dapk-1 Death-associated protein kinase dapk-1;non-specific serine/threonine protein kinase [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: dapk-1
Official Full Name: Death-associated protein kinase dapk-1;non-specific serine/threonine protein kinase
Primary source: WormBase:WBGene00003400
Locus tag: CELE_K12C11.4
See related: AllianceGenome:WB:WBGene00003400
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable protein serine/threonine kinase activity. Predicted to be involved in intracellular signal transduction and positive regulation of apoptotic process. Predicted to be located in cytoskeleton and cytosol. Predicted to be active in nucleus. Is expressed in body wall musculature and hypodermis. Human ortholog(s) of this gene implicated in urinary bladder cancer and uterine fibroid. Orthologous to several human genes including DAPK1 (death associated protein kinase 1). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See dapk-1 in Genome Data Viewer

Location:: chromosome: I

Exon count:: 14

Sequence:: Chromosome: I; NC_003279.8 (1305562..1328648)

Chromosome I - NC_003279.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

DAPK-1 and PTRN-1 physically interact in co-immunoprecipitation experiments, and DAPK-1 itself undergoes microtubule-dependent transport.
Title: DAPK interacts with Patronin and the microtubule cytoskeleton in epidermal development and wound repair.
loss of sydn-1 blocks ectopic expression of neuronal ankyrin and suppresses epidermal morphology defects of dapk-1; effects of sydn-1 are mediated by ssup-72 autonomously in the epidermis
Title: Tissue-specific regulation of alternative polyadenylation represses expression of a neuronal ankyrin isoform in C. elegans epidermal development.
studies highlight the prominence of DAPK and Pin1/PINN-1 as conserved mediators of cell death processes in diverse scenarios of neurodegeneration
Title: Death Associated Protein Kinase (DAPK) -mediated neurodegenerative mechanisms in nematode excitotoxicity.
The death-associated protein kinase DAPK-1 acts as a negative regulator of wound closure.
Title: A Gαq-Ca²⁺ signaling pathway promotes actin-mediated epidermal wound closure in C. elegans.
Death-associated protein kinase (DAPK) and signal transduction: fine-tuning of autophagy in homeostasis. Review.
Title: Death-associated protein kinase (DAPK) and signal transduction: fine-tuning of autophagy in Caenorhabditis elegans homeostasis.
Overexpression of DAPK-1 represses innate immune responses to needle wounding
Title: Negative regulation of Caenorhabditis elegans epidermal damage responses by death-associated protein kinase.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

K12C11.4 (e-PCR)
- UniSTS:313249

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables GTP binding	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables protein kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cell communication	IEA Inferred from Electronic Annotation more info
involved_in innate immune response	IEA Inferred from Electronic Annotation more info
involved_in intracellular signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of apoptotic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in regulation of response to stimulus	IEA Inferred from Electronic Annotation more info
involved_in signal transduction	IEA Inferred from Electronic Annotation more info
involved_in signaling	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: Death-associated protein kinase dapk-1;non-specific serine/threonine protein kinase

NP_001293415.1

Confirmed by transcript evidence

NP_001293416.1

Confirmed by transcript evidence

NP_001293417.1

Confirmed by transcript evidence

NP_490840.2

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003279.8 Reference assembly

Range

1305562..1328648

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_058439.5 → NP_490840.2 Death-associated protein kinase dapk-1 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_490840.2

Status: REVIEWED

UniProtKB/Swiss-Prot

O44997, Q3ZLV1

Conserved Domains (7) summary

smart00220
Location:28 → 289

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd00204
Location:521 → 644

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

cd08782
Location:1304 → 1386

Death_DAPK1; Death domain found in death-associated protein kinase 1

pfam12796
Location:562 → 653

Ank_2; Ankyrin repeats (3 copies)

sd00045
Location:524 → 555

ANK; ANK repeat [structural motif]

cl21453
Location:25 → 289

PKc_like; Protein Kinases, catalytic domain

cl21455
Location:777 → 895

P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
NM_001306486.3 → NP_001293415.1 non-specific serine/threonine protein kinase [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001293415.1

Status: REVIEWED

UniProtKB/TrEMBL

W6RTC2

Conserved Domains (8) summary

smart00220
Location:7 → 128

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd00204
Location:360 → 483

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

cd08782
Location:1143 → 1225

Death_DAPK1; Death domain found in death-associated protein kinase 1

pfam12796
Location:401 → 492

Ank_2; Ankyrin repeats (3 copies)

pfam16095
Location:808 → 952

COR; C-terminal of Roc, COR, domain

sd00045
Location:363 → 394

ANK; ANK repeat [structural motif]

cl21453
Location:9 → 128

PKc_like; Protein Kinases, catalytic domain

cl21455
Location:616 → 734

P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
NM_001306487.3 → NP_001293416.1 non-specific serine/threonine protein kinase [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001293416.1

Status: REVIEWED

UniProtKB/TrEMBL

W6SBC4

Conserved Domains (7) summary

cd00204
Location:125 → 248

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

cd08782
Location:908 → 990

Death_DAPK1; Death domain found in death-associated protein kinase 1

pfam12796
Location:166 → 257

Ank_2; Ankyrin repeats (3 copies)

pfam13637
Location:30 → 79

Ank_4; Ankyrin repeats (many copies)

pfam16095
Location:573 → 717

COR; C-terminal of Roc, COR, domain

sd00045
Location:128 → 159

ANK; ANK repeat [structural motif]

cl21455
Location:381 → 499

P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
NM_001306488.3 → NP_001293417.1 non-specific serine/threonine protein kinase [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001293417.1

Status: REVIEWED

UniProtKB/TrEMBL

W6RQW7

Conserved Domains (6) summary

cd00204
Location:172 → 290

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

cd08782
Location:806 → 888

Death_DAPK1; Death domain found in death-associated protein kinase 1

pfam12796
Location:208 → 299

Ank_2; Ankyrin repeats (3 copies)

pfam13637
Location:173 → 224

Ank_4; Ankyrin repeats (many copies)

sd00045
Location:170 → 201

ANK; ANK repeat [structural motif]

cl21455
Location:423 → 541

P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases