Fcgr4 Fc receptor, IgG, low affinity IV [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Fcgr4provided by MGI
Official Full Name: Fc receptor, IgG, low affinity IVprovided by MGI
Primary source: MGI:MGI:2179523
See related: Ensembl:ENSMUSG00000059089 AllianceGenome:MGI:2179523
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Fcrl3; CD16-2; FcgRIV; Fcgr3a; FcgammaRIV; 4833442P21Rik
Summary: Enables IgE receptor activity and IgG receptor activity. Involved in several processes, including Fc receptor-mediated immune complex endocytosis; neutrophil activation; and positive regulation of bone resorption. Located in cell surface and plasma membrane. Is expressed in liver. Human ortholog(s) of this gene implicated in several diseases, including allergic disease (multiple); autoimmune disease (multiple); glomerulonephritis (multiple); graft-versus-host disease; and hematologic cancer (multiple). Orthologous to several human genes including FCGR3A (Fc gamma receptor IIIa). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Broad expression in liver E18 (RPKM 7.9), spleen adult (RPKM 4.1) and 17 other tissues See more
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Genomic context

Location:: 1 H3; 1 78.53 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	1	NC_000067.7 (170846495..170857330)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	1	NC_000067.6 (171018926..171029761)

Chromosome 1 - NC_000067.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Fc gammaRIV (FcgammaRIV) mediates bone erosion in antigen-induced arthritis (AIA) by inducing the influx of S100A8/A9-producing neutrophils into the arthritic joint.
Title: Fcγ receptor-mediated influx of S100A8/A9-producing neutrophils as inducer of bone erosion during antigen-induced arthritis.
The IgG2 immune complexes activates osteoclastogenesis by binding to FcgammaRIThe IgG2 immune complexes activates osteoclastogenesis by binding to FcgammaRIV.
Title: Immune complexes regulate bone metabolism through FcRγ signalling.
antibody orchestrated Fcgamma receptor-mediated switch in inflammation is one mechanism underlying inhibition of axon regeneration
Title: Fcγ receptor-mediated inflammation inhibits axon regeneration.
The human natural killer cytotoxic cell line NK-92, once armed with a murine CD16 receptor, represents a convenient cellular tool for the screening of mouse mAbs according to their ADCC potential.
Title: The human natural killer cytotoxic cell line NK-92, once armed with a murine CD16 receptor, represents a convenient cellular tool for the screening of mouse mAbs according to their ADCC potential.
FcgammaRIV expression and function on osteoclasts during the steady state and during acute joint inflammation in a model of inflammatory arthritis
Title: Inflammatory monocytes and Fcγ receptor IV on osteoclasts are critical for bone destruction during inflammatory arthritis in mice.
The mechanism(s) of phagocytosis in the second phase of blood incompatibility reaction required neither C3 nor FcgammaRs.
Title: Biphasic clearance of incompatible red blood cells through a novel mechanism requiring neither complement nor Fcγ receptors in a murine model.
Our findings both genetically and functionally identify a novel disease-related molecule, FcgammaRIV, in an autoantibody-mediated disorder, which may be of importance for the development of novel targeted therapies.
Title: Genetic identification and functional validation of FcγRIV as key molecule in autoantibody-induced tissue injury.
Two activating IgG receptors, FcgammaRIIIA and FcgammaRIV, expressed in mast cells are responsible for serum-induced passive arthritis in wild type mice.
Title: Cutting Edge: The murine high-affinity IgG receptor FcγRIV is sufficient for autoantibody-induced arthritis.
a variety of IgG2a- and IgG2b-dependent effector functions are impaired in the absence of Fcgr4 in models of autoimmunity and antibody-dependent cellular cytotoxicity.
Title: FcγRIV deletion reveals its central role for IgG2a and IgG2b activity in vivo.
Results demonstrate a combined requirement for FcgammaRIII and FcgammaRIV in autoimmune injury, and identify the linker for activation of T cells adaptor as an integral component of linked FcgammaR and C5a activation to generate inflammation.
Title: Both FcgammaRIV and FcgammaRIII are essential receptors mediating type II and type III autoimmune responses via FcRgamma-LAT-dependent generation of C5a.

Submit: New GeneRIF Correction See all GeneRIFs (18)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (7)
Gene trapped (1)
Targeted (5) 1 citation

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables GPI anchor binding	ISO Inferred from Sequence Orthology more info
enables IgE binding	IEA Inferred from Electronic Annotation more info
enables IgE receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables IgG binding	IEA Inferred from Electronic Annotation more info
enables IgG receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables IgG receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables immune receptor activity	ISO Inferred from Sequence Orthology more info
enables immune receptor activity	ISS Inferred from Sequence or Structural Similarity more info
enables low-affinity IgG receptor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in Fc receptor-mediated immune complex endocytosis	IDA Inferred from Direct Assay more info	PubMed
involved_in Fc-epsilon receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in Fc-gamma receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in antibody-dependent cellular cytotoxicity	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell surface receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in cellular response to lipopolysaccharide	ISO Inferred from Sequence Orthology more info
involved_in dendritic cell antigen processing and presentation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in natural killer cell degranulation	ISS Inferred from Sequence or Structural Similarity more info
involved_in neutrophil activation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in perforin production	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of bone resorption	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of Fc-gamma receptor III complex	ISO Inferred from Sequence Orthology more info
located_in cell surface	IDA Inferred from Direct Assay more info	PubMed
located_in cell surface	ISO Inferred from Sequence Orthology more info
is_active_in external side of plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in external side of plasma membrane	ISO Inferred from Sequence Orthology more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: low affinity immunoglobulin gamma Fc region receptor III-A

Names: Fc fragment of IgG, low affinity IIIa, receptor for (CD16); Fc fragment of IgG, low affinity III, receptor for (CD16); Fc gammaRIV; Fc receptor-like 3; IgG Fc receptor III-A; low affinity immunoglobulin gamma Fc region receptor IV

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_144559.2 → NP_653142.2 low affinity immunoglobulin gamma Fc region receptor III-A precursor

See identical proteins and their annotated locations for NP_653142.2

Status: VALIDATED

Source sequence(s)

AC115959, AK076532, AK087863

Consensus CDS

CCDS15476.1

UniProtKB/Swiss-Prot

A0A0B4J1G0, Q3TC44, Q8R2R4, Q8R477

Related

ENSMUSP00000077873.5, ENSMUST00000078825.5

Conserved Domains (2) summary

cd05752
Location:25 → 103

Ig1_FcgammaR_like; Frst immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs) and similar proteins

cd05753
Location:107 → 188

Ig2_FcgammaR_like; Second immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs) and similar proteins

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000067.7 Reference GRCm39 C57BL/6J

Range

170846495..170857330

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_180961.1: Suppressed sequence

Description

NM_180961.1: This RefSeq record was removed by NCBI staff. Contact [email protected] for further information.