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    NXF3 nuclear RNA export factor 3 [ Homo sapiens (human) ]

    Gene ID: 56000, updated on 10-Dec-2024

    Summary

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    Official Symbol
    NXF3provided by HGNC
    Official Full Name
    nuclear RNA export factor 3provided by HGNC
    Primary source
    HGNC:HGNC:8073
    See related
    Ensembl:ENSG00000147206 MIM:300316; AllianceGenome:HGNC:8073
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    This gene is one member of a family of nuclear RNA export factor genes. Common domain features of this family are a noncanonical RNP-type RNA-binding domain (RBD), 4 leucine-rich repeats (LRRs), a nuclear transport factor 2 (NTF2)-like domain that allows heterodimerization with NTF2-related export protein-1 (NXT1), and a ubiquitin-associated domain that mediates interactions with nucleoporins. The LRRs and NTF2-like domains are required for export activity. Alternative splicing seems to be a common mechanism in this gene family. The encoded protein of this gene has shortened LRR and ubiquitin-associated domains and its RDB is unable to bind RNA. It is located in the nucleoplasm but is not associated with either the nuclear envelope or the nucleolus. [provided by RefSeq, Jul 2008]
    Expression
    Biased expression in testis (RPKM 42.7), gall bladder (RPKM 7.2) and 1 other tissue See more
    Orthologs
    mouse all
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    Genomic context

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    See NXF3 in Genome Data Viewer
    Location:
    Xq22.1
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) X NC_000023.11 (103075810..103093143, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) X NC_060947.1 (101520737..101538070, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (102330738..102348071, complement)

    Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene NUDT19 pseudogene 2 Neighboring gene Sharpr-MPRA regulatory region 49 Neighboring gene brain expressed X-linked 1 Neighboring gene zinc finger protein 770 pseudogene Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chrX:102358711-102359380 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chrX:102438681-102439434 Neighboring gene CRISPRi-validated cis-regulatory element chrX.1663 Neighboring gene ribosomal protein SA pseudogene 59 Neighboring gene brain expressed X-linked 4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. AF119895 regulates NXF3 expression to promote migration and invasion of hepatocellular carcinoma through an interaction with miR-6508-3p. Zeng T, et al. Exp Cell Res, 2018 Feb 1. PMID 29274323
    2. Two closely related human nuclear export factors utilize entirely distinct export pathways. Yang J, et al. Mol Cell, 2001 Aug. PMID 11545741
    3. Formation of a Tap/NXF1 homotypic complex is mediated through the amino-terminal domain of Tap and enhances interaction with nucleoporins. Matzat LH, et al. Mol Biol Cell, 2008 Jan. PMID 17978099, Free PMC Article
    4. NXF5, a novel member of the nuclear RNA export factor family, is lost in a male patient with a syndromic form of mental retardation. Jun L, et al. Curr Biol, 2001 Sep 18. PMID 11566096
    5. TAP (NXF1) belongs to a multigene family of putative RNA export factors with a conserved modular architecture. Herold A, et al. Mol Cell Biol, 2000 Dec. PMID 11073998, Free PMC Article

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. observations collectively demonstrate that AF119895 modulates the repression of NXF3 by binding to miR-6508-3p
      Title: AF119895 regulates NXF3 expression to promote migration and invasion of hepatocellular carcinoma through an interaction with miR-6508-3p.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in mRNA export from nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in mRNA export from nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in poly(A)+ mRNA export from nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of nuclear RNA export factor complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of nuclear RNA export factor complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    part_of nuclear RNA export factor complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    nuclear RNA export factor 3
    Names
    TAP-like protein 3
    TAPL-3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_012572.1 RefSeqGene

      Range
      4952..22285
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_022052.2 → NP_071335.1  nuclear RNA export factor 3

      See identical proteins and their annotated locations for NP_071335.1

      Status: REVIEWED

      Source sequence(s)
      AJ277527, Z75746
      Consensus CDS
      CCDS14503.1
      UniProtKB/Swiss-Prot
      B4DYS7, Q5H9I1, Q9H1A9, Q9H4D5
      Related
      ENSP00000378504.3, ENST00000395065.8
      Conserved Domains (3) summary
      cd00780
      Location:341 → 496
      NTF2; Nuclear transport factor 2 (NTF2) domain plays an important role in the trafficking of macromolecules, ions and small molecules between the cytoplasm and nucleus. This bi-directional transport of macromolecules across the nuclear envelope requires many ...
      sd00035
      Location:218 → 260
      LRR_NTF; leucine-rich repeat [structural motif]
      pfam09162
      Location:110 → 192
      Tap-RNA_bind; Tap, RNA-binding

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000023.11 Reference GRCh38.p14 Primary Assembly

      Range
      103075810..103093143 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060947.1 Alternate T2T-CHM13v2.0

      Range
      101520737..101538070 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9H4D5.1 GenPept UniProtKB/Swiss-Prot:Q9H4D5

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