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    Abcb9 ATP binding cassette subfamily B member 9 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 63886, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Abcb9provided by RGD
    Official Full Name
    ATP binding cassette subfamily B member 9provided by RGD
    Primary source
    RGD:620254
    See related
    EnsemblRapid:ENSRNOG00000001082 AllianceGenome:RGD:620254
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Tapl
    Summary
    Predicted to enable ABC-type transporter activity; ATP binding activity; and protein homodimerization activity. Predicted to be involved in peptide metabolic process; peptide transport; and transmembrane transport. Predicted to be located in endoplasmic reticulum membrane and lysosomal membrane. Predicted to be part of ATP-binding activity cassette (ABC) transporter complex. Predicted to be active in membrane. Orthologous to human ABCB9 (ATP binding cassette subfamily B member 9). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 60.2), Muscle (RPKM 37.6) and 8 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Abcb9 in Genome Data Viewer
    Location:
    12q15
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 12 NC_086030.1 (38146659..38192862)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 12 NC_051347.1 (32499213..32531932)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 12 NC_005111.4 (37923974..37956678)

    Chromosome 12 - NC_086030.1Genomic Context describing neighboring genes Neighboring gene ARF like GTPase 6 interacting protein 4 Neighboring gene U6 spliceosomal RNA Neighboring gene 2-oxoglutarate and iron-dependent oxygenase domain containing 2 Neighboring gene uncharacterized LOC102552690 Neighboring gene keratin-associated protein 4-6-like Neighboring gene VPS37B subunit of ESCRT-I Neighboring gene huntingtin interacting protein 1 related

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. The carboxyl terminal sequence of rat transporter associated with antigen processing (TAP)-like (ABCB9) is heterogeneous due to splicing of its mRNA. Yamaguchi Y, et al. Biol Pharm Bull, 2004 Jan. PMID 14709908
    2. An ABC transporter homologous to TAP proteins. Yamaguchi Y, et al. FEBS Lett, 1999 Aug 27. PMID 10471785
    3. Functional dissection of transmembrane domains of human TAP-like (ABCB9). Kamakura A, et al. Biochem Biophys Res Commun, 2008 Dec 19. PMID 18952056
    4. Peptide specificity and lipid activation of the lysosomal transport complex ABCB9 (TAPL). Zhao C, et al. J Biol Chem, 2008 Jun 20. PMID 18434309
    5. Identification of a lysosomal peptide transport system induced during dendritic cell development. Demirel O, et al. J Biol Chem, 2007 Dec 28. PMID 17977821

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ABC-type oligopeptide transporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ABC-type oligopeptide transporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables ABC-type peptide transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ABC-type peptide transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ABC-type peptide transporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATPase-coupled transmembrane transporter activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    NOT involved_in antigen processing and presentation of peptide antigen via MHC class I ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in oligopeptide transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in peptide metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in peptide metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in peptide transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in peptide transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in peptide transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of ATP-binding cassette (ABC) transporter complex TAS
    Traceable Author Statement
    more info
    		 PubMed 
    NOT located_in early endosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    NOT located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in lysosomal membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in lysosomal membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in lysosomal membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in lysosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in lysosome ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    ABC-type oligopeptide transporter ABCB9
    Names
    ABC transporter 9 protein
    ATP-binding cassette sub-family B member 9
    ATP-binding cassette transporter 9
    ATP-binding cassette, sub-family B (MDR/TAP), member 9
    ATP-binding cassette, subfamily B (MDR/TAP), member 9
    TAP-like ABC transporter
    TAP-like protein
    NP_071574.1
    XP_038945646.1
    XP_063127680.1
    XP_063127681.1
    XP_063127682.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_022238.3 → NP_071574.1  ABC-type oligopeptide transporter ABCB9

      See identical proteins and their annotated locations for NP_071574.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000012
      UniProtKB/Swiss-Prot
      Q764Q5, Q764Q6, Q9QYJ4
      UniProtKB/TrEMBL
      A0A0A0MY39, A6J117
      Related
      ENSRNOP00000096168.1, ENSRNOT00000098844.2
      Conserved Domains (3) summary
      cd03248
      Location:489 → 714
      ABCC_TAP; ATP-binding cassette domain of the Transporter Associated with Antigen Processing, subfamily C
      TIGR00958
      Location:44 → 734
      3a01208; Conjugate Transporter-2 (CT2) Family protein
      pfam00664
      Location:189 → 451
      ABC_membrane; ABC transporter transmembrane region

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086030.1 Reference GRCr8

      Range
      38146659..38192862
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063271610.1 → XP_063127680.1  ABC-type oligopeptide transporter ABCB9 isoform X1

      UniProtKB/Swiss-Prot
      Q764Q5, Q764Q6, Q9QYJ4
      UniProtKB/TrEMBL
      A0A0A0MY39, A6J117

    2. XM_063271612.1 → XP_063127682.1  ABC-type oligopeptide transporter ABCB9 isoform X4

      UniProtKB/TrEMBL
      A0A0A0MY39

    3. XM_063271611.1 → XP_063127681.1  ABC-type oligopeptide transporter ABCB9 isoform X3

      UniProtKB/TrEMBL
      A0A0A0MY39
      Related
      ENSRNOP00000083417.1, ENSRNOT00000114288.2

    4. XM_039089718.2 → XP_038945646.1  ABC-type oligopeptide transporter ABCB9 isoform X2

      Conserved Domains (1) summary
      TIGR00958
      Location:35 → 572
      3a01208; Conjugate Transporter-2 (CT2) Family protein
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9QYJ4.1 GenPept UniProtKB/Swiss-Prot:Q9QYJ4

    Gene LinkOut

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