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    PLCE1 phospholipase C epsilon 1 [ Homo sapiens (human) ]

    Gene ID: 51196, updated on 10-Dec-2024

    Summary

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    Official Symbol
    PLCE1provided by HGNC
    Official Full Name
    phospholipase C epsilon 1provided by HGNC
    Primary source
    HGNC:HGNC:17175
    See related
    Ensembl:ENSG00000138193 MIM:608414; AllianceGenome:HGNC:17175
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    PLCE; PPLC; NPHS3
    Summary
    This gene encodes a phospholipase enzyme that catalyzes the hydrolysis of phosphatidylinositol-4,5-bisphosphate to generate two second messengers: inositol 1,4,5-triphosphate (IP3) and diacylglycerol (DAG). These second messengers subsequently regulate various processes affecting cell growth, differentiation, and gene expression. This enzyme is regulated by small monomeric GTPases of the Ras and Rho families and by heterotrimeric G proteins. In addition to its phospholipase C catalytic activity, this enzyme has an N-terminal domain with guanine nucleotide exchange (GEF) activity. Mutations in this gene cause early-onset nephrotic syndrome; characterized by proteinuria, edema, and diffuse mesangial sclerosis or focal and segmental glomerulosclerosis. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Sep 2009]
    Expression
    Broad expression in colon (RPKM 6.3), endometrium (RPKM 5.5) and 21 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See PLCE1 in Genome Data Viewer
    Location:
    10q23.33
    Exon count:
    39
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (93993931..94332823)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (94872907..95211918)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (95753688..96092580)

    Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105378438 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2632 Neighboring gene PIP5K1A and PSMD4 like (pseudogene) Neighboring gene RNY4 pseudogene 26 Neighboring gene uncharacterized LOC107984255 Neighboring gene PLCE1 antisense RNA 2 Neighboring gene histone deacetylase 1 pseudogene 1 Neighboring gene RNA, U6 small nuclear 657, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3787 Neighboring gene PLCE1 antisense RNA 1 Neighboring gene H3K27ac hESC enhancer GRCh37_chr10:96117703-96118368 Neighboring gene H3K27ac hESC enhancer GRCh37_chr10:96118369-96119034 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3788 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2633 Neighboring gene NOC3 like DNA replication regulator Neighboring gene MPRA-validated peak1050 silencer Neighboring gene MED14-independent group 3 enhancer GRCh37_chr10:96140095-96141294 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3789 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2634 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2635 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3790 Neighboring gene TBC1 domain family member 12 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:96304601-96305225 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:96305226-96305850 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:96305851-96306474 Neighboring gene H3K27ac hESC enhancer GRCh37_chr10:96335135-96335636 Neighboring gene H3K27ac hESC enhancer GRCh37_chr10:96335637-96336136 Neighboring gene MPRA-validated peak1052 silencer Neighboring gene helicase, lymphoid specific

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

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    Related articles in PubMed

    1. Comprehensive bioinformation analysis of the miRNA of PLCE1 knockdown in esophageal squamous cell carcinoma. Cui X, et al. Mol Cell Biochem, 2018 May. PMID 29238898
    2. Effects of PLCE1 gene silencing by RNA interference on cell cycling and apoptosis in esophageal carcinoma cells. Zhao L, et al. Asian Pac J Cancer Prev, 2014. PMID 25041015
    3. PLCE1 Promotes Esophageal Cancer Cell Progression by Maintaining the Transcriptional Activity of Snail. Zhai S, et al. Neoplasia, 2017 Mar. PMID 28147304, Free PMC Article
    4. Genetic polymorphism of the phospholipase C epsilon 1 gene and risk of gastric cancer. Liu X, et al. Chin Med J (Engl), 2014. PMID 24985593
    5. PLCE1 polymorphisms and expression combined with serum AFP level predicts survival of HBV-related hepatocellular carcinoma patients after hepatectomy. Liao X, et al. Oncotarget, 2017 Apr 25. PMID 28418898, Free PMC Article

