yrt yurt [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: yrtprovided by FlyBase
Official Full Name: yurtprovided by FlyBase
Primary source: FLYBASE:FBgn0004049
Locus tag: Dmel_CG9764
See related: AllianceGenome:FB:FBgn0004049
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG9764; dlhB; Dmel\CG9764; l(3)87Ek; l(3)E19; l(3)m112; m112; Nbl4; Yrt; Yurt
Summary: Predicted to enable cytoskeletal protein binding activity. Involved in embryonic development via the syncytial blastoderm; establishment of epithelial cell apical/basal polarity; and eye photoreceptor cell development. Located in apical junction complex; basolateral plasma membrane; and nuclear envelope. Is expressed in larval tracheal system. Orthologous to human EPB41L4B (erythrocyte membrane protein band 4.1 like 4B) and EPB41L5 (erythrocyte membrane protein band 4.1 like 5). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 87E11-87E11; 3-53 cM

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3R	NT_033777.3 (13428867..13434984, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3R	NT_033777.2 (9254589..9260706, complement)

Chromosome 3R - NT_033777.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The polarity protein Yurt associates with the plasma membrane via basic and hydrophobic motifs embedded in its FERM domain.
Title: The polarity protein Yurt associates with the plasma membrane via basic and hydrophobic motifs embedded in its FERM domain.
Oligomerization of the FERM-FA protein Yurt controls epithelial cell polarity.
Title: Oligomerization of the FERM-FA protein Yurt controls epithelial cell polarity.
Results found that Yurt distribution at the subapical region depends on Crb. In contrast to previous reports, yurt mutants phenocopy crb junctional defects. Moreover, while unaffected in crb mutants, cell perimeter increases in yurt mutant cells and decreases in the absence of moesin function.
Title: Crumbs, Moesin and Yurt regulate junctional stability and dynamics for a proper morphogenesis of the Drosophila pupal wing epithelium.
Drosophila FERM proteins Yurt (Yrt) and Coracle (Cora) and the membrane proteins Neurexin IV (Nrx-IV) and Na(+),K(+)-ATPase are a new group of functionally cooperating epithelial polarity proteins
Title: Yurt, Coracle, Neurexin IV and the Na(+),K(+)-ATPase form a novel group of epithelial polarity proteins.
Protein 4.1 family member that is associated with the plasma membrane of epithelial cells.
Title: Drosophila Yurt is a new protein-4.1-like protein required for epithelial morphogenesis.
We propose that Yurt is part of an evolutionary conserved negative-feedback mechanism that restricts Crb complex activity in promoting apical membrane formation.
Title: The FERM protein Yurt is a negative regulatory component of the Crumbs complex that controls epithelial polarity and apical membrane size.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables cytoskeletal protein binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in actomyosin structure organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in amnioserosa maintenance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in dorsal closure	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in establishment of epithelial cell apical/basal polarity	IGI Inferred from Genetic Interaction more info	PubMed
involved_in establishment or maintenance of apical/basal cell polarity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in eye photoreceptor cell development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in germ-band shortening	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in head involution	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in basolateral plasma membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytoskeleton	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
located_in nuclear envelope	IDA Inferred from Direct Assay more info	PubMed
located_in septate junction	IDA Inferred from Direct Assay more info	PubMed
located_in zonula adherens	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: yurt

Names: CG9764-PA; CG9764-PB; CG9764-PC; CG9764-PD; dorsal holes B; lethal(3)87Ek; yrt-PA; yrt-PB; yrt-PC; yrt-PD

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033777.3 Reference assembly

Range

13428867..13434984 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001144572.2 → NP_001138044.1 yurt, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001138044.1

Status: REVIEWED

UniProtKB/TrEMBL

A0T1Z4

Conserved Domains (6) summary

PHA03255
Location:731 → 884

PHA03255; BDLF3; Provisional

smart00295
Location:60 → 250

B41; Band 4.1 homologues

cd13186
Location:246 → 339

FERM_C_NBL4_NBL5; FERM domain C-lobe of Novel band 4.1-like protein 4 and 5 (NBL4 and 5)

pfam00373
Location:143 → 250

FERM_M; FERM central domain

pfam08736
Location:352 → 392

FA; FERM adjacent (FA)

pfam09379
Location:62 → 124

FERM_N; FERM N-terminal domain
NM_001144573.2 → NP_001138045.1 yurt, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001138045.1

Status: REVIEWED

UniProtKB/TrEMBL

A0T1Z5

Conserved Domains (5) summary

smart00295
Location:60 → 250

B41; Band 4.1 homologues

cd13186
Location:246 → 339

FERM_C_NBL4_NBL5; FERM domain C-lobe of Novel band 4.1-like protein 4 and 5 (NBL4 and 5)

pfam00373
Location:143 → 250

FERM_M; FERM central domain

pfam08736
Location:352 → 392

FA; FERM adjacent (FA)

pfam09379
Location:62 → 124

FERM_N; FERM N-terminal domain
NM_142034.2 → NP_650291.1 yurt, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_650291.1

Status: REVIEWED

UniProtKB/TrEMBL

Q9VFU8

Related

FBpp0082261

Conserved Domains (6) summary

PHA03255
Location:771 → 924

PHA03255; BDLF3; Provisional

smart00295
Location:60 → 250

B41; Band 4.1 homologues

cd13186
Location:246 → 339

FERM_C_NBL4_NBL5; FERM domain C-lobe of Novel band 4.1-like protein 4 and 5 (NBL4 and 5)

pfam00373
Location:143 → 250

FERM_M; FERM central domain

pfam08736
Location:352 → 392

FA; FERM adjacent (FA)

pfam09379
Location:62 → 124

FERM_N; FERM N-terminal domain
NM_001144574.2 → NP_001138046.1 yurt, isoform D [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001138046.1

Status: REVIEWED

UniProtKB/TrEMBL

B7Z0J2

Conserved Domains (6) summary

PHA03255
Location:771 → 918

PHA03255; BDLF3; Provisional

smart00295
Location:60 → 250

B41; Band 4.1 homologues

cd13186
Location:246 → 339

FERM_C_NBL4_NBL5; FERM domain C-lobe of Novel band 4.1-like protein 4 and 5 (NBL4 and 5)

pfam00373
Location:143 → 250

FERM_M; FERM central domain

pfam08736
Location:352 → 392

FA; FERM adjacent (FA)

pfam09379
Location:62 → 124

FERM_N; FERM N-terminal domain