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    kcnn1b potassium intermediate/small conductance calcium-activated channel, subfamily N, member 1b [ Danio rerio (zebrafish) ]

    Gene ID: 570401, updated on 9-Dec-2024

    Summary

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    Official Symbol
    kcnn1bprovided by ZNC
    Official Full Name
    potassium intermediate/small conductance calcium-activated channel, subfamily N, member 1bprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-060503-397
    See related
    Ensembl:ENSDARG00000023546 AllianceGenome:ZFIN:ZDB-GENE-060503-397
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    sk1; kcnn1; si:ch211-200a16.1
    Summary
    Predicted to enable calmodulin binding activity and small conductance calcium-activated potassium channel activity. Predicted to be involved in potassium ion transmembrane transport. Predicted to act upstream of or within monoatomic ion transmembrane transport and potassium ion transport. Predicted to be located in membrane. Predicted to be active in neuron projection; neuronal cell body; and plasma membrane. Is expressed in several structures, including heart; nervous system; pectoral fin bud; segmental plate; and tail bud. Orthologous to human KCNN1 (potassium calcium-activated channel subfamily N member 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See kcnn1b in Genome Data Viewer
    Location:
    chromosome: 8
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 8 NC_007119.7 (13239572..13336312, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 8 NC_007119.6 (13206349..13298576, complement)

    Chromosome 8 - NC_007119.7Genomic Context describing neighboring genes Neighboring gene zgc:194990 Neighboring gene si:ch73-61d6.3 Neighboring gene uncharacterized LOC110440006 Neighboring gene uncharacterized LOC101886813 Neighboring gene coiled-coil domain containing 124 Neighboring gene solute carrier family 5 member 5

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Calcium-activated potassium channel SK1 is widely expressed in the peripheral nervous system and sensory organs of adult zebrafish. Cabo R, et al. Neurosci Lett, 2013 Oct 25. PMID 24060674
    2. Unraveling the Molecular Players at the Cholinergic Efferent Synapse of the Zebrafish Lateral Line. Carpaneto Freixas AE, et al. J Neurosci, 2021 Jan 6. PMID 33203744, Free PMC Article
    3. Parental exposure to environmental concentrations of tris(1,3-dichloro-2-propyl)phosphate induces abnormal DNA methylation and behavioral changes in F1 zebrafish larvae. Ding X, et al. Environ Pollut, 2020 Dec. PMID 32841905
    4. Atrium-specific ion channels in the zebrafish-A role of I(KACh) in atrial repolarization. Skarsfeldt MA, et al. Acta Physiol (Oxf), 2018 Jul. PMID 29412518
    5. Phylogenetic and developmental analyses indicate complex functions of calcium-activated potassium channels in zebrafish embryonic development. Silic MR, et al. Dev Dyn, 2021 Oct. PMID 33728688, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. the expression and the distribution of SK1 in the peripheral nervous system and sensory organs of adult zebrafish
      Title: Calcium-activated potassium channel SK1 is widely expressed in the peripheral nervous system and sensory organs of adult zebrafish.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables calcium-activated potassium channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables calmodulin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables small conductance calcium-activated potassium channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within monoatomic ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within monoatomic ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within potassium ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    small conductance calcium-activated potassium channel protein 1b
    Names
    potassium intermediate/small conductance calcium-activated channel, subfamily N, member 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001045199.3 → NP_001038664.1  small conductance calcium-activated potassium channel protein 1b isoform 2

      See identical proteins and their annotated locations for NP_001038664.1

      Status: PROVISIONAL

      Source sequence(s)
      BC153898
      UniProtKB/TrEMBL
      A8KAZ6, Q1LY45
      Related
      ENSDARP00000007813.7, ENSDART00000014528.9
      Conserved Domains (3) summary
      pfam02888
      Location:64 → 136
      CaMBD; Calmodulin binding domain
      pfam07885
      Location:1 → 50
      Ion_trans_2; Ion channel
      cl09111
      Location:98 → 176
      Prefoldin; Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta subunits, the two subunits ...

    2. NM_001328106.1 → NP_001315035.1  small conductance calcium-activated potassium channel protein 1b isoform 1

      Status: PROVISIONAL

      Source sequence(s)
      BX119975
      UniProtKB/TrEMBL
      A0A0R4IC13, A0A8M1P9X7, A0A8M9Q9S4
      Related
      ENSDARP00000130450.2, ENSDART00000168635.2
      Conserved Domains (4) summary
      smart01053
      Location:373 → 451
      CaMBD; Calmodulin binding domain
      pfam03530
      Location:85 → 192
      SK_channel; Calcium-activated SK potassium channel
      pfam07885
      Location:280 → 359
      Ion_trans_2; Ion channel
      cl09111
      Location:414 → 500
      Prefoldin; Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta subunits, the two subunits ...

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007119.7 Reference GRCz11 Primary Assembly

      Range
      13239572..13336312 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005166885.5 → XP_005166942.1  small conductance calcium-activated potassium channel protein 1b isoform X1

      UniProtKB/TrEMBL
      A0A8M2BE84, A0A8M9Q3J1
      Conserved Domains (4) summary
      pfam02888
      Location:640 → 712
      CaMBD; Calmodulin binding domain
      pfam03530
      Location:352 → 459
      SK_channel; Calcium-activated SK potassium channel
      pfam07885
      Location:547 → 626
      Ion_trans_2; Ion channel
      cl09111
      Location:674 → 752
      Prefoldin; Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta subunits, the two subunits ...

    2. XM_068223006.1 → XP_068079107.1  small conductance calcium-activated potassium channel protein 1b isoform X2

      UniProtKB/TrEMBL
      A0A8M9Q9S4
    Nucleotide Protein
    Heading Accession and Version

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