    See all (188) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. PLCepsilon promotes the Warburg effect and tumorigenesis through AKT/GSK3beta/Cdc25a in bladder cancer.
      Title: PLCε promotes the Warburg effect and tumorigenesis through AKT/GSK3β/Cdc25a in bladder cancer.
    2. Phospholipase C epsilon-1 (PLCE1) mediates macrophage activation and protection against tuberculosis.
      Title: Phospholipase C epsilon-1 (PLCƐ1) mediates macrophage activation and protection against tuberculosis.
    3. Copy number variation analysis in 138 families with steroid-resistant nephrotic syndrome identifies causal homozygous deletions in PLCE1 and NPHS2 in two families.
      Title: Copy number variation analysis in 138 families with steroid-resistant nephrotic syndrome identifies causal homozygous deletions in PLCE1 and NPHS2 in two families.
    4. Association between the Missense Variant of PLCE1 and the Risk of Colorectal Cancer.
      Title: Association between the Missense Variant of PLCE1 and the Risk of Colorectal Cancer.
    5. Phospholipase Cepsilon insufficiency causes ascending aortic aneurysm and dissection.
      Title: Phospholipase Cε insufficiency causes ascending aortic aneurysm and dissection.
    6. [Association of GSTP1 and PLCE1 gene polymorphisms with primary esophageal cancer].
      Title: [Association of GSTP1 and PLCE1 gene polymorphisms with primary esophageal cancer].
    7. PLCE1 is a poor prognostic marker and may promote immune escape from osteosarcoma by the CD70-CD27 signaling pathway.
      Title: PLCE1 is a poor prognostic marker and may promote immune escape from osteosarcoma by the CD70-CD27 signaling pathway.
    8. PLCE1 as a diagnostic and prognostic biomarker by promoting the growth and progression of oral squamous cell carcinoma.
      Title: PLCE1 as a diagnostic and prognostic biomarker by promoting the growth and progression of oral squamous cell carcinoma.
    9. A broad clinical spectrum of PLCepsilon1-related kidney disease and intrafamilial variability.
      Title: A broad clinical spectrum of PLCε1-related kidney disease and intrafamilial variability.
    10. The Frequency of Genetic Mutations in Pediatric Patients Diagnosed with Nephrotic Syndrome: A Single-Center Retrospective Study in Saudi Arabia.
      Title: The Frequency of Genetic Mutations in Pediatric Patients Diagnosed with Nephrotic Syndrome: A Single-Center Retrospective Study in Saudi Arabia.
    Submit: New GeneRIF Correction See all GeneRIFs (142)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Associated conditions

    Description Tests
    Nephrotic syndrome, type 3
    MedGen: C1853124 OMIM: 610725 GeneReviews: Genetic Steroid-Resistant Nephrotic Syndrome Overview
    		Compare labs

    EBI GWAS Catalog

    Description
    A shared susceptibility locus in PLCE1 at 10q23 for gastric adenocarcinoma and esophageal squamous cell carcinoma.
    EBI GWAS Catalog
    Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk.
    EBI GWAS Catalog
    Genome-wide association study identifies six new loci influencing pulse pressure and mean arterial pressure.
    EBI GWAS Catalog
    Genome-wide association study identifies susceptibility loci for dengue shock syndrome at MICB and PLCE1.
    EBI GWAS Catalog
    Genome-wide association study identifies three new susceptibility loci for esophageal squamous-cell carcinoma in Chinese populations.
    EBI GWAS Catalog
    Genome-wide association study of personality traits in bipolar patients.
    EBI GWAS Catalog
    Genome-wide association study of smoking behaviours in patients with COPD.
    EBI GWAS Catalog
    GWAS for discovery and replication of genetic loci associated with sudden cardiac arrest in patients with coronary artery disease.
    EBI GWAS Catalog
    Joint analysis of three genome-wide association studies of esophageal squamous cell carcinoma in Chinese populations.
    EBI GWAS Catalog
    Meta-analysis of genome-wide association studies identifies novel loci that influence cupping and the glaucomatous process.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    HIV-1 interactions

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    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env HIV-1 envelope glycoproteins gp120 and gp160 directly and specifically impair the CD3/TcR-mediated activation of phospholipase C (PLC) via the CD4 molecule in uninfected T cells PubMed
    Tat tat Phospholipase C/protein kinase C pathway-dependent phosphorylation of p44/42 and JNK MAP kinases is partially involved in IL-1beta induction by HIV-1 Tat PubMed
    tat HIV-1 Tat induces release of calcium and TNF-alpha production, an effect mediated at least in part by activation of phospholipase C PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ23659, KIAA1516, MGC167842

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables enzyme binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables guanyl-nucleotide exchange factor activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphatidylinositol phospholipase C activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phosphatidylinositol phospholipase C activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables phospholipase C activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables small GTPase binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in Ras protein signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in Ras protein signal transduction IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in calcium-mediated signaling NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in diacylglycerol biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in diacylglycerol biosynthetic process TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in epidermal growth factor receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in epidermal growth factor receptor signaling pathway NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in glomerulus development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in intracellular signal transduction IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in lipid catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in phosphatidylinositol metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in phosphatidylinositol-mediated signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in phospholipase C-activating G protein-coupled receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of lamellipodium assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in release of sequestered calcium ion into cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in lamellipodium IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
    		  

    General protein information

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    Preferred Names
    1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1
    Names
    PLC-epsilon-1
    pancreas-enriched phospholipase C
    phosphoinositide phospholipase C
    phosphoinositide phospholipase C-epsilon-1
    phosphoinositide-specific phospholipase C epsilon-1
    NP_001159451.1
    NP_001275918.1
    NP_057425.3
    XP_006717948.1
    XP_006717951.1
    XP_006717953.1
    XP_011538152.1
    XP_011538153.1
    XP_011538154.1
    XP_016871799.1
    XP_016871800.1
    XP_016871801.1
    XP_047281240.1
    XP_047281241.1
    XP_047281242.1
    XP_047281243.1
    XP_047281244.1
    XP_047281245.1
    XP_047281246.1
    XP_047281247.1
    XP_047281248.1
    XP_047281249.1
    XP_047281250.1
    XP_047281251.1
    XP_047281252.1
    XP_047281253.1
    XP_047281254.1
    XP_047281255.1
    XP_047281256.1
    XP_047281257.1
    XP_047281258.1
    XP_047281259.1
    XP_054221979.1
    XP_054221980.1
    XP_054221981.1
    XP_054221982.1
    XP_054221983.1
    XP_054221984.1
    XP_054221985.1
    XP_054221986.1
    XP_054221987.1
    XP_054221988.1
    XP_054221989.1
    XP_054221990.1
    XP_054221991.1
    XP_054221992.1
    XP_054221993.1
    XP_054221994.1
    XP_054221995.1
    XP_054221996.1
    XP_054221997.1
    XP_054221998.1
    XP_054221999.1
    XP_054222000.1
    XP_054222001.1
    XP_054222002.1
    XP_054222003.1
    XP_054222004.1
    XP_054222005.1
    XP_054222006.1

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_015799.2 RefSeqGene

      Range
      5002..343894
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001165979.2 → NP_001159451.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform 2

