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    ncx-4 Sodium/calcium exchanger membrane region domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 172834, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ncx-4
    Official Full Name
    Sodium/calcium exchanger membrane region domain-containing protein
    Primary source
    WormBase:WBGene00003569
    Locus tag
    CELE_F35C12.2
    See related
    AllianceGenome:WB:WBGene00003569
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable calcium channel activity and calcium, potassium:sodium antiporter activity. Predicted to be involved in calcium ion transmembrane transport and intracellular calcium ion homeostasis. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in amphid neurons; labial sensillum; somatic nervous system; and tail neurons. Human ortholog(s) of this gene implicated in congenital stationary night blindness 1D. Orthologous to human SLC24A1 (solute carrier family 24 member 1) and SLC24A2 (solute carrier family 24 member 2). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See ncx-4 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    10
    Sequence:
    Chromosome: I; NC_003279.8 (9808904..9813075)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Activin_recp domain-containing protein Neighboring gene Phospholipase A1 Neighboring gene ncRNA Neighboring gene Non-histone chromosomal protein HMG-14

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Minimal domain requirement for cation transport by the potassium-dependent Na/Ca-K exchanger. Comparison with an NCKX paralog from Caenorhabditis elegans. Szerencsei RT, et al. J Biol Chem, 2000 Jan 7. PMID 10617665
    2. Pan-phylum genome-wide identification of sodium calcium exchangers reveal heterogeneous expansions and possible roles in nematode parasitism. Bode K, et al. Gene, 2022 Feb 5. PMID 34756961
    3. Determining Toxic Potencies of Water-Soluble Contaminants in Wastewater Influents and Effluent Using Gene Expression Profiling in C. elegans as a Bioanalytical Tool. Karengera A, et al. Arch Environ Contam Toxicol, 2022 Oct. PMID 36190544, Free PMC Article
    4. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
    5. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables antiporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables calcium channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables calcium, potassium:sodium antiporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in calcium ion transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in calcium ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in intracellular calcium ion homeostasis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in potassium ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in sodium ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Sodium/calcium exchanger membrane region domain-containing protein
    NP_001040663.1
    • Confirmed by transcript evidence
    NP_001040664.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      9808904..9813075
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001047198.5 → NP_001040663.1  Sodium/calcium exchanger membrane region domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001040663.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      O62306, P90858
      Conserved Domains (1) summary
      TIGR00927
      Location:48 → 594
      2A1904; K+-dependent Na+/Ca+ exchanger

    2. NM_001047199.4 → NP_001040664.1  Sodium/calcium exchanger membrane region domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001040664.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q1ZXT5
      Conserved Domains (1) summary
      TIGR00927
      Location:1 → 152
      2A1904; K+-dependent Na+/Ca+ exchanger
    Nucleotide Protein
    Heading Accession and Version

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