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    RNASEK Ribonuclease kappa [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 3355016, updated on 9-Dec-2024

    Summary

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    Official Symbol
    RNASEKprovided by FlyBase
    Official Full Name
    Ribonuclease kappaprovided by FlyBase
    Primary source
    FLYBASE:FBgn0262116
    Locus tag
    Dmel_CG40127
    See related
    AllianceGenome:FB:FBgn0262116
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-EST:Posey156; BcDNA:GM16138; CG40127; Dmel\CG40127; dRNASEK; GM16138; l(2)NC110; NC110
    Summary
    Predicted to enable RNA endonuclease activity. Involved in cellular response to virus. Orthologous to human RNASEK (ribonuclease K). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See RNASEK in Genome Data Viewer
    Location:
    41A1-41A1; 2-55 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (4186835..4188127, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (74340..75632, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene haspin Neighboring gene uncharacterized protein Neighboring gene Integrator 3 Neighboring gene G protein-coupled receptor kinase 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. RNASEK is required for internalization of diverse acid-dependent viruses. Hackett BA, et al. Proc Natl Acad Sci U S A, 2015 Jun 23. PMID 26056282, Free PMC Article
    2. Genome-wide RNAi screen of Ca(2+) influx identifies genes that regulate Ca(2+) release-activated Ca(2+) channel activity. Zhang SL, et al. Proc Natl Acad Sci U S A, 2006 Jun 13. PMID 16751269, Free PMC Article
    3. Essential loci in centromeric heterochromatin of Drosophila melanogaster. I: the right arm of chromosome 2. Coulthard AB, et al. Genetics, 2010 Jun. PMID 20382826, Free PMC Article
    4. Intrinsic maturation of sleep output neurons regulates sleep ontogeny in Drosophila. Gong NN, et al. Curr Biol, 2022 Sep 26. PMID 35985328, Free PMC Article
    5. FlyAtlas 2 in 2022: enhancements to the Drosophila melanogaster expression atlas. Krause SA, et al. Nucleic Acids Res, 2022 Jan 7. PMID 34718735, Free PMC Article

    See all (32) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    • Annotated by Drosophila Heterochromatin Genome Project, Lawrence Berkeley National Lab, http://www.dhgp.org

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables RNA endonuclease activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA endonuclease activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA endonuclease activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in cellular response to virus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    ribonuclease kappa
    Names
    CG40127-PA
    CG40127-PB
    RNASEK-PA
    RNASEK-PB
    lethal (2) NC110

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      4186835..4188127 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001273770.2 → NP_001260699.1  ribonuclease kappa, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260699.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8MSF5
      UniProtKB/TrEMBL
      A0A0B4KEQ9

    2. NM_001042968.2 → NP_001036433.1  ribonuclease kappa, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001036433.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8MSF5
      UniProtKB/TrEMBL
      A0A0B4KEQ9
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4KEQ9 A0A0B4KEQ9
    Q8MSF5.1 Q8MSF5

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