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    Plin1 perilipin 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 25629, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Plin1provided by RGD
    Official Full Name
    perilipin 1provided by RGD
    Primary source
    RGD:3351
    See related
    EnsemblRapid:ENSRNOG00000015086 AllianceGenome:RGD:3351
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Plin; PERIA
    Summary
    Predicted to be involved in negative regulation of lipid catabolic process. Predicted to act upstream of or within cellular response to cold and lipid catabolic process. Located in lipid droplet. Human ortholog(s) of this gene implicated in familial partial lipodystrophy type 4 and obesity. Orthologous to human PLIN1 (perilipin 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Adrenal (RPKM 331.7), Thymus (RPKM 302.0) and 5 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Plin1 in Genome Data Viewer
    Location:
    1q31
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (143073612..143086199, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (133664294..133676854, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (141458907..141470927, complement)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene kinesin family member 7 Neighboring gene peptidyl-prolyl cis-trans isomerase NIMA-interacting 4-like Neighboring gene uncharacterized LOC120099868 Neighboring gene peroxisomal biogenesis factor 11 alpha Neighboring gene WD repeat domain 93 Neighboring gene small nuclear ribonucleoprotein polypeptide E like 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Serum amyloid A induces lipolysis by downregulating perilipin through ERK1/2 and PKA signaling pathways. Liu LR, et al. Obesity (Silver Spring), 2011 Dec. PMID 21701568
    2. Isolation of cDNAs for perilipins A and B: sequence and expression of lipid droplet-associated proteins of adipocytes. Greenberg AS, et al. Proc Natl Acad Sci U S A, 1993 Dec 15. PMID 7505452, Free PMC Article
    3. Heat shock protein 70 is translocated to lipid droplets in rat adipocytes upon heat stimulation. Jiang H, et al. Biochim Biophys Acta, 2007 Jan. PMID 17175194
    4. Obese subjects carrying the 11482G>A polymorphism at the perilipin locus are resistant to weight loss after dietary energy restriction. Corella D, et al. J Clin Endocrinol Metab, 2005 Sep. PMID 15985482
    5. Perilipin ablation results in a lean mouse with aberrant adipocyte lipolysis, enhanced leptin production, and resistance to diet-induced obesity. Tansey JT, et al. Proc Natl Acad Sci U S A, 2001 May 22. PMID 11371650, Free PMC Article

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. evidence is presented for perilipin expression in rat, mouse, and human islets of Langerhans
      Title: Perilipin is present in islets of Langerhans and protects against lipotoxicity when overexpressed in the beta-cell line INS-1.
    2. perilipin interacts with CGI-58 and is localized to lipid droplets
      Title: CGI-58 interacts with perilipin and is localized to lipid droplets. Possible involvement of CGI-58 mislocalization in Chanarin-Dorfman syndrome.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in cellular response to cold IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within cellular response to cold ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in lipid catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within lipid catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of lipid catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cell periphery ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in lipid droplet IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in lipid droplet IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in lipid droplet ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in lipid droplet TAS
    Traceable Author Statement
    more info
    		  

    General protein information

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    Preferred Names
    perilipin-1
    Names
    PERI
    lipid droplet-associated protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001308145.1 → NP_001295074.1  perilipin-1

      See identical proteins and their annotated locations for NP_001295074.1

      Status: VALIDATED

      Source sequence(s)
      BU671441, FM042626, FM044716, JAXUCZ010000001
      UniProtKB/Swiss-Prot
      P43884
      UniProtKB/TrEMBL
      A6JC64, F1LSF5
      Related
      ENSRNOP00000061809.5, ENSRNOT00000065759.5
      Conserved Domains (1) summary
      pfam03036
      Location:14 → 392
      Perilipin; Perilipin family

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      143073612..143086199 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_008759499.4 → XP_008757721.1  perilipin-1 isoform X1

      See identical proteins and their annotated locations for XP_008757721.1

      UniProtKB/Swiss-Prot
      P43884
      UniProtKB/TrEMBL
      A6JC64, F1LSF5
      Conserved Domains (1) summary
      pfam03036
      Location:14 → 392
      Perilipin; Perilipin family

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_013094.1: Suppressed sequence

      Description
      NM_013094.1: This RefSeq was removed because currently there is insufficient support for the transcript.
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P43884.1 GenPept UniProtKB/Swiss-Prot:P43884

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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