      See identical proteins and their annotated locations for NP_001159451.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks two exons and has an additional novel exon at its 5' end, compared to variant 1. These differences produce a unique 5' UTR and cause translation initiation at a novel start codon, compared to variant 1. The encoded protein (isoform 2; also known as PLCepsilon1b) has a shorter and distinct N-terminus, compared to isoform 1.
      Source sequence(s)
      AF170071, AK289852, BC151854, BX491865
      Consensus CDS
      CCDS53555.1
      UniProtKB/TrEMBL
      A0A7I2PPM5
      Related
      ENSP00000501910.1, ENST00000675218.1
      Conserved Domains (6) summary
      cd00275
      Location:1564 → 1676
      C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
      cd01780
      Location:1829 → 1928
      PLC_epsilon_RA; Ubiquitin-like domain of Phosphatidylinositide-specific phospholipase
      cd08596
      Location:1083 → 1525
      PI-PLCc_epsilon; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-epsilon
      PLN02952
      Location:1010 → 1675
      PLN02952; phosphoinositide phospholipase C
      pfam00617
      Location:231 → 405
      RasGEF; RasGEF domain
      pfam09279
      Location:1020 → 1071
      EF-hand_like; Phosphoinositide-specific phospholipase C, efhand-like

    2. NM_001288989.2 → NP_001275918.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform 3

      See identical proteins and their annotated locations for NP_001275918.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) uses an alternate in-frame splice site in the coding region, compared to variant 1. This results in a shorter protein (isoform 3), compared to isoform 1.
      Source sequence(s)
      AL139124, AL355341, AL365510, BC144286, BC151854
      Consensus CDS
      CCDS91304.1
      UniProtKB/TrEMBL
      A0A8I5KVG7, B7ZM61
      Related
      ENSP00000508605.1, ENST00000692396.1
      Conserved Domains (6) summary
      cd00275
      Location:1856 → 1968
      C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
      cd08596
      Location:1375 → 1817
      PI-PLCc_epsilon; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-epsilon
      PLN02952
      Location:1302 → 1967
      PLN02952; phosphoinositide phospholipase C
      pfam00617
      Location:539 → 713
      RasGEF; RasGEF domain
      pfam09279
      Location:1312 → 1363
      EF-hand_like; Phosphoinositide-specific phospholipase C, efhand-like
      cl00155
      Location:2121 → 2220
      UBQ; Ubiquitin-like proteins

    3. NM_016341.4 → NP_057425.3  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform 1

      See identical proteins and their annotated locations for NP_057425.3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1; also known as PLCepsilon1a).
      Source sequence(s)
      AB040949, AF117948, AK074239, AL139124, AL355341, AL365510
      Consensus CDS
      CCDS41552.1
      UniProtKB/Swiss-Prot
      A6NGW0, A6NLA1, A7MBN7, A8K1D7, B9EIJ6, Q1X6H8, Q5VWL4, Q5VWL5, Q9H9X8, Q9HBX6, Q9HC53, Q9P212, Q9UHV3
      UniProtKB/TrEMBL
      A0A8I5KVG7
      Related
      ENSP00000360431.2, ENST00000371380.8
      Conserved Domains (6) summary
      cd08596
      Location:1391 → 1833
      PI-PLCc_epsilon; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-epsilon
      PLN02952
      Location:1318 → 1983
      PLN02952; phosphoinositide phospholipase C
      cd16203
      Location:1198 → 1378
      EFh_PI-PLCepsilon; EF-hand motif found in phosphoinositide phospholipase C epsilon 1 (PI-PLC-epsilon1)
      cd01780
      Location:2134 → 2236
      RA2_PLC-epsilon; Ras-associating (RA) domain 2 found in Phosphatidylinositide-specific phospholipase C (PLC)-epsilon
      cd17229
      Location:2007 → 2114
      RA1_PLC-epsilon; Ras-associating (RA) domain 1 found in Phosphatidylinositide-specific phospholipase C (PLC)-epsilon
      pfam00617
      Location:539 → 713
      RasGEF; RasGEF domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

      Range
      93993931..94332823
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047425285.1 → XP_047281241.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X1

