U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from Protein

    • Showing Current items.

    ncor1 nuclear receptor corepressor 1 [ Danio rerio (zebrafish) ]

    Gene ID: 393246, updated on 4-Jan-2025

    Summary

    Go to the top of the page Help
    Official Symbol
    ncor1provided by ZNC
    Official Full Name
    nuclear receptor corepressor 1provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040426-993
    See related
    Ensembl:ENSDARG00000035285 AllianceGenome:ZFIN:ZDB-GENE-040426-993
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    ncor; zgc:56355
    Summary
    Predicted to enable DNA binding activity. Acts upstream of or within anterior/posterior pattern specification; hindbrain development; and neutrophil differentiation. Predicted to be located in nucleoplasm. Is expressed in several structures, including epidermis; head; liver; pleuroperitoneal region; and ventricular system. Orthologous to human NCOR1 (nuclear receptor corepressor 1). [provided by Alliance of Genome Resources, Jan 2025]
    Orthologs
    human mouse all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See ncor1 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    49
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 5 NC_007116.7 (41878243..41996511, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 5 NC_007116.6 (41278099..41396358, complement)

    Chromosome 5 - NC_007116.7Genomic Context describing neighboring genes Neighboring gene si:dkey-65b12.12 Neighboring gene uncharacterized LOC137495617 Neighboring gene phosphatidylinositol glycan anchor biosynthesis, class L Neighboring gene si:ch211-202a12.4 Neighboring gene centromere protein V

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Corepressor diversification by alternative mRNA splicing is species specific. Privalsky ML, et al. BMC Evol Biol, 2016 Oct 19. PMID 27756201, Free PMC Article
    2. Identification and characterization of a functional zebrafish smrt corepressor (ncor2). Linney E, et al. Gene, 2011 Oct 15. PMID 21767619, Free PMC Article
    3. High-resolution in situ hybridization to whole-mount zebrafish embryos. Thisse C, et al. Nat Protoc, 2008. PMID 18193022
    4. Ncor1 and Ncor2 play essential but distinct roles in zebrafish primitive myelopoiesis. Li J, et al. Dev Dyn, 2014 Dec. PMID 25156564
    5. RNA structural dynamics regulate early embryogenesis through controlling transcriptome fate and function. Shi B, et al. Genome Biol, 2020 May 18. PMID 32423473, Free PMC Article

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Ncor1 and Ncor2 play essential but distinct roles in zebrafish primitive myelopoiesis
      Title: Ncor1 and Ncor2 play essential but distinct roles in zebrafish primitive myelopoiesis.
    Submit: New GeneRIF Correction

    Pathways from PubChem

    Go to the top of the page

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Clone Names

    • MGC56355

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within anterior/posterior pattern specification IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within hindbrain development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within neutrophil differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    nuclear receptor corepressor 1
    Names
    nuclear receptor co-repressor 1

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_200276.2 → NP_956570.2  nuclear receptor corepressor 1

      See identical proteins and their annotated locations for NP_956570.2

      Status: PROVISIONAL

      Source sequence(s)
      EF016488
      UniProtKB/TrEMBL
      A0A8M2BCM0, A8B6H7
      Conserved Domains (3) summary
      smart00717
      Location:641 → 686
      SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
      cd00167
      Location:641 → 684
      SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...
      pfam15784
      Location:141 → 225
      GPS2_interact; G-protein pathway suppressor 2-interacting domain

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007116.7 Reference GRCz11 Primary Assembly

      Range
      41878243..41996511 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_009301627.4 → XP_009299902.1  nuclear receptor corepressor 1 isoform X1

      UniProtKB/TrEMBL
      A0A8M3ASH4, A0A8M3B2M9
      Related
      ENSDARP00000120166.1, ENSDART00000143573.2
      Conserved Domains (3) summary
      smart00717
      Location:641 → 686
      SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
      cd00167
      Location:641 → 684
      SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...
      pfam15784
      Location:141 → 225
      GPS2_interact; G-protein pathway suppressor 2-interacting domain

    2. XM_009301634.4 → XP_009299909.1  nuclear receptor corepressor 1 isoform X4

      UniProtKB/TrEMBL
      A0A8M3AZS8, A0A8M3B2N4
      Conserved Domains (2) summary
      smart00717
      Location:152 → 197
      SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
      cd00167
      Location:152 → 195
      SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...

    3. XM_021476034.2 → XP_021331709.1  nuclear receptor corepressor 1 isoform X2

      UniProtKB/TrEMBL
      A0A8M3AZS8, A0A8M9Q2Z1
      Conserved Domains (1) summary
      smart00717
      Location:157 → 202
      SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains

    4. XM_009301633.4 → XP_009299908.1  nuclear receptor corepressor 1 isoform X3

      UniProtKB/TrEMBL
      A0A8M3ASM4, A0A8M3AZS8
      Related
      ENSDARP00000088345.3, ENSDART00000097574.4
      Conserved Domains (2) summary
      smart00717
      Location:156 → 201
      SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
      cd00167
      Location:156 → 199
      SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...

    Reference GRCz11 ALT_DRER_TU_1

    Genomic

    1. NW_018394603.1 Reference GRCz11 ALT_DRER_TU_1

      Range
      113020..231765 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials
    Tools