in arginine catabolic process to glutamate and arginine catabolic process to proline via ornithine. Predicted to be located in mitochondrial matrix and nucleoplasm. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in gyrate atrophy. Orthologous to human OAT (ornithine aminotransferase). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 4521.5), Liver (RPKM 1062.7) and 5 other tissues See more
    Orthologs
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    Genomic context

    See Oat in Genome Data Viewer
    Location:
    1q41
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (196777973..196797754, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (187347862..187367644, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (204562289..204582070, complement)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene 60S ribosomal protein L27 pseudogene Neighboring gene cofilin 1, pseudogene 5 Neighboring gene NK1 homeobox 2 Neighboring gene phospholysine phosphohistidine inorganic pyrophosphate phosphatase Neighboring gene uncharacterized LOC120099944

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity TAS
    Traceable Author Statement
    more info
    PubMed 
    enables identical protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables identical protein binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables ornithine aminotransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables ornithine aminotransferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables ornithine aminotransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables pyridoxal phosphate binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Process Evidence Code Pubs
    involved_in L-proline biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in arginine catabolic process to glutamate IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in arginine catabolic process to proline via ornithine IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in ornithine metabolic process TAS
    Traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in mitochondrial matrix ISO
    Inferred from Sequence Orthology
    more info
     
    located_in mitochondrial matrix ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    ornithine aminotransferase, mitochondrial
    Names
    ornithine aminotransferase (gyrate atrophy)
    ornithine--oxo-acid aminotransferase
    NP_071966.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_022521.3NP_071966.1  ornithine aminotransferase, mitochondrial precursor

      See identical proteins and their annotated locations for NP_071966.1

      Status: PROVISIONAL

      Source sequence(s)
      BC061551
      UniProtKB/Swiss-Prot
      P04182, Q6LDF6, Q6LDF7
      UniProtKB/TrEMBL
      A6HWY7
      Related
      ENSRNOP00000022628.3, ENSRNOT00000022628.7
      Conserved Domains (1) summary
      TIGR01885
      Location:40437
      Orn_aminotrans; ornithine aminotransferase

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      196777973..196797754 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)