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    FPR3 formyl peptide receptor 3 [ Homo sapiens (human) ]

    Gene ID: 2359, updated on 10-Dec-2024

    Summary

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    Official Symbol
    FPR3provided by HGNC
    Official Full Name
    formyl peptide receptor 3provided by HGNC
    Primary source
    HGNC:HGNC:3828
    See related
    Ensembl:ENSG00000187474 MIM:136539; AllianceGenome:HGNC:3828
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    FMLPY; FPRH1; FPRH2; FPRL2; RMLP-R-I; FMLP-R-II; FML2_HUMAN
    Summary
    Predicted to enable N-formyl peptide receptor activity and complement receptor activity. Predicted to be involved in several processes, including complement receptor mediated signaling pathway; phospholipase C-activating G protein-coupled receptor signaling pathway; and positive regulation of cytosolic calcium ion concentration. Predicted to act upstream of or within G protein-coupled receptor signaling pathway. Predicted to be located in membrane. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in appendix (RPKM 15.7), gall bladder (RPKM 12.8) and 22 other tissues See more
    Orthologs
    all
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    Genomic context

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    See FPR3 in Genome Data Viewer
    Location:
    19q13.41
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (51795157..51826190)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (54882351..54913384)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (52298410..52329443)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene formyl peptide receptor 2 Neighboring gene Sharpr-MPRA regulatory region 3543 Neighboring gene uncharacterized LOC105372448 Neighboring gene zinc finger protein 577 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr19:52350575-52351774 Neighboring gene zinc finger protein 84 pseudogene Neighboring gene vomeronasal 1 receptor 98 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. FPR3 reprograms glycolytic metabolism and stemness in gastric cancer via calcium-NFATc1 pathway. Wang L, et al. Cancer Lett, 2024 Jul 1. PMID 38614385
    2. D-Peptide analogues of Boc-Phe-Leu-Phe-Leu-Phe-COOH induce neovascularization via endothelial N-formyl peptide receptor 3. Nawaz MI, et al. Angiogenesis, 2020 Aug. PMID 32152757
    3. The synthetic peptide Trp-Lys-Tyr-Met-Val-Met-NH2 specifically activates neutrophils through FPRL1/lipoxin A4 receptors and is an agonist for the orphan monocyte-expressed chemoattractant receptor FPRL2. Christophe T, et al. J Biol Chem, 2001 Jun 15. PMID 11285256
    4. Human dendritic cells express functional formyl peptide receptor-like-2 (FPRL2) throughout maturation. Yang D, et al. J Leukoc Biol, 2002 Sep. PMID 12223529
    5. Evaluation of cell-free expression system for the production of soluble and functional human GPCR N-formyl peptide receptors. Wang X, et al. Protein Pept Lett, 2013 Nov. PMID 23746112

