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    AZGP1 alpha-2-glycoprotein 1, zinc-binding [ Homo sapiens (human) ]

    Gene ID: 563, updated on 27-Nov-2024

    Summary

    Official Symbol
    AZGP1provided by HGNC
    Official Full Name
    alpha-2-glycoprotein 1, zinc-bindingprovided by HGNC
    Primary source
    HGNC:HGNC:910
    See related
    Ensembl:ENSG00000160862 MIM:194460; AllianceGenome:HGNC:910
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ZAG; ZA2G
    Summary
    Involved in cell adhesion and detection of chemical stimulus involved in sensory perception of bitter taste. Located in extracellular space. Implicated in prostate carcinoma. Biomarker of several diseases, including gastrointestinal system cancer (multiple); kidney failure (multiple); liver cirrhosis; lung adenocarcinoma; and obesity. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in salivary gland (RPKM 748.1), liver (RPKM 688.6) and 5 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See AZGP1 in Genome Data Viewer
    Location:
    7q22.1
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (99966730..99976031, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (101206237..101220128, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (99564353..99573654, complement)

    Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC101927610 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:99526456-99527041 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:99527042-99527626 Neighboring gene gap junction protein gamma 3 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:99541581-99542436 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:99543294-99544149 Neighboring gene small nucleolar RNA SNORA40 Neighboring gene ReSE screen-validated silencer GRCh37_chr7:99580686-99580841 Neighboring gene AZGP1 pseudogene 1 Neighboring gene gap junction protein gamma 3 pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables RNA nuclease activity NAS
    Non-traceable Author Statement
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein transmembrane transporter activity NAS
    Non-traceable Author Statement
    more info
    PubMed 

    General protein information

    Preferred Names
    zinc-alpha-2-glycoprotein
    Names
    Alpha-2-glycoprotein, zinc
    Zn-alpha2-glycoprotein
    testicular tissue protein Li 227
    zn-alpha-2-GP
    zn-alpha-2-glycoprotein

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001185.4NP_001176.1  zinc-alpha-2-glycoprotein precursor

      See identical proteins and their annotated locations for NP_001176.1

      Status: VALIDATED

      Source sequence(s)
      BC005306, BC033830
      Consensus CDS
      CCDS5680.1
      UniProtKB/Swiss-Prot
      D6W5T8, O60386, P25311, Q5XKQ4, Q8N4N0
      UniProtKB/TrEMBL
      A0A140VK00
      Related
      ENSP00000292401.4, ENST00000292401.9
      Conserved Domains (2) summary
      cd07698
      Location:205296
      IgC_MHC_I_alpha3; Class I major histocompatibility complex (MHC) alpha chain immunoglobulin domain
      pfam00129
      Location:26201
      MHC_I; Class I Histocompatibility antigen, domains alpha 1 and 2

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

      Range
      99966730..99976031 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060931.1 Alternate T2T-CHM13v2.0

      Range
      101206237..101220128 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054358658.1XP_054214633.1  zinc-alpha-2-glycoprotein isoform X1

      UniProtKB/Swiss-Prot
      D6W5T8, O60386, P25311, Q5XKQ4, Q8N4N0
      UniProtKB/TrEMBL
      A0A140VK00
    2. XM_054358657.1XP_054214632.1  zinc-alpha-2-glycoprotein isoform X1

      UniProtKB/Swiss-Prot
      D6W5T8, O60386, P25311, Q5XKQ4, Q8N4N0
      UniProtKB/TrEMBL
      A0A140VK00