      UniProtKB/TrEMBL
      A0A8I5KVG7

    2. XM_047425289.1 → XP_047281245.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X3

      UniProtKB/Swiss-Prot
      A6NGW0, A6NLA1, A7MBN7, A8K1D7, B9EIJ6, Q1X6H8, Q5VWL4, Q5VWL5, Q9H9X8, Q9HBX6, Q9HC53, Q9P212, Q9UHV3
      UniProtKB/TrEMBL
      A0A8I5KVG7

    3. XM_047425297.1 → XP_047281253.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X5

      UniProtKB/TrEMBL
      A0A8I5KVG7, B7ZM61

    4. XM_047425287.1 → XP_047281243.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X1

      UniProtKB/TrEMBL
      A0A8I5KVG7

    5. XM_017016310.3 → XP_016871799.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X1

      UniProtKB/TrEMBL
      A0A8I5KVG7
      Conserved Domains (6) summary
      cd00275
      Location:1886 → 1998
      C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
      cd08596
      Location:1391 → 1847
      PI-PLCc_epsilon; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-epsilon
      PLN02952
      Location:1318 → 1997
      PLN02952; phosphoinositide phospholipase C
      pfam00617
      Location:539 → 713
      RasGEF; RasGEF domain
      pfam09279
      Location:1328 → 1379
      EF-hand_like; Phosphoinositide-specific phospholipase C, efhand-like
      cl00155
      Location:2151 → 2250
      UBQ; Ubiquitin-like proteins

    6. XM_047425290.1 → XP_047281246.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X3

      UniProtKB/Swiss-Prot
      A6NGW0, A6NLA1, A7MBN7, A8K1D7, B9EIJ6, Q1X6H8, Q5VWL4, Q5VWL5, Q9H9X8, Q9HBX6, Q9HC53, Q9P212, Q9UHV3
      UniProtKB/TrEMBL
      A0A8I5KVG7

    7. XM_047425286.1 → XP_047281242.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X1

      UniProtKB/TrEMBL
      A0A8I5KVG7

    8. XM_006717885.5 → XP_006717948.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X1

      See identical proteins and their annotated locations for XP_006717948.1

      UniProtKB/TrEMBL
      A0A8I5KVG7
      Conserved Domains (6) summary
      cd00275
      Location:1886 → 1998
      C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
      cd08596
      Location:1391 → 1847
      PI-PLCc_epsilon; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-epsilon
      PLN02952
      Location:1318 → 1997
      PLN02952; phosphoinositide phospholipase C
      pfam00617
      Location:539 → 713
      RasGEF; RasGEF domain
      pfam09279
      Location:1328 → 1379
      EF-hand_like; Phosphoinositide-specific phospholipase C, efhand-like
      cl00155
      Location:2151 → 2250
      UBQ; Ubiquitin-like proteins

    9. XM_006717888.5 → XP_006717951.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X2

      UniProtKB/TrEMBL
      A0A8I5KVG7
      Conserved Domains (6) summary
      cd00275
      Location:1885 → 1997
      C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
      cd08596
      Location:1391 → 1846
      PI-PLCc_epsilon; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-epsilon
      PLN02952
      Location:1318 → 1996
      PLN02952; phosphoinositide phospholipase C
      pfam00617
      Location:539 → 713
      RasGEF; RasGEF domain
      pfam09279
      Location:1328 → 1379
      EF-hand_like; Phosphoinositide-specific phospholipase C, efhand-like
      cl00155
      Location:2150 → 2249
      UBQ; Ubiquitin-like proteins

    10. XM_047425284.1 → XP_047281240.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X1

      UniProtKB/TrEMBL
      A0A8I5KVG7

    11. XM_047425291.1 → XP_047281247.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X3

      UniProtKB/Swiss-Prot
      A6NGW0, A6NLA1, A7MBN7, A8K1D7, B9EIJ6, Q1X6H8, Q5VWL4, Q5VWL5, Q9H9X8, Q9HBX6, Q9HC53, Q9P212, Q9UHV3
      UniProtKB/TrEMBL
      A0A8I5KVG7

