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    NEK9 NIMA related kinase 9 [ Homo sapiens (human) ]

    Gene ID: 91754, updated on 27-Nov-2024

    Summary

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    Official Symbol
    NEK9provided by HGNC
    Official Full Name
    NIMA related kinase 9provided by HGNC
    Primary source
    HGNC:HGNC:18591
    See related
    Ensembl:ENSG00000119638 MIM:609798; AllianceGenome:HGNC:18591
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    NC; APUG; NERCC; LCCS10; NERCC1
    Summary
    This gene encodes a member of the NimA (never in mitosis A) family of serine/threonine protein kinases. The encoded protein is activated in mitosis and, in turn, activates other family members during mitosis. This protein also mediates cellular processes that are essential for interphase progression. [provided by RefSeq, Jul 2016]
    Expression
    Ubiquitous expression in ovary (RPKM 24.4), testis (RPKM 21.8) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See NEK9 in Genome Data Viewer
    Location:
    14q24.3
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 14 NC_000014.9 (75079353..75127202, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 14 NC_060938.1 (69288752..69338522, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (75546056..75593751, complement)

    Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene RNA, U6 small nuclear 689, pseudogene Neighboring gene mutL homolog 3 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5939 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8735 Neighboring gene H3K27ac hESC enhancer GRCh37_chr14:75535987-75536538 Neighboring gene H3K27ac hESC enhancer GRCh37_chr14:75536539-75537090 Neighboring gene acylphosphatase 1 Neighboring gene zinc finger C2HC-type containing 1C Neighboring gene ReSE screen-validated silencer GRCh37_chr14:75565767-75565964 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8736 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8737 Neighboring gene HIF1AP pseudogene 1 Neighboring gene transmembrane p24 trafficking protein 10 Neighboring gene Sharpr-MPRA regulatory regions 714 and 744 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:75619067-75619731 Neighboring gene H3K27ac hESC enhancer GRCh37_chr14:75643139-75643711 Neighboring gene RNA, U4atac small nuclear 14, pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Somatic Mutations in NEK9 Cause Nevus Comedonicus. Levinsohn JL, et al. Am J Hum Genet, 2016 May 5. PMID 27153399, Free PMC Article
    2. Recognition of host proteins by Helicobacter cysteine-rich protein C. Roschitzki B, et al. Curr Microbiol, 2011 Sep. PMID 21735226
    3. The Dual Nature of Nek9 in Adenovirus Replication. Jung R, et al. J Virol, 2016 Feb 15. PMID 26676776, Free PMC Article
    4. Three novel pathogenic NEK9 variants in patients with nevus comedonicus: A case series. Juratli HA, et al. J Am Acad Dermatol, 2022 Apr. PMID 33819539
    5. NEK9-dependent proliferation of cancer cells lacking functional p53. Kurioka D, et al. Sci Rep, 2014 Aug 18. PMID 25131192, Free PMC Article

    See all (116) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. NIMA-related kinase 9 regulates the phosphorylation of the essential myosin light chain in the heart.
      Title: NIMA-related kinase 9 regulates the phosphorylation of the essential myosin light chain in the heart.
    2. Study on the Expression of lncRNA ATB and Nek9 in Breast Cancer Patients Based on Q-PCR Technology and Its Relationship with the Disease.
      Title: Study on the Expression of lncRNA ATB and Nek9 in Breast Cancer Patients Based on Q-PCR Technology and Its Relationship with the Disease.
    3. Three novel pathogenic NEK9 variants in patients with nevus comedonicus: A case series.
      Title: Three novel pathogenic NEK9 variants in patients with nevus comedonicus: A case series.
    4. NEK9, a novel effector of IL-6/STAT3, regulates metastasis of gastric cancer by targeting ARHGEF2 phosphorylation.
      Title: NEK9, a novel effector of IL-6/STAT3, regulates metastasis of gastric cancer by targeting ARHGEF2 phosphorylation.
    5. The short isoform of PRLR suppresses the pentose phosphate pathway and nucleotide synthesis through the NEK9-Hippo axis in pancreatic cancer.
      Title: The short isoform of PRLR suppresses the pentose phosphate pathway and nucleotide synthesis through the NEK9-Hippo axis in pancreatic cancer.
    6. EML4-ALK V3 oncogenic fusion proteins promote microtubule stabilization and accelerated migration through NEK9 and NEK7.
      Title: EML4-ALK V3 oncogenic fusion proteins promote microtubule stabilization and accelerated migration through NEK9 and NEK7.
    7. Decreased Nek9 expression correlates with aggressive behaviour and predicts unfavourable prognosis in breast cancer.
      Title: Decreased Nek9 expression correlates with aggressive behaviour and predicts unfavourable prognosis in breast cancer.
    8. NIMA-related kinase 9-mediated phosphorylation of the microtubule-associated LC3B protein at Thr-50 suppresses selective autophagy of p62/sequestosome 1.
      Title: NIMA-related kinase 9-mediated phosphorylation of the microtubule-associated LC3B protein at Thr-50 suppresses selective autophagy of p62/sequestosome 1.
    9. This study supports a role for NEK9 and MAP2K4 in mediating buparlisib resistance and demonstrates the value of unbiased omic analyses in uncovering resistance mechanisms to targeted therapy in Triple-Negative Breast Cancers.
      Title: Mass Spectrometry-Based Proteomics Reveals Potential Roles of NEK9 and MAP2K4 in Resistance to PI3K Inhibition in Triple-Negative Breast Cancers.
    10. Eg5 localization and centrosome separation in prophase depend on the nuclear microtubule-associated protein TPX2, a pool of which localizes to the centrosomes before nuclear envelope breakdown. This localization involves the kinase Nek9, which phosphorylates TPX2 nuclear localization signal preventing its interaction with importin and nuclear import.
      Title: Nek9 Phosphorylation Defines a New Role for TPX2 in Eg5-Dependent Centrosome Separation before Nuclear Envelope Breakdown.
    Submit: New GeneRIF Correction See all GeneRIFs (29)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Associated conditions

    Description Tests
    Arthrogryposis, Perthes disease, and upward gaze palsy
    MedGen: C3280309 OMIM: 614262 GeneReviews: Not available
    		not available
    NEK9-related lethal skeletal dysplasia
    MedGen: C5568141 OMIM: 617022 GeneReviews: Not available
    		not available
    Nevus comedonicus syndrome
    MedGen: C0265987 OMIM: 617025 GeneReviews: Not available
    		not available

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    HIV-1 interactions

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    Replication interactions

    Interaction Pubs
    Knockdown of NIMA-related kinase 9 (NEK9) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC16714, MGC138306, DKFZp434D0935

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables 3-phosphoinositide-dependent protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables AMP-activated protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-dependent protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables Rho-dependent protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables eukaryotic translation initiation factor 2alpha kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AS1 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AS121 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AT120 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AXS139 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2BS14 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2BS36 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3S10 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3S28 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3S57 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3T11 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3T3 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3T45 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3T6 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H4S1 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein kinase activator activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein kinase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein kinase binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables ribosomal protein S6 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mitotic cell cycle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of mitotic cell cycle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    colocalizes_with centrosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    colocalizes_with centrosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    serine/threonine-protein kinase Nek9
    Names
    NIMA (never in mitosis gene a)- related kinase 9
    nercc1 kinase
    nimA-related protein kinase 9
    NP_001316166.1
    NP_001316167.1
    NP_149107.4
    XP_005268266.1
    XP_047287875.1
    XP_054232953.1
    XP_054232954.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_051093.2 RefSeqGene

      Range
      5154..52849
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001329237.2 → NP_001316166.1  serine/threonine-protein kinase Nek9 isoform 1

      Status: REVIEWED

      Source sequence(s)
      AL049780
      Consensus CDS
      CCDS91908.1
      UniProtKB/TrEMBL
      A0A7I2V5R1
      Related
      ENSP00000504620.1, ENST00000678037.1
      Conserved Domains (3) summary
      smart00220
      Location:52 → 308
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd08221
      Location:51 → 308
      STKc_Nek9; Catalytic domain of the Protein Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 9
      pfam00415
      Location:444 → 495
      RCC1; Regulator of chromosome condensation (RCC1) repeat

    2. NM_001329238.2 → NP_001316167.1  serine/threonine-protein kinase Nek9 isoform 3

      Status: REVIEWED

      Source sequence(s)
      AL049780
      Consensus CDS
      CCDS91907.1
      UniProtKB/TrEMBL
      A0A7I2V454
      Related
      ENSP00000503827.1, ENST00000678531.1

    3. NM_033116.6 → NP_149107.4  serine/threonine-protein kinase Nek9 isoform 2

      See identical proteins and their annotated locations for NP_149107.4

      Status: REVIEWED

      Source sequence(s)
      AL049780
      Consensus CDS
      CCDS9839.1
      UniProtKB/Swiss-Prot
      Q52LK6, Q8NCN0, Q8TCY4, Q8TD19, Q9UPI4, Q9Y6S4, Q9Y6S5, Q9Y6S6
      Related
      ENSP00000238616.5, ENST00000238616.10
      Conserved Domains (3) summary
      smart00220
      Location:52 → 308
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd08221
      Location:51 → 308
      STKc_Nek9; Catalytic domain of the Protein Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 9
      pfam00415
      Location:500 → 547
      RCC1; Regulator of chromosome condensation (RCC1) repeat

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000014.9 Reference GRCh38.p14 Primary Assembly

      Range
      75079353..75127202 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047431919.1 → XP_047287875.1  serine/threonine-protein kinase Nek9 isoform X2

      UniProtKB/TrEMBL
      A0A7I2V454
      Related
      ENSP00000504104.1, ENST00000678749.1

    2. XM_005268209.4 → XP_005268266.1  serine/threonine-protein kinase Nek9 isoform X1

      Conserved Domains (2) summary
      cl21453
      Location:1 → 190
      PKc_like; Protein Kinases, catalytic domain
      cl27697
      Location:227 → 582
      RCC1; Regulator of chromosome condensation (RCC1) repeat

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060938.1 Alternate T2T-CHM13v2.0

      Range
      69288752..69338522 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054376979.1 → XP_054232954.1  serine/threonine-protein kinase Nek9 isoform X2

    2. XM_054376978.1 → XP_054232953.1  serine/threonine-protein kinase Nek9 isoform X1

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8TD19.2 GenPept UniProtKB/Swiss-Prot:Q8TD19

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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