Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Cyp1a2provided by MGI
Official Full Name: cytochrome P450, family 1, subfamily a, polypeptide 2provided by MGI
Primary source: MGI:MGI:88589
See related: Ensembl:ENSMUSG00000032310 AllianceGenome:MGI:88589
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: CP12; CYPIA2; P450-3
Summary: Enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen. Acts upstream of or within several processes, including cellular response to cadmium ion; dibenzo-p-dioxin metabolic process; and hydrogen peroxide biosynthetic process. Predicted to be located in endoplasmic reticulum membrane. Predicted to be active in intracellular membrane-bounded organelle. Is expressed in liver. Human ortholog(s) of this gene implicated in breast cancer; chronic obstructive pulmonary disease; endometrial cancer; and porphyria cutanea tarda. Orthologous to human CYP1A2 (cytochrome P450 family 1 subfamily A member 2). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Restricted expression toward liver adult (RPKM 378.7) See more
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Genomic context

Location:: 9 B; 9 31.3 cM

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	9	NC_000075.7 (57584220..57590938, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	9	NC_000075.6 (57676937..57683655, complement)

Chromosome 9 - NC_000075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Constitutive androstane receptor-responsive elements for mouse Cyp1a2 transcriptional activation induced by constitutive androstane receptor ligands.
Title: Constitutive androstane receptor-responsive elements for mouse Cyp1a2 transcriptional activation induced by constitutive androstane receptor ligands.
Circadian oscillator NPAS2 regulates diurnal expression and activity of CYP1A2 in mouse liver.
Title: Circadian oscillator NPAS2 regulates diurnal expression and activity of CYP1A2 in mouse liver.
Its mRNA expression is decreased by the high level of MRSA, but the low level of MRSA increased its expression.
Title: Effects of infection of MRSA on the expression and activity of renal cytochrome P450s in mice.
results demonstrate that 2,3,4',5-tetrahydroxystilbene-2-O-beta-D-glucoside enhances hepatic expression of CYP3A4, CYP2E1 and CYP1A2, and thus exacerbates the hepatotoxicity induced by acetaminophen in mice.
Title: 2,3,4',5-tetrahydroxystilbene-2-O-β-D-glucoside exacerbates acetaminophen-induced hepatotoxicity by inducing hepatic expression of CYP2E1, CYP3A4 and CYP1A2.
Distribution of parent PCB congeners also varied by genotype with strikingly high levels of PCB 77 in poor-affinity Ahr (d) Cyp1a2(-/-) while Ahr (b) Cyp1a2(+/+) mice effectively sequestered coplanar PCBs in the liver.
Title: Genetic differences in the aryl hydrocarbon receptor and CYP1A2 affect sensitivity to developmental polychlorinated biphenyl exposure in mice: relevance to studies of human neurological disorders.
our results suggest a more important contribution of CYP1A2 to the in vivo plasma clearance and thus detoxification of 4-Aminobiphenyl
Title: Relative Contributions of CYP1A2 and CYP2E1 to the Bioactivation and Clearance of 4-Aminobiphenyl in Adult Mice.
hepatic CYP1A2 plays a critical role in the attenuation of hyperoxic lung injury by decreasing lipid peroxidation and oxidative stress in vivo.
Title: Disruption of cytochrome P4501A2 in mice leads to increased susceptibility to hyperoxic lung injury.
Suggest an important role for CYP1A enzymes in the gender-specific modulation of hyperoxic lung injury.
Title: Sex-specific differences in hyperoxic lung injury in mice: role of cytochrome P450 (CYP)1A.
Aryl hydrocarbon receptor mediated induction of hepatic CYP1A1/1A2 is dependent on the presence of ctnnb1.
Title: Cooperation of structurally different aryl hydrocarbon receptor agonists and β-catenin in the regulation of CYP1A expression.
Results indicate Cyp1a2 genotype is important in susceptibility to PCB-induced deficits in learning and memory.
Title: Ahrd Cyp1a2(-/-) mice show increased susceptibility to PCB-induced developmental neurotoxicity.

Submit: New GeneRIF Correction See all GeneRIFs (28)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (4) 1 citation
Targeted (4) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

PMC291882P1 (e-PCR)
- UniSTS:272440

D9Mit101 (e-PCR), detects polymorphism
- UniSTS:131648

D9Mit101.1 (e-PCR), detects polymorphism
- UniSTS:131649

D9Mit101.2 (e-PCR), detects polymorphism
- UniSTS:131650

Cyp1a2 (e-PCR), detects polymorphism
- UniSTS:462980

Cyp1a2 (e-PCR), detects polymorphism
- UniSTS:141447

Cyp1a2 (e-PCR), detects polymorphism
- UniSTS:141448

D9Mit21 (e-PCR), detects polymorphism
- UniSTS:131765

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables caffeine oxidase activity	IEA Inferred from Electronic Annotation more info
enables caffeine oxidase activity	ISO Inferred from Sequence Orthology more info
enables demethylase activity	IEA Inferred from Electronic Annotation more info
enables demethylase activity	ISO Inferred from Sequence Orthology more info
enables enzyme binding	IEA Inferred from Electronic Annotation more info
enables enzyme binding	ISO Inferred from Sequence Orthology more info
enables estrogen 16-alpha-hydroxylase activity	ISO Inferred from Sequence Orthology more info
enables estrogen 16-alpha-hydroxylase activity	ISS Inferred from Sequence or Structural Similarity more info
enables estrogen 2-hydroxylase activity	ISO Inferred from Sequence Orthology more info
enables estrogen 2-hydroxylase activity	ISS Inferred from Sequence or Structural Similarity more info
enables heme binding	ISO Inferred from Sequence Orthology more info
enables heme binding	ISS Inferred from Sequence or Structural Similarity more info
enables hydroperoxy icosatetraenoate dehydratase activity	IEA Inferred from Electronic Annotation more info
enables iron ion binding	IEA Inferred from Electronic Annotation more info
enables monooxygenase activity	IBA Inferred from Biological aspect of Ancestor more info
enables monooxygenase activity	ISO Inferred from Sequence Orthology more info
enables nitrite reductase (NO-forming) activity	ISO Inferred from Sequence Orthology more info
enables oxidoreductase activity	ISO Inferred from Sequence Orthology more info
enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen	IDA Inferred from Direct Assay more info	PubMed
enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in alkaloid metabolic process	IEA Inferred from Electronic Annotation more info
involved_in alkaloid metabolic process	ISO Inferred from Sequence Orthology more info
involved_in arachidonate metabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cellular respiration	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cellular response to cadmium ion	IDA Inferred from Direct Assay more info	PubMed
involved_in cholesterol metabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within dibenzo-p-dioxin metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in estrogen metabolic process	ISO Inferred from Sequence Orthology more info
involved_in estrogen metabolic process	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within hydrogen peroxide biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within lung development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in monocarboxylic acid metabolic process	ISO Inferred from Sequence Orthology more info
involved_in monoterpenoid metabolic process	IEA Inferred from Electronic Annotation more info
involved_in monoterpenoid metabolic process	ISO Inferred from Sequence Orthology more info
involved_in oxidative demethylation	IEA Inferred from Electronic Annotation more info
involved_in oxidative demethylation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within porphyrin-containing compound metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within post-embryonic development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in retinol metabolic process	IEA Inferred from Electronic Annotation more info
involved_in retinol metabolic process	ISO Inferred from Sequence Orthology more info
involved_in retinol metabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in steroid catabolic process	IEA Inferred from Electronic Annotation more info
involved_in steroid catabolic process	ISO Inferred from Sequence Orthology more info
involved_in toxin biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in toxin biosynthetic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within toxin metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in xenobiotic catabolic process	IEA Inferred from Electronic Annotation more info
involved_in xenobiotic catabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within xenobiotic metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in xenobiotic metabolic process	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
is_active_in intracellular membrane-bounded organelle	IBA Inferred from Biological aspect of Ancestor more info
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: cytochrome P450 1A2

Names: cholesterol 25-hydroxylase; cytochrome P450 family 1 subfamily a polypeptide 1; cytochrome P450, 1a2, aromatic compound inducible; cytochrome P450-P2; cytochrome P450-P3; hydroperoxy icosatetraenoate dehydratase

NP_034123.1

EC 1.14.14.1

EC 4.2.1.152

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.