    12. XM_047425296.1 → XP_047281252.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X4

      UniProtKB/TrEMBL
      A0A8I5KVG7

    13. XM_047425298.1 → XP_047281254.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X5

      UniProtKB/TrEMBL
      A0A8I5KVG7, B7ZM61

    14. XM_047425294.1 → XP_047281250.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X3

      UniProtKB/Swiss-Prot
      A6NGW0, A6NLA1, A7MBN7, A8K1D7, B9EIJ6, Q1X6H8, Q5VWL4, Q5VWL5, Q9H9X8, Q9HBX6, Q9HC53, Q9P212, Q9UHV3
      UniProtKB/TrEMBL
      A0A8I5KVG7

    15. XM_017016311.3 → XP_016871800.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X1

      UniProtKB/TrEMBL
      A0A8I5KVG7
      Conserved Domains (6) summary
      cd00275
      Location:1886 → 1998
      C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
      cd08596
      Location:1391 → 1847
      PI-PLCc_epsilon; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-epsilon
      PLN02952
      Location:1318 → 1997
      PLN02952; phosphoinositide phospholipase C
      pfam00617
      Location:539 → 713
      RasGEF; RasGEF domain
      pfam09279
      Location:1328 → 1379
      EF-hand_like; Phosphoinositide-specific phospholipase C, efhand-like
      cl00155
      Location:2151 → 2250
      UBQ; Ubiquitin-like proteins

    16. XM_047425288.1 → XP_047281244.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X2

      UniProtKB/TrEMBL
      A0A8I5KVG7

    17. XM_047425292.1 → XP_047281248.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X3

      UniProtKB/Swiss-Prot
      A6NGW0, A6NLA1, A7MBN7, A8K1D7, B9EIJ6, Q1X6H8, Q5VWL4, Q5VWL5, Q9H9X8, Q9HBX6, Q9HC53, Q9P212, Q9UHV3
      UniProtKB/TrEMBL
      A0A8I5KVG7

    18. XM_047425293.1 → XP_047281249.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X3

      UniProtKB/Swiss-Prot
      A6NGW0, A6NLA1, A7MBN7, A8K1D7, B9EIJ6, Q1X6H8, Q5VWL4, Q5VWL5, Q9H9X8, Q9HBX6, Q9HC53, Q9P212, Q9UHV3
      UniProtKB/TrEMBL
      A0A8I5KVG7
      Related
      ENSP00000509490.1, ENST00000692286.1

    19. XM_011539851.4 → XP_011538153.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X12

      UniProtKB/TrEMBL
      A0A8I5KV08
      Conserved Domains (3) summary
      pfam00617
      Location:539 → 713
      RasGEF; RasGEF domain
      pfam09279
      Location:1328 → 1379
      EF-hand_like; Phosphoinositide-specific phospholipase C, efhand-like
      cl14615
      Location:1391 → 1530
      PI-PLCc_GDPD_SF; Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily

    20. XM_011539852.4 → XP_011538154.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X13

      UniProtKB/TrEMBL
      A0A8I5KV08
      Related
      ENSP00000508416.1, ENST00000686954.1
      Conserved Domains (3) summary
      pfam00617
      Location:539 → 713
      RasGEF; RasGEF domain
      pfam09279
      Location:1328 → 1379
      EF-hand_like; Phosphoinositide-specific phospholipase C, efhand-like
      cl14615
      Location:1391 → 1530
      PI-PLCc_GDPD_SF; Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily

    21. XM_047425295.1 → XP_047281251.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X4

      UniProtKB/TrEMBL
      A0A8I5KVG7

    22. XM_047425300.1 → XP_047281256.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X5

      UniProtKB/TrEMBL
      A0A8I5KVG7, B7ZM61

    23. XM_047425299.1 → XP_047281255.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X5

      UniProtKB/TrEMBL
      A0A8I5KVG7, B7ZM61

    24. XM_006717890.4 → XP_006717953.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X6

      UniProtKB/TrEMBL
      A0A7I2PPM5
      Conserved Domains (6) summary
      cd00275
      Location:1578 → 1690
      C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
      cd01780
      Location:1843 → 1942
      PLC_epsilon_RA; Ubiquitin-like domain of Phosphatidylinositide-specific phospholipase
      cd08596
      Location:1083 → 1539
      PI-PLCc_epsilon; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-epsilon
      PLN02952
      Location:1010 → 1689
      PLN02952; phosphoinositide phospholipase C
      pfam00617
      Location:231 → 405
      RasGEF; RasGEF domain
      pfam09279
      Location:1020 → 1071
      EF-hand_like; Phosphoinositide-specific phospholipase C, efhand-like

    25. XM_047425302.1 → XP_047281258.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X8

      UniProtKB/TrEMBL
      A0A7I2PPM5

    26. XM_017016312.3 → XP_016871801.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X9

      UniProtKB/TrEMBL
      A0A7I2PPM5, A0A8I5KXT2
      Related
      ENSP00000509140.1, ENST00000688810.1

    27. XM_047425301.1 → XP_047281257.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X7

      UniProtKB/TrEMBL
      A0A7I2PPM5
      Related
      ENSP00000360426.1, ENST00000371375.2

    28. XM_011539850.4 → XP_011538152.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X10

      UniProtKB/TrEMBL
      A0A7I2PPM5
      Conserved Domains (6) summary
      cd00275
      Location:1501 → 1613
      C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
      cd01780
      Location:1766 → 1865
      PLC_epsilon_RA; Ubiquitin-like domain of Phosphatidylinositide-specific phospholipase
      cd08596
      Location:1006 → 1462
      PI-PLCc_epsilon; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-epsilon
      PLN02952
      Location:933 → 1612
      PLN02952; phosphoinositide phospholipase C
      pfam00617
      Location:154 → 328
      RasGEF; RasGEF domain
      pfam09279
      Location:943 → 994
      EF-hand_like; Phosphoinositide-specific phospholipase C, efhand-like

    29. XM_047425303.1 → XP_047281259.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X11

      UniProtKB/TrEMBL
      A0A7I2PPM5

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060934.1 Alternate T2T-CHM13v2.0

      Range
      94872907..95211918
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054366006.1 → XP_054221981.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X1

      UniProtKB/TrEMBL
      A0A8I5KVG7

    2. XM_054366015.1 → XP_054221990.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X3

      UniProtKB/Swiss-Prot
      A6NGW0, A6NLA1, A7MBN7, A8K1D7, B9EIJ6, Q1X6H8, Q5VWL4, Q5VWL5, Q9H9X8, Q9HBX6, Q9HC53, Q9P212, Q9UHV3
      UniProtKB/TrEMBL
      A0A8I5KVG7

    3. XM_054366023.1 → XP_054221998.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X5

      UniProtKB/TrEMBL
      A0A8I5KVG7, B7ZM61

    4. XM_054366016.1 → XP_054221991.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X3

      UniProtKB/Swiss-Prot
      A6NGW0, A6NLA1, A7MBN7, A8K1D7, B9EIJ6, Q1X6H8, Q5VWL4, Q5VWL5, Q9H9X8, Q9HBX6, Q9HC53, Q9P212, Q9UHV3
      UniProtKB/TrEMBL
      A0A8I5KVG7

    5. XM_054366012.1 → XP_054221987.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X3

      UniProtKB/Swiss-Prot
      A6NGW0, A6NLA1, A7MBN7, A8K1D7, B9EIJ6, Q1X6H8, Q5VWL4, Q5VWL5, Q9H9X8, Q9HBX6, Q9HC53, Q9P212, Q9UHV3
      UniProtKB/TrEMBL
      A0A8I5KVG7

    6. XM_054366019.1 → XP_054221994.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X4

      UniProtKB/TrEMBL
      A0A8I5KVG7

    7. XM_054366020.1 → XP_054221995.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X5

      UniProtKB/TrEMBL
      A0A8I5KVG7, B7ZM61

    8. XM_054366008.1 → XP_054221983.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X1

      UniProtKB/TrEMBL
      A0A8I5KVG7

    9. XM_054366009.1 → XP_054221984.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X1

      UniProtKB/TrEMBL
      A0A8I5KVG7

    10. XM_054366013.1 → XP_054221988.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X3

      UniProtKB/Swiss-Prot
      A6NGW0, A6NLA1, A7MBN7, A8K1D7, B9EIJ6, Q1X6H8, Q5VWL4, Q5VWL5, Q9H9X8, Q9HBX6, Q9HC53, Q9P212, Q9UHV3
      UniProtKB/TrEMBL
      A0A8I5KVG7

    11. XM_054366007.1 → XP_054221982.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X1

      UniProtKB/TrEMBL
      A0A8I5KVG7

    12. XM_054366005.1 → XP_054221980.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X1

      UniProtKB/TrEMBL
      A0A8I5KVG7

    13. XM_054366010.1 → XP_054221985.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X2

      UniProtKB/TrEMBL
      A0A8I5KVG7

    14. XM_054366017.1 → XP_054221992.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X3

      UniProtKB/Swiss-Prot
      A6NGW0, A6NLA1, A7MBN7, A8K1D7, B9EIJ6, Q1X6H8, Q5VWL4, Q5VWL5, Q9H9X8, Q9HBX6, Q9HC53, Q9P212, Q9UHV3
      UniProtKB/TrEMBL
      A0A8I5KVG7

    15. XM_054366004.1 → XP_054221979.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X1

      UniProtKB/TrEMBL
      A0A8I5KVG7

    16. XM_054366011.1 → XP_054221986.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X2

      UniProtKB/TrEMBL
      A0A8I5KVG7

    17. XM_054366014.1 → XP_054221989.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X3

      UniProtKB/Swiss-Prot
      A6NGW0, A6NLA1, A7MBN7, A8K1D7, B9EIJ6, Q1X6H8, Q5VWL4, Q5VWL5, Q9H9X8, Q9HBX6, Q9HC53, Q9P212, Q9UHV3
      UniProtKB/TrEMBL
      A0A8I5KVG7

    18. XM_054366030.1 → XP_054222005.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X12

      UniProtKB/TrEMBL
      A0A8I5KV08

    19. XM_054366031.1 → XP_054222006.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X13

      UniProtKB/TrEMBL
      A0A8I5KV08

    20. XM_054366018.1 → XP_054221993.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X4

      UniProtKB/TrEMBL
      A0A8I5KVG7

    21. XM_054366022.1 → XP_054221997.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X5

      UniProtKB/TrEMBL
      A0A8I5KVG7, B7ZM61

    22. XM_054366021.1 → XP_054221996.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X5

      UniProtKB/TrEMBL
      A0A8I5KVG7, B7ZM61

    23. XM_054366028.1 → XP_054222003.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X10

      UniProtKB/TrEMBL
      A0A7I2PPM5

    24. XM_054366029.1 → XP_054222004.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X11

      UniProtKB/TrEMBL
      A0A7I2PPM5

    25. XM_054366024.1 → XP_054221999.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X6

      UniProtKB/TrEMBL
      A0A7I2PPM5

    26. XM_054366026.1 → XP_054222001.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X8

      UniProtKB/TrEMBL
      A0A7I2PPM5

    27. XM_054366027.1 → XP_054222002.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X9

      UniProtKB/TrEMBL
      A0A7I2PPM5, A0A8I5KXT2

    28. XM_054366025.1 → XP_054222000.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X7

      UniProtKB/TrEMBL
      A0A7I2PPM5
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9P212.3 GenPept UniProtKB/Swiss-Prot:Q9P212

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