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    METTL25 methyltransferase like 25 [ Homo sapiens (human) ]

    Gene ID: 84190, updated on 10-Dec-2024

    Summary

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    Official Symbol
    METTL25provided by HGNC
    Official Full Name
    methyltransferase like 25provided by HGNC
    Primary source
    HGNC:HGNC:26228
    See related
    Ensembl:ENSG00000127720 AllianceGenome:HGNC:26228
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    C12orf26
    Summary
    Predicted to enable methyltransferase activity. Predicted to be involved in methylation. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Low expression observed in reference dataset See more
    Orthologs
    mouse all
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    Genomic context

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    See METTL25 in Genome Data Viewer
    Location:
    12q21.31
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (82358529..82479239)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (82337989..82458720)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (82752308..82873018)

    Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 2426 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr12:82495963-82497162 Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:82514940-82515440 Neighboring gene uncharacterized LOC105369873 Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:82540979-82541568 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:82707907-82708408 Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:82751975-82752535 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:82752536-82753096 Neighboring gene Sharpr-MPRA regulatory region 15106 Neighboring gene coiled-coil domain containing 59 Neighboring gene hepatitis A virus cellular receptor 1 pseudogene Neighboring gene uncharacterized LOC107987180 Neighboring gene ReSE screen-validated silencer GRCh37_chr12:82926586-82926790 Neighboring gene KIAA1586 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Creation of genome-wide protein expression libraries using random activation of gene expression. Harrington JJ, et al. Nat Biotechnol, 2001 May. PMID 11329013
    2. An organelle-specific protein landscape identifies novel diseases and molecular mechanisms. Boldt K, et al. Nat Commun, 2016 May 13. PMID 27173435, Free PMC Article
    3. In-Depth In Vivo Crosslinking in Minutes by a Compact, Membrane-Permeable, and Alkynyl-Enrichable Crosslinker. Gao H, et al. Anal Chem, 2022 May 31. PMID 35575683
    4. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. Oláh J, et al. J Biol Chem, 2011 Sep 30. PMID 21832049, Free PMC Article
    5. Protein interaction landscapes revealed by advanced in vivo cross-linking-mass spectrometry. Wheat A, et al. Proc Natl Acad Sci U S A, 2021 Aug 10. PMID 34349018, Free PMC Article

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
      Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ22789

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in methylation IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    probable methyltransferase-like protein 25
    Names
    methyltransferase-like protein 25

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_053173.2 RefSeqGene

      Range
      5124..125834
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001319675.2 → NP_001306604.1  probable methyltransferase-like protein 25 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate splice site in the 5' region and initiates translation at downstream start codon compared to variant 1. The encoded isoform (2) has a shorter N-terminus than isoform 1.
      Source sequence(s)
      AC083811, AC089998
      UniProtKB/Swiss-Prot
      Q8N6Q8
      Conserved Domains (1) summary
      cl17173
      Location:67 → 333
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

    2. NM_001347934.2 → NP_001334863.1  probable methyltransferase-like protein 25 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC083811, AC089998
      UniProtKB/Swiss-Prot
      Q8N6Q8

    3. NM_032230.3 → NP_115606.2  probable methyltransferase-like protein 25 isoform 1

      See identical proteins and their annotated locations for NP_115606.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AC083811, AC089998
      Consensus CDS
      CCDS9024.1
      UniProtKB/Swiss-Prot
      Q8N6Q8, Q9H5Y3
      Related
      ENSP00000248306.3, ENST00000248306.8
      Conserved Domains (1) summary
      cl17173
      Location:154 → 420
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

    RNA

    1. NR_144940.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC083811, AC089998

    2. NR_144941.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC083811, AC089998

    3. NR_144942.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC083811, AC089998

    4. NR_144943.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC083811, AC089998

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

      Range
      82358529..82479239
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011538827.4 → XP_011537129.1  probable methyltransferase-like protein 25 isoform X2

      Conserved Domains (1) summary
      cl17173
      Location:99 → 365
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

    2. XM_011538828.4 → XP_011537130.1  probable methyltransferase-like protein 25 isoform X3

      Conserved Domains (1) summary
      cl17173
      Location:154 → 420
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

    3. XM_047429659.1 → XP_047285615.1  probable methyltransferase-like protein 25 isoform X5

    4. XM_011538829.4 → XP_011537131.1  probable methyltransferase-like protein 25 isoform X4

      Related
      ENST00000547357.5
      Conserved Domains (1) summary
      cl17173
      Location:154 → 420
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

    5. XM_047429660.1 → XP_047285616.1  probable methyltransferase-like protein 25 isoform X7

    6. XM_047429661.1 → XP_047285617.1  probable methyltransferase-like protein 25 isoform X8

    7. XM_005269186.6 → XP_005269243.2  probable methyltransferase-like protein 25 isoform X6

      Conserved Domains (1) summary
      cl17173
      Location:154 → 420
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

    8. XM_047429658.1 → XP_047285614.1  probable methyltransferase-like protein 25 isoform X1

    RNA

    1. XR_007063135.1 RNA Sequence

    2. XR_007063138.1 RNA Sequence

    3. XR_944768.4 RNA Sequence

    4. XR_007063137.1 RNA Sequence

    5. XR_007063136.1 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060936.1 Alternate T2T-CHM13v2.0

      Range
      82337989..82458720
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054373450.1 → XP_054229425.1  probable methyltransferase-like protein 25 isoform X2

    2. XM_054373451.1 → XP_054229426.1  probable methyltransferase-like protein 25 isoform X3

    3. XM_054373453.1 → XP_054229428.1  probable methyltransferase-like protein 25 isoform X5

    4. XM_054373452.1 → XP_054229427.1  probable methyltransferase-like protein 25 isoform X4

    5. XM_054373455.1 → XP_054229430.1  probable methyltransferase-like protein 25 isoform X7

    6. XM_054373456.1 → XP_054229431.1  probable methyltransferase-like protein 25 isoform X8

    7. XM_054373454.1 → XP_054229429.1  probable methyltransferase-like protein 25 isoform X6

    8. XM_054373449.1 → XP_054229424.1  probable methyltransferase-like protein 25 isoform X1

    RNA

    1. XR_008488698.1 RNA Sequence

    2. XR_008488701.1 RNA Sequence

    3. XR_008488697.1 RNA Sequence

    4. XR_008488700.1 RNA Sequence

    5. XR_008488699.1 RNA Sequence

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8N6Q8.2 GenPept UniProtKB/Swiss-Prot:Q8N6Q8

    Gene LinkOut

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