    See all (31) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. FPR3 reprograms glycolytic metabolism and stemness in gastric cancer via calcium-NFATc1 pathway.
      Title: FPR3 reprograms glycolytic metabolism and stemness in gastric cancer via calcium-NFATc1 pathway.
    2. Formyl peptide receptor 2 is an emerging modulator of inflammation in the liver.
      Title: Formyl peptide receptor 2 is an emerging modulator of inflammation in the liver.
    3. D-Peptide analogues of Boc-Phe-Leu-Phe-Leu-Phe-COOH induce neovascularization via endothelial N-formyl peptide receptor 3.
      Title: D-Peptide analogues of Boc-Phe-Leu-Phe-Leu-Phe-COOH induce neovascularization via endothelial N-formyl peptide receptor 3.
    4. Low FPR3 expression is associated with obstructive sleep apnea.
      Title: Formyl peptide receptor 1 up-regulation and formyl peptide receptor 2/3 down-regulation of blood immune cells along with defective lipoxin A4/resolvin D1 production in obstructive sleep apnea patients.
    5. These findings provide evidence for defective FPR2/3 and annexin A1 expressions that, associated with decreased M2a polarization, might be involved in the development of cigarette smoking induced persistent airflow limitation in chronic obstructive pulmonary disease.
      Title: Defective formyl peptide receptor 2/3 and annexin A1 expressions associated with M2a polarization of blood immune cells in patients with chronic obstructive pulmonary disease.
    6. Taken together, our results suggest that intracellular FPR in naive CD4 T cells and surface FPRs in activated CD4 T cells might regulate immune responses by regulating CD4 T cell activity.
      Title: Intracellular formyl peptide receptor regulates naïve CD4 T cell migration.
    7. The demonstrated proper folding and functionality of the cell-free produced human FPR3 opens a new avenue for the fast and efficient generation of human FPRs (and even other GPCRs) for structural and functional analysis.
      Title: Evaluation of cell-free expression system for the production of soluble and functional human GPCR N-formyl peptide receptors.
    8. The H. pylori-derived peptide Hp(2-20) stimulated eosinophil migration through the engagement of FPR2 and FPR3, and also induced production of VEGF-A and TGF-beta, two key mediators of tissue remodelling.
      Title: Helicobacter pylori HP(2-20) induces eosinophil activation and accumulation in superficial gastric mucosa and stimulates VEGF-alpha and TGF-beta release by interacting with formyl-peptide receptors.
    9. transcriptional variations of FPR3 occur by an alternative promoter during primate evolution.
      Title: Transcriptional variations mediated by an alternative promoter of the FPR3 gene.
    10. F2L peptide, derived from the processing of nanomolar concentrations of heme-binding protein (HEBP)1, is active on FPR3 and able to induce recruitment of FPR3-expressing monocytes, macrophages, and mouse neutrophils
      Title: Processing of HEBP1 by cathepsin D gives rise to F2L, the agonist of formyl peptide receptor 3.
    Submit: New GeneRIF Correction See all GeneRIFs (21)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Discovery and refinement of loci associated with lipid levels.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables N-formyl peptide receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables complement receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in chemotaxis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in complement receptor mediated signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in inflammatory response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in phospholipase C-activating G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of cytosolic calcium ion concentration IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in signal transduction TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane TAS
    Traceable Author Statement
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
    		  

    General protein information

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    Preferred Names
    N-formyl peptide receptor 3
    Names
    FMLP-related receptor II
    formyl peptide receptor-like 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_002030.5 → NP_002021.3  N-formyl peptide receptor 3

      See identical proteins and their annotated locations for NP_002021.3

      Status: VALIDATED

      Source sequence(s)
      AI301735, AK123030, BC059388, CB996360, DA844883
      Consensus CDS
      CCDS12841.1
      UniProtKB/Swiss-Prot
      P25089
      UniProtKB/TrEMBL
      Q6L5J4
      Related
      ENSP00000341821.3, ENST00000339223.5
      Conserved Domains (2) summary
      cd14964
      Location:29 → 53
      7tm_GPCRs; TM helix 1 [structural motif]
      cl28897
      Location:27 → 313
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

      Range
      51795157..51826190
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011526687.3 → XP_011524989.1  N-formyl peptide receptor 3 isoform X1

      See identical proteins and their annotated locations for XP_011524989.1

      UniProtKB/Swiss-Prot
      P25089
      UniProtKB/TrEMBL
      Q6L5J4
      Related
      ENSP00000470471.1, ENST00000595991.1
      Conserved Domains (2) summary
      cd14964
      Location:29 → 53
      7tm_GPCRs; TM helix 1 [structural motif]
      cl28897
      Location:27 → 313
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060943.1 Alternate T2T-CHM13v2.0

      Range
      54882351..54913384
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054320417.1 → XP_054176392.1  N-formyl peptide receptor 3 isoform X1

      UniProtKB/Swiss-Prot
      P25089
      UniProtKB/TrEMBL
      Q6L5J4
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P25089.2 GenPept UniProtKB/Swiss-Prot:P25089

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