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    Dh44-R2 Diuretic hormone 44 receptor 2 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 36368, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Dh44-R2provided by FlyBase
    Official Full Name
    Diuretic hormone 44 receptor 2provided by FlyBase
    Primary source
    FLYBASE:FBgn0033744
    Locus tag
    Dmel_CG12370
    See related
    AllianceGenome:FB:FBgn0033744
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-WO0170980.103; anon-WO0170980.104; CG12370; CG13156; DH-R; DH44-R2; Dh442; Dh44R2; DH44R2; DH[[44]]-R2; Dmel\CG12370
    Summary
    Enables diuretic hormone receptor activity. Involved in G protein-coupled receptor signaling pathway; hormone-mediated signaling pathway; and response to salt stress. Located in plasma membrane. Is expressed in adult Malpighian tubule; adult brain; adult enteroendocrine cell; and adult pars intercerebralis. Human ortholog(s) of this gene implicated in asthma; chronic obstructive pulmonary disease; and obesity. Orthologous to human LINC02210-CRHR1 (LINC02210-CRHR1 readthrough); CRHR1 (corticotropin releasing hormone receptor 1); and CRHR2 (corticotropin releasing hormone receptor 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Dh44-R2 in Genome Data Viewer
    Location:
    49A7-49A9; 2-67 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (12474424..12487986)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (8361929..8375491)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene dim gamma-tubulin 5 Neighboring gene uncharacterized protein Neighboring gene Neprilysin-like 10 Neighboring gene uncharacterized protein Neighboring gene fused lobes Neighboring gene stanley-cup Neighboring gene vismay

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. New insights into the evolution of vertebrate CRH (corticotropin-releasing hormone) and invertebrate DH44 (diuretic hormone 44) receptors in metazoans. Cardoso JC, et al. Gen Comp Endocrinol, 2014 Dec 1. PMID 25230393
    2. The prandial process in flies. Mahishi D, et al. Curr Opin Insect Sci, 2019 Dec. PMID 31765996
    3. Nematode and arthropod genomes provide new insights into the evolution of class 2 B1 GPCRs. Cardoso JC, et al. PLoS One, 2014. PMID 24651821, Free PMC Article
    4. The corticotropin-releasing factor-like diuretic hormone 44 (DH44) and kinin neuropeptides modulate desiccation and starvation tolerance in Drosophila melanogaster. Cannell E, et al. Peptides, 2016 Jun. PMID 26896569, Free PMC Article
    5. Long-term neuropeptide modulation of female sexual drive via the TRP channel in Drosophila melanogaster. Kim DH, et al. Proc Natl Acad Sci U S A, 2024 Mar 5. PMID 38412134, Free PMC Article

    See all (73) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The Dh44/DH44 receptor system directs the detection and consumption of nutritive sugars through a positive feedback loop.
      Title: Nutrient Sensor in the Brain Directs the Action of the Brain-Gut Axis in Drosophila.
    2. Fundamental differences in signaling, association with the arrestins, and peptide sensitivity between CG8422 and CG12370 are discussed.
      Title: Functional differences between two CRF-related diuretic hormone receptors in Drosophila.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables G protein-coupled peptide receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables G protein-coupled receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables calcitonin receptor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables diuretic hormone receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables diuretic hormone receptor activity IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables diuretic hormone receptor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables neuropeptide receptor activity ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    enables peptide hormone binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in G protein-coupled receptor signaling pathway ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    involved_in G protein-coupled receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in adenylate cyclase-modulating G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell surface receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in hormone-mediated signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in response to salt stress IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    located_in membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    diuretic hormone 44 receptor 2
    Names
    CG12370-PA
    CG12370-PB
    CRF-like diuretic hormonereceptor 2
    Dh44 receptor 2
    Dh44-R2-PA
    Dh44-R2-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      12474424..12487986
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_136945.4 → NP_610789.3  diuretic hormone 44 receptor 2, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_610789.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      E2QCM9
      Conserved Domains (2) summary
      pfam00002
      Location:159 → 407
      7tm_2; 7 transmembrane receptor (Secretin family)
      pfam02793
      Location:82 → 144
      HRM; Hormone receptor domain

    2. NM_165907.4 → NP_725175.3  diuretic hormone 44 receptor 2, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_725175.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q4V3E9
      Conserved Domains (2) summary
      pfam00002
      Location:159 → 407
      7tm_2; 7 transmembrane receptor (Secretin family)
      pfam02793
      Location:82 → 144
      HRM; Hormone receptor domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    E2QCM9 E2QCM9
    Q4V3E9 Q4V3E9

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