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    TCF7L1 transcription factor 7 like 1 [ Homo sapiens (human) ]

    Gene ID: 83439, updated on 10-Dec-2024

    Summary

    Official Symbol
    TCF7L1provided by HGNC
    Official Full Name
    transcription factor 7 like 1provided by HGNC
    Primary source
    HGNC:HGNC:11640
    See related
    Ensembl:ENSG00000152284 MIM:604652; AllianceGenome:HGNC:11640
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    TCF3; TCF-3
    Summary
    This gene encodes a member of the T cell factor/lymphoid enhancer factor family of transcription factors. These transcription factors are activated by beta catenin, mediate the Wnt signaling pathway and are antagonized by the transforming growth factor beta signaling pathway. The encoded protein contains a high mobility group-box DNA binding domain and participates in the regulation of cell cycle genes and cellular senescence. [provided by RefSeq, Nov 2010]
    Expression
    Ubiquitous expression in fat (RPKM 14.2), ovary (RPKM 9.6) and 23 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See TCF7L1 in Genome Data Viewer
    Location:
    2p11.2
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (85133392..85310387)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (85135301..85312378)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (85360515..85537510)

    Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 1964 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:85304907-85305408 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:85305409-85305908 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr2:85346954-85347553 Neighboring gene LSM3 homolog, U6 small nuclear RNA and mRNA degradation associated pseudogene 3 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11694 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:85360550-85361124 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:85361700-85362274 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr2:85362275-85362848 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:85386601-85387191 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:85390033-85390532 Neighboring gene ReSE screen-validated silencer GRCh37_chr2:85408515-85408652 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:85408761-85409408 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:85416914-85417415 Neighboring gene TCF7L1 intronic transcript 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:85440681-85441182 Neighboring gene uncharacterized LOC102724579 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:85442025-85442959 Neighboring gene RNA, U6 small nuclear 674, pseudogene Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:85461879-85462384 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:85464915-85465420 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:85465421-85465924 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:85482618-85483340 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:85483341-85484064 Neighboring gene Sharpr-MPRA regulatory region 427 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:85486956-85487677 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:85489661-85490588 Neighboring gene SNRPE pseudogene 11 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11695 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:85517073-85517573 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:85521502-85522173 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:85533336-85533836 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:85536759-85537642 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:85540508-85541008 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16116 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16117 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16118 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16119 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:85561675-85562174 Neighboring gene trans-golgi network protein 2 Neighboring gene phosphatidylethanolamine binding protein 1 pseudogene 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Process Evidence Code Pubs
    involved_in canonical Wnt signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in chromatin organization NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in regulation of DNA-templated transcription NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in regulation of Wnt signaling pathway NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    part_of beta-catenin-TCF complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in chromatin IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
     
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
     
    located_in nucleus NAS
    Non-traceable Author Statement
    more info
    PubMed 

    General protein information

    Preferred Names
    transcription factor 7-like 1
    Names
    HMG box transcription factor 3
    transcription factor 7-like 1 (T-cell specific, HMG-box)

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_031283.3NP_112573.1  transcription factor 7-like 1

      See identical proteins and their annotated locations for NP_112573.1

      Status: REVIEWED

      Source sequence(s)
      AB031046, AC011236, AC093162, BC058894, BF434361
      Consensus CDS
      CCDS1971.1
      UniProtKB/Swiss-Prot
      Q53R97, Q6PD70, Q9HCS4, Q9NP00
      Related
      ENSP00000282111.3, ENST00000282111.4
      Conserved Domains (2) summary
      cd01388
      Location:345416
      SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...
      pfam08347
      Location:30250
      CTNNB1_binding; N-terminal CTNNB1 binding

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

      Range
      85133392..85310387
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006712109.3XP_006712172.1  transcription factor 7-like 1 isoform X1

      Conserved Domains (2) summary
      cd01388
      Location:346417
      SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...
      pfam08347
      Location:30251
      CTNNB1_binding; N-terminal CTNNB1 binding

    Reference GRCh38.p14 PATCHES

    Genomic

    1. NW_025791763.1 Reference GRCh38.p14 PATCHES

      Range
      59578..236573
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054332904.1XP_054188879.1  transcription factor 7-like 1 isoform X1

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060926.1 Alternate T2T-CHM13v2.0

      Range
      85135301..85312378
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054344107.1XP_054200082.1  transcription factor 7-like 1 